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Abdominal Carcinoid Tumors
Jennifer Schroeder, MD; Paige Bennett, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Diagnostic Checklist

          TERMINOLOGY

          • Definitions

            • Carcinoid tumors arise from neural crest cells
              • Normal derivatives from neural crest cell normally express low levels of human somatostatin receptor (SSTR)
              • 5 subtypes of human SSTR (1-5)
              • Carcinoid tumors express varying levels of SSTR depending on level of differentiation
              • World Heath Organization uses neuroendocrine tumor (NET) as synonym
            • Locations
              • Gastrointestinal tract, with most common location being small intestines
              • Lung

          IMAGING

          • Ga-68 Dota-Peptides PET/CT Findings

            • F-18 FDG PET/CT Findings

              • In-111 Pentetreotide Findings

                • CECT Findings

                  • MR Findings

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • Staging, Grading, & Classification

                        • Microscopic Features

                          CLINICAL ISSUES

                          • Presentation

                            • Treatment

                              DIAGNOSTIC CHECKLIST

                              • Consider

                                Selected References

                                1. Degnan AJ et al: Pediatric neuroendocrine carcinoid tumors: review of diagnostic imaging findings and recent advances. AJR Am J Roentgenol. 208(4):868-877, 2017
                                2. Deppen SA et al: Safety and efficacy of 68Ga-DOTATATE PET/CT for diagnosis, staging, and treatment management of neuroendocrine tumors. J Nucl Med. 57(5):708-14, 2016
                                3. Sadowski SM et al: Prospective study of 68Ga-DOTATATE positron emission tomography/computed tomography for detecting gastro-entero-pancreatic neuroendocrine tumors and unknown primary sites. J Clin Oncol. 34(6):588-96, 2016
                                4. Hofman MS et al: Somatostatin receptor imaging with 68Ga DOTATATE PET/CT: clinical utility, normal patterns, pearls, and pitfalls in interpretation. Radiographics. 35(2):500-16, 2015
                                Related Anatomy
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                                Related Differential Diagnoses
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                                References
                                Tables

                                Tables

                                KEY FACTS

                                • Terminology

                                  • Imaging

                                    • Top Differential Diagnoses

                                      • Diagnostic Checklist

                                        TERMINOLOGY

                                        • Definitions

                                          • Carcinoid tumors arise from neural crest cells
                                            • Normal derivatives from neural crest cell normally express low levels of human somatostatin receptor (SSTR)
                                            • 5 subtypes of human SSTR (1-5)
                                            • Carcinoid tumors express varying levels of SSTR depending on level of differentiation
                                            • World Heath Organization uses neuroendocrine tumor (NET) as synonym
                                          • Locations
                                            • Gastrointestinal tract, with most common location being small intestines
                                            • Lung

                                        IMAGING

                                        • Ga-68 Dota-Peptides PET/CT Findings

                                          • F-18 FDG PET/CT Findings

                                            • In-111 Pentetreotide Findings

                                              • CECT Findings

                                                • MR Findings

                                                  DIFFERENTIAL DIAGNOSIS

                                                    PATHOLOGY

                                                    • Staging, Grading, & Classification

                                                      • Microscopic Features

                                                        CLINICAL ISSUES

                                                        • Presentation

                                                          • Treatment

                                                            DIAGNOSTIC CHECKLIST

                                                            • Consider

                                                              Selected References

                                                              1. Degnan AJ et al: Pediatric neuroendocrine carcinoid tumors: review of diagnostic imaging findings and recent advances. AJR Am J Roentgenol. 208(4):868-877, 2017
                                                              2. Deppen SA et al: Safety and efficacy of 68Ga-DOTATATE PET/CT for diagnosis, staging, and treatment management of neuroendocrine tumors. J Nucl Med. 57(5):708-14, 2016
                                                              3. Sadowski SM et al: Prospective study of 68Ga-DOTATATE positron emission tomography/computed tomography for detecting gastro-entero-pancreatic neuroendocrine tumors and unknown primary sites. J Clin Oncol. 34(6):588-96, 2016
                                                              4. Hofman MS et al: Somatostatin receptor imaging with 68Ga DOTATATE PET/CT: clinical utility, normal patterns, pearls, and pitfalls in interpretation. Radiographics. 35(2):500-16, 2015