Acute pain overlying carotid artery ± radiation to head
Eccentric perivascular infiltration on imaging
Exclude other vascular/nonvascular diagnosis by imaging
Improvement within 14 days
Spontaneously or with antiinflammatory treatment
Minor criterion of self-limited intimal soft plaque suggested
Prior International Headache Society Classification Committee (IHSCC) criteria for diagnosis: Self-limited illness with ≥ 1 of following: Tenderness to palpation, swelling, increased pulsations over carotid
Not currently recognized by International Classification of Headache Disorders, 3rd edition in 2018
IMAGING
General Features
Imaging Recommendations
Ultrasonographic Findings
MR Findings
CT Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Mumoli N et al: Transient perivascular inflammation of the carotid artery (TIPIC) syndrome in a patient with COVID-19. Int J Infect Dis. 108:126-8, 2021
Scoppettuolo P et al: Multimodal imaging for a TIPIC syndrome case. Acta Neurol Belg. ePub, 2021
Rafailidis V et al: Role of multi-parametric ultrasound in transient perivascular inflammation of the carotid artery syndrome. Ultrasound. 27(2):77-84, 2019
Ulus S et al: Imaging spectrum of TIPIC syndrome: validation of a new entity with vessel wall imaging. Clin Neuroradiol. 30(1):145-57, 2018
Abrahamy M et al: Ultrasound for the diagnosis of carotidynia. J Ultrasound Med. 36(12):2605-9, 2017
Lecler A et al: TIPIC syndrome: beyond the myth of carotidynia, a new distinct unclassified entity. AJNR Am J Neuroradiol. 38(7):1391-8, 2017
Behar T et al: Comparative evolution of carotidynia on ultrasound and magnetic resonance imaging. J Mal Vasc. 40(6):395-8, 2015
Young JY et al: CT findings in a patient with bilateral metachronous carotidynia. Clin Imaging. 39(2):305-7, 2015
Berzaczy D et al: Imaging of a case of benign carotidynia with ultrasound, MRI and PET-CT. Wien Klin Wochenschr. 125(21-22):719-20, 2013
Pina S et al: Burkitt lymphoma as a cause of carotidynia: imaging features. A case report. Neuroradiol J. 26(1):18-20, 2013
Azar L et al: Perivascular carotid inflammation: an unusual case of carotidynia. Rheumatol Int. 32(2):457-9, 2012
Comacchio F et al: Carotidynia: new aspects of a controversial entity. Acta Otorhinolaryngol Ital. 32(4):266-9, 2012
Schaumberg J et al: Carotidynia: magnetic resonance imaging and ultrasonographic imaging of a self-limiting disease. Clin Neuroradiol. 21(2):91-4, 2011
da Rocha AJ et al: Imaging contribution for the diagnosis of carotidynia. J Headache Pain. 10(2):125-7, 2009
Park JK et al: CT imaging features of carotidynia: a case report. J Neuroimaging. 19(1):84-5, 2009
Amaravadi RR et al: [18F.] Fluorodeoxyglucose positron-emission tomography-CT imaging of carotidynia. AJNR Am J Neuroradiol. 29(6):1197-9, 2008
Taniguchi Y et al: Is carotidynia syndrome a subset of vasculitis? J Rheumatol. 35(9):1901-2, 2008
Kosaka N et al: Imaging by multiple modalities of patients with a carotidynia syndrome. Eur Radiol. 17(9):2430-3, 2007
Tardy J et al: Carotidynia: a new case for an old controversy. Eur J Neurol. 14(6):704-5, 2007
Second Headache Classification Subcommittee of the International Headache Society. Classification and diagnosis criteria for headache disorders, cranial neuralgias and facial pain. Cephalalgia. 24 (Suppl):70-1, 2004
Upton PD et al: Histologic confirmation of carotidynia. Otolaryngol Head Neck Surg. 129(4):443-4, 2003
Burton BS et al: MR imaging of patients with carotidynia. AJNR Am J Neuroradiol. 21(4):766-9, 2000
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Synonyms
TransIent perivascular inflammation of carotid artery (TIPIC) syndrome
