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α-1 Antitrypsin Deficiency
Jorge Alberto Carrillo-Bayona, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • α-1 antitrypsin (AAT)
                • AAT deficiency (AATD)
              • Definitions

                • AATD: Genetic disorder characterized by reduced levels of AAT protease inhibitor
                • Emphysema: Abnormal, permanent enlargement of airspaces distal to terminal bronchiole, associated with destruction of their walls
                  • Panlobular emphysema: Pathological subtype of emphysema associated with AATD

              IMAGING

              • General Features

                • Radiographic Findings

                  • CT Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Microscopic Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Treatment

                                  DIAGNOSTIC CHECKLIST

                                  • Consider

                                    Selected References

                                    1. Green CE et al: Lung density associates with survival in alpha 1 antitrypsin deficient patients. Respir Med. 112:81-7, 2016
                                    2. Hatipoğlu U et al: α1-antitrypsin deficiency. Clin Chest Med. 37(3):487-504, 2016
                                    Related Anatomy
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                                    Related Differential Diagnoses
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                                    References
                                    Tables

                                    Tables

                                    KEY FACTS

                                    • Terminology

                                      • Imaging

                                        • Top Differential Diagnoses

                                          • Pathology

                                            • Clinical Issues

                                              • Diagnostic Checklist

                                                TERMINOLOGY

                                                • Abbreviations

                                                  • α-1 antitrypsin (AAT)
                                                  • AAT deficiency (AATD)
                                                • Definitions

                                                  • AATD: Genetic disorder characterized by reduced levels of AAT protease inhibitor
                                                  • Emphysema: Abnormal, permanent enlargement of airspaces distal to terminal bronchiole, associated with destruction of their walls
                                                    • Panlobular emphysema: Pathological subtype of emphysema associated with AATD

                                                IMAGING

                                                • General Features

                                                  • Radiographic Findings

                                                    • CT Findings

                                                      • Imaging Recommendations

                                                        DIFFERENTIAL DIAGNOSIS

                                                          PATHOLOGY

                                                          • General Features

                                                            • Microscopic Features

                                                              CLINICAL ISSUES

                                                              • Presentation

                                                                • Demographics

                                                                  • Treatment

                                                                    DIAGNOSTIC CHECKLIST

                                                                    • Consider

                                                                      Selected References

                                                                      1. Green CE et al: Lung density associates with survival in alpha 1 antitrypsin deficient patients. Respir Med. 112:81-7, 2016
                                                                      2. Hatipoğlu U et al: α1-antitrypsin deficiency. Clin Chest Med. 37(3):487-504, 2016