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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Synonyms
- TransIent perivascular inflammation of carotid artery (TIPIC) syndrome
- Idiopathic or sclerosing (inflammatory) pseudotumor
- Idiopathic carotiditis
- Fay syndrome
Definitions
- Self-limited inflammatory disorder of carotid artery causing carotid wall thickening & pain
- Proposed TIPIC criteria
- Acute pain overlying carotid artery ± radiation to head
- Eccentric perivascular infiltration on imaging
- Exclude other vascular/nonvascular diagnosis by imaging
- Improvement within 14 days
- Spontaneously or with antiinflammatory treatment
- Minor criterion of self-limited intimal soft plaque suggested
- Prior International Headache Society Classification Committee (IHSCC) criteria for diagnosis: Self-limited illness with ≥ 1 of following: Tenderness to palpation, swelling, increased pulsations over carotid
- Not currently recognized by International Classification of Headache Disorders, 3rd edition in 2018
IMAGING
General Features
Imaging Recommendations
Ultrasonographic Findings
MR Findings
CT Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Mumoli N et al: Transient perivascular inflammation of the carotid artery (TIPIC) syndrome in a patient with COVID-19. Int J Infect Dis. 108:126-8, 2021
- Scoppettuolo P et al: Multimodal imaging for a TIPIC syndrome case. Acta Neurol Belg. ePub, 2021
- Rafailidis V et al: Role of multi-parametric ultrasound in transient perivascular inflammation of the carotid artery syndrome. Ultrasound. 27(2):77-84, 2019
- Ulus S et al: Imaging spectrum of TIPIC syndrome: validation of a new entity with vessel wall imaging. Clin Neuroradiol. 30(1):145-57, 2018
- Abrahamy M et al: Ultrasound for the diagnosis of carotidynia. J Ultrasound Med. 36(12):2605-9, 2017
- Lecler A et al: TIPIC syndrome: beyond the myth of carotidynia, a new distinct unclassified entity. AJNR Am J Neuroradiol. 38(7):1391-8, 2017
- Behar T et al: Comparative evolution of carotidynia on ultrasound and magnetic resonance imaging. J Mal Vasc. 40(6):395-8, 2015
- Young JY et al: CT findings in a patient with bilateral metachronous carotidynia. Clin Imaging. 39(2):305-7, 2015
- Berzaczy D et al: Imaging of a case of benign carotidynia with ultrasound, MRI and PET-CT. Wien Klin Wochenschr. 125(21-22):719-20, 2013
- Pina S et al: Burkitt lymphoma as a cause of carotidynia: imaging features. A case report. Neuroradiol J. 26(1):18-20, 2013
- Azar L et al: Perivascular carotid inflammation: an unusual case of carotidynia. Rheumatol Int. 32(2):457-9, 2012
- Comacchio F et al: Carotidynia: new aspects of a controversial entity. Acta Otorhinolaryngol Ital. 32(4):266-9, 2012
- Schaumberg J et al: Carotidynia: magnetic resonance imaging and ultrasonographic imaging of a self-limiting disease. Clin Neuroradiol. 21(2):91-4, 2011
- da Rocha AJ et al: Imaging contribution for the diagnosis of carotidynia. J Headache Pain. 10(2):125-7, 2009
- Park JK et al: CT imaging features of carotidynia: a case report. J Neuroimaging. 19(1):84-5, 2009
- Amaravadi RR et al: [18F.] Fluorodeoxyglucose positron-emission tomography-CT imaging of carotidynia. AJNR Am J Neuroradiol. 29(6):1197-9, 2008
- Taniguchi Y et al: Is carotidynia syndrome a subset of vasculitis? J Rheumatol. 35(9):1901-2, 2008
- Kosaka N et al: Imaging by multiple modalities of patients with a carotidynia syndrome. Eur Radiol. 17(9):2430-3, 2007
- Tardy J et al: Carotidynia: a new case for an old controversy. Eur J Neurol. 14(6):704-5, 2007
- Second Headache Classification Subcommittee of the International Headache Society. Classification and diagnosis criteria for headache disorders, cranial neuralgias and facial pain. Cephalalgia. 24 (Suppl):70-1, 2004
- Upton PD et al: Histologic confirmation of carotidynia. Otolaryngol Head Neck Surg. 129(4):443-4, 2003
- Burton BS et al: MR imaging of patients with carotidynia. AJNR Am J Neuroradiol. 21(4):766-9, 2000