Idiopathic or sclerosing (inflammatory) pseudotumor
Acute pain overlying carotid artery ± radiation to head
Eccentric perivascular infiltration on imaging
Exclude other vascular/nonvascular diagnosis by imaging
Improvement within 14 days
Spontaneously or with antiinflammatory treatment
Minor criterion of self-limited intimal soft plaque suggested
Prior International Headache Society Classification Committee (IHSCC) criteria for diagnosis: Self-limited illness with ≥ 1 of following: Tenderness to palpation, swelling, increased pulsations over carotid
Not currently recognized by International Classification of Headache Disorders, 3rd edition in 2018
IMAGING
General Features
Imaging Recommendations
Ultrasonographic Findings
MR Findings
CT Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Mumoli N et al: Transient perivascular inflammation of the carotid artery (TIPIC) syndrome in a patient with COVID-19. Int J Infect Dis. 108:126-8, 2021
Scoppettuolo P et al: Multimodal imaging for a TIPIC syndrome case. Acta Neurol Belg. ePub, 2021
Rafailidis V et al: Role of multi-parametric ultrasound in transient perivascular inflammation of the carotid artery syndrome. Ultrasound. 27(2):77-84, 2019
Ulus S et al: Imaging spectrum of TIPIC syndrome: validation of a new entity with vessel wall imaging. Clin Neuroradiol. 30(1):145-57, 2018
Abrahamy M et al: Ultrasound for the diagnosis of carotidynia. J Ultrasound Med. 36(12):2605-9, 2017
Lecler A et al: TIPIC syndrome: beyond the myth of carotidynia, a new distinct unclassified entity. AJNR Am J Neuroradiol. 38(7):1391-8, 2017
Behar T et al: Comparative evolution of carotidynia on ultrasound and magnetic resonance imaging. J Mal Vasc. 40(6):395-8, 2015
Young JY et al: CT findings in a patient with bilateral metachronous carotidynia. Clin Imaging. 39(2):305-7, 2015
Berzaczy D et al: Imaging of a case of benign carotidynia with ultrasound, MRI and PET-CT. Wien Klin Wochenschr. 125(21-22):719-20, 2013
Pina S et al: Burkitt lymphoma as a cause of carotidynia: imaging features. A case report. Neuroradiol J. 26(1):18-20, 2013
Azar L et al: Perivascular carotid inflammation: an unusual case of carotidynia. Rheumatol Int. 32(2):457-9, 2012
Comacchio F et al: Carotidynia: new aspects of a controversial entity. Acta Otorhinolaryngol Ital. 32(4):266-9, 2012
Schaumberg J et al: Carotidynia: magnetic resonance imaging and ultrasonographic imaging of a self-limiting disease. Clin Neuroradiol. 21(2):91-4, 2011
da Rocha AJ et al: Imaging contribution for the diagnosis of carotidynia. J Headache Pain. 10(2):125-7, 2009
Park JK et al: CT imaging features of carotidynia: a case report. J Neuroimaging. 19(1):84-5, 2009
Amaravadi RR et al: [18F.] Fluorodeoxyglucose positron-emission tomography-CT imaging of carotidynia. AJNR Am J Neuroradiol. 29(6):1197-9, 2008
Taniguchi Y et al: Is carotidynia syndrome a subset of vasculitis? J Rheumatol. 35(9):1901-2, 2008
Kosaka N et al: Imaging by multiple modalities of patients with a carotidynia syndrome. Eur Radiol. 17(9):2430-3, 2007
Tardy J et al: Carotidynia: a new case for an old controversy. Eur J Neurol. 14(6):704-5, 2007
Second Headache Classification Subcommittee of the International Headache Society. Classification and diagnosis criteria for headache disorders, cranial neuralgias and facial pain. Cephalalgia. 24 (Suppl):70-1, 2004
Upton PD et al: Histologic confirmation of carotidynia. Otolaryngol Head Neck Surg. 129(4):443-4, 2003
Burton BS et al: MR imaging of patients with carotidynia. AJNR Am J Neuroradiol. 21(4):766-9, 2000
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