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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- α-1 antitrypsin (AAT)
- AAT deficiency (AATD)
Definitions
- AATD: Genetic disorder characterized by reduced levels of AAT protease inhibitor
- Emphysema: Abnormal, permanent enlargement of airspaces distal to terminal bronchiole, associated with destruction of their walls
- Panlobular emphysema: Pathological subtype of emphysema associated with AATD
IMAGING
General Features
Radiographic Findings
CT Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
- Green CE et al: Lung density associates with survival in alpha 1 antitrypsin deficient patients. Respir Med. 112:81-7, 2016
- Hatipoğlu U et al: α1-antitrypsin deficiency. Clin Chest Med. 37(3):487-504, 2016
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- α-1 antitrypsin (AAT)
- AAT deficiency (AATD)
Definitions
- AATD: Genetic disorder characterized by reduced levels of AAT protease inhibitor
- Emphysema: Abnormal, permanent enlargement of airspaces distal to terminal bronchiole, associated with destruction of their walls
- Panlobular emphysema: Pathological subtype of emphysema associated with AATD
IMAGING
General Features
Radiographic Findings
CT Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
- Green CE et al: Lung density associates with survival in alpha 1 antitrypsin deficient patients. Respir Med. 112:81-7, 2016
- Hatipoğlu U et al: α1-antitrypsin deficiency. Clin Chest Med. 37(3):487-504, 2016
