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Acroosteolysis
Donna G. Blankenbaker, MD, FACR; B. J. Manaster, MD, PhD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Diagnostic Checklist

          TERMINOLOGY

          • Definitions

            • Destruction of bone = osteolysis
            • Acral = distal aspect of digits
            • Group of processes with shortening of distal phalanges as common feature

          IMAGING

          • General Features

            • Radiographic Findings

              • Ultrasonographic Findings

                DIFFERENTIAL DIAGNOSIS

                  PATHOLOGY

                  • General Features

                    CLINICAL ISSUES

                    • Treatment

                      DIAGNOSTIC CHECKLIST

                      • Image Interpretation Pearls

                        Selected References

                        1. Colquhoun M et al: Band acro-osteolysis in systemic sclerosis. Rheumatology (Oxford). 2;60(10):4945, 2021
                        2. Cortés-Martín J et al: Hajdu-Cheney syndrome: a systematic review of the literature. Int J Environ Res Public Health. 17(17), 2020
                        3. Sandler RD et al: Musculoskeletal hand involvement in systemic sclerosis. Semin Arthritis Rheum. 50(2):329-34, 2020
                        4. Botou A et al: Acro-osteolysis. Clin Rheumatol. 36(1):9-14, 2017
                        5. Canalis E et al: Hajdu-Cheney syndrome: a review. Orphanet J Rare Dis. 9(1):200, 2014
                        6. Turan S: Current research on pycnodysostosis. Intractable Rare Dis Res. 3(3):91-3, 2014
                        7. Freire V et al: Hand and wrist involvement in systemic sclerosis: US features. Radiology. 269(3):824-30, 2013
                        8. Baer AN et al: Acroosteolysis in diabetes mellitus. J Rheumatol. 39(12):2364-5, 2012
                        9. Bocci EB et al: Acro-osteolysis of the big toe in a patient with psoriatic arthritis. J Rheumatol. 36(9):2044, 2009
                        10. Alves Pereira D et al: Pycnodysostosis. A report of 3 clinical cases. Med Oral Patol Oral Cir Bucal. 13(10):E633-5, 2008
                        11. Braun-Moscovici Y et al: Vitamin D, parathyroid hormone, and acroosteolysis in systemic sclerosis. J Rheumatol. 35(11):2201-5, 2008
                        12. Rozenbaum M et al: Catastrophic acro-osteolysis of hands in systemic sclerosis. J Clin Rheumatol. 13(3):169-70, 2007
                        13. Avouac J et al: Radiological hand involvement in systemic sclerosis. Ann Rheum Dis. 65(8):1088-92, 2006
                        14. Hu J et al: Congenital insensitivity to pain with anhidrosis and progressing acro-osteolysis: a case report with 7-year follow-up. Chin Med J (Engl). 119(24):2134-7, 2006
                        15. Marik I et al: Hajdu-Cheney syndrome: report of a family and a short literature review. Australas Radiol. 50(6):534-8, 2006
                        16. Brennan AM et al: Hajdu--Cheney syndrome: evolution of phenotype and clinical problems. Am J Med Genet. 100(4):292-310, 2001
                        Related Anatomy
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                        Related Differential Diagnoses
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                        References
                        Tables

                        Tables

                        KEY FACTS

                        • Terminology

                          • Imaging

                            • Top Differential Diagnoses

                              • Diagnostic Checklist

                                TERMINOLOGY

                                • Definitions

                                  • Destruction of bone = osteolysis
                                  • Acral = distal aspect of digits
                                  • Group of processes with shortening of distal phalanges as common feature

                                IMAGING

                                • General Features

                                  • Radiographic Findings

                                    • Ultrasonographic Findings

                                      DIFFERENTIAL DIAGNOSIS

                                        PATHOLOGY

                                        • General Features

                                          CLINICAL ISSUES

                                          • Treatment

                                            DIAGNOSTIC CHECKLIST

                                            • Image Interpretation Pearls

                                              Selected References

                                              1. Colquhoun M et al: Band acro-osteolysis in systemic sclerosis. Rheumatology (Oxford). 2;60(10):4945, 2021
                                              2. Cortés-Martín J et al: Hajdu-Cheney syndrome: a systematic review of the literature. Int J Environ Res Public Health. 17(17), 2020
                                              3. Sandler RD et al: Musculoskeletal hand involvement in systemic sclerosis. Semin Arthritis Rheum. 50(2):329-34, 2020
                                              4. Botou A et al: Acro-osteolysis. Clin Rheumatol. 36(1):9-14, 2017
                                              5. Canalis E et al: Hajdu-Cheney syndrome: a review. Orphanet J Rare Dis. 9(1):200, 2014
                                              6. Turan S: Current research on pycnodysostosis. Intractable Rare Dis Res. 3(3):91-3, 2014
                                              7. Freire V et al: Hand and wrist involvement in systemic sclerosis: US features. Radiology. 269(3):824-30, 2013
                                              8. Baer AN et al: Acroosteolysis in diabetes mellitus. J Rheumatol. 39(12):2364-5, 2012
                                              9. Bocci EB et al: Acro-osteolysis of the big toe in a patient with psoriatic arthritis. J Rheumatol. 36(9):2044, 2009
                                              10. Alves Pereira D et al: Pycnodysostosis. A report of 3 clinical cases. Med Oral Patol Oral Cir Bucal. 13(10):E633-5, 2008
                                              11. Braun-Moscovici Y et al: Vitamin D, parathyroid hormone, and acroosteolysis in systemic sclerosis. J Rheumatol. 35(11):2201-5, 2008
                                              12. Rozenbaum M et al: Catastrophic acro-osteolysis of hands in systemic sclerosis. J Clin Rheumatol. 13(3):169-70, 2007
                                              13. Avouac J et al: Radiological hand involvement in systemic sclerosis. Ann Rheum Dis. 65(8):1088-92, 2006
                                              14. Hu J et al: Congenital insensitivity to pain with anhidrosis and progressing acro-osteolysis: a case report with 7-year follow-up. Chin Med J (Engl). 119(24):2134-7, 2006
                                              15. Marik I et al: Hajdu-Cheney syndrome: report of a family and a short literature review. Australas Radiol. 50(6):534-8, 2006
                                              16. Brennan AM et al: Hajdu--Cheney syndrome: evolution of phenotype and clinical problems. Am J Med Genet. 100(4):292-310, 2001