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Synonyms
- TransIent perivascular inflammation of carotid artery (TIPIC) syndrome
- Idiopathic or sclerosing (inflammatory) pseudotumor
- Idiopathic carotiditis
- Fay syndrome
Definitions
- Self-limited inflammatory disorder of carotid artery causing carotid wall thickening & pain
- Proposed TIPIC criteria
- Acute pain overlying carotid artery ± radiation to head
- Eccentric perivascular infiltration on imaging
- Exclude other vascular/nonvascular diagnosis by imaging
- Improvement within 14 days
- Spontaneously or with antiinflammatory treatment
- Minor criterion of self-limited intimal soft plaque suggested
- Prior International Headache Society Classification Committee (IHSCC) criteria for diagnosis: Self-limited illness with ≥ 1 of following: Tenderness to palpation, swelling, increased pulsations over carotid
- Not currently recognized by International Classification of Headache Disorders, 3rd edition in 2018
IMAGING
General Features
Imaging Recommendations
Ultrasonographic Findings
MR Findings
CT Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Mumoli N et al: Transient perivascular inflammation of the carotid artery (TIPIC) syndrome in a patient with COVID-19. Int J Infect Dis. 108:126-8, 2021
- Scoppettuolo P et al: Multimodal imaging for a TIPIC syndrome case. Acta Neurol Belg. ePub, 2021
- Rafailidis V et al: Role of multi-parametric ultrasound in transient perivascular inflammation of the carotid artery syndrome. Ultrasound. 27(2):77-84, 2019
- Ulus S et al: Imaging spectrum of TIPIC syndrome: validation of a new entity with vessel wall imaging. Clin Neuroradiol. 30(1):145-57, 2018
- Abrahamy M et al: Ultrasound for the diagnosis of carotidynia. J Ultrasound Med. 36(12):2605-9, 2017
- Lecler A et al: TIPIC syndrome: beyond the myth of carotidynia, a new distinct unclassified entity. AJNR Am J Neuroradiol. 38(7):1391-8, 2017
- Behar T et al: Comparative evolution of carotidynia on ultrasound and magnetic resonance imaging. J Mal Vasc. 40(6):395-8, 2015
- Young JY et al: CT findings in a patient with bilateral metachronous carotidynia. Clin Imaging. 39(2):305-7, 2015
- Berzaczy D et al: Imaging of a case of benign carotidynia with ultrasound, MRI and PET-CT. Wien Klin Wochenschr. 125(21-22):719-20, 2013
- Pina S et al: Burkitt lymphoma as a cause of carotidynia: imaging features. A case report. Neuroradiol J. 26(1):18-20, 2013
- Azar L et al: Perivascular carotid inflammation: an unusual case of carotidynia. Rheumatol Int. 32(2):457-9, 2012
- Comacchio F et al: Carotidynia: new aspects of a controversial entity. Acta Otorhinolaryngol Ital. 32(4):266-9, 2012
- Schaumberg J et al: Carotidynia: magnetic resonance imaging and ultrasonographic imaging of a self-limiting disease. Clin Neuroradiol. 21(2):91-4, 2011
- da Rocha AJ et al: Imaging contribution for the diagnosis of carotidynia. J Headache Pain. 10(2):125-7, 2009
- Park JK et al: CT imaging features of carotidynia: a case report. J Neuroimaging. 19(1):84-5, 2009
- Amaravadi RR et al: [18F.] Fluorodeoxyglucose positron-emission tomography-CT imaging of carotidynia. AJNR Am J Neuroradiol. 29(6):1197-9, 2008
- Taniguchi Y et al: Is carotidynia syndrome a subset of vasculitis? J Rheumatol. 35(9):1901-2, 2008
- Kosaka N et al: Imaging by multiple modalities of patients with a carotidynia syndrome. Eur Radiol. 17(9):2430-3, 2007
- Tardy J et al: Carotidynia: a new case for an old controversy. Eur J Neurol. 14(6):704-5, 2007
- Second Headache Classification Subcommittee of the International Headache Society. Classification and diagnosis criteria for headache disorders, cranial neuralgias and facial pain. Cephalalgia. 24 (Suppl):70-1, 2004
- Upton PD et al: Histologic confirmation of carotidynia. Otolaryngol Head Neck Surg. 129(4):443-4, 2003
- Burton BS et al: MR imaging of patients with carotidynia. AJNR Am J Neuroradiol. 21(4):766-9, 2000
