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Adamantinoma
Behrang Amini, MD, PhDB. J. Manaster, MD, PhD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Clinical Issues

        TERMINOLOGY

        • Synonyms

          • Adamantinoma of long bones, extragnathic adamantinoma, differentiated adamantinoma, juvenile intracortical adamantinoma
        • Definitions

          • Low-grade, locally aggressive, malignant lesion usually arising in tibial cortex

        IMAGING

        • General Features

          • Radiographic Findings

            • CT Findings

              • MR Findings

                • Imaging Recommendations

                  • Image-Guided Biopsy

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Staging, Grading, & Classification

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        • Reporting Tips

                                          Selected References

                                          1. Nielsen GP et al: Adamantinoma of long bones. In Fletcher CDM et al: WHO Classification of Tumours: Tumours of Soft Tissue and Bone. IARC Press. 463-6, 2020
                                          2. Rekhi B et al: Clinicopathologic features of two rare cases of dedifferentiated adamantinomas, including diagnostic implications. Int J Surg Pathol. 27(2):193-202, 2019
                                          3. Bethapudi S et al: Imaging in osteofibrous dysplasia, osteofibrous dysplasia-like adamantinoma, and classic adamantinoma. Clin Radiol. 69(2):200-8, 2014
                                          4. Giannoulis DK et al: Multiple recurrences and late metastasis of adamantinoma in the tibia: a case report. J Orthop Surg (Hong Kong). 22(3):420-2, 2014
                                          5. Ramanoudjame M et al: Is there a link between osteofibrous dysplasia and adamantinoma? Orthop Traumatol Surg Res. 97(8):877-80, 2011
                                          6. Most MJ et al: Osteofibrous dysplasia and adamantinoma. J Am Acad Orthop Surg. 18(6):358-66, 2010
                                          7. Szendroi M et al: Adamantinoma of long bones: a long-term follow-up study of 11 cases. Pathol Oncol Res. 15(2):209-16, 2009
                                          8. Camp MD et al: Best cases from the AFIP: adamantinoma of the tibia and fibula with cytogenetic analysis. Radiographics. 28(4):1215-20, 2008
                                          9. Gleason BC et al: Osteofibrous dysplasia and adamantinoma in children and adolescents: a clinicopathologic reappraisal. Am J Surg Pathol. 32(3):363-76, 2008
                                          10. Khanna M et al: Osteofibrous dysplasia, osteofibrous dysplasia-like adamantinoma and adamantinoma: correlation of radiological imaging features with surgical histology and assessment of the use of radiology in contributing to needle biopsy diagnosis. Skeletal Radiol. 37(12):1077-84, 2008
                                          11. Papagelopoulos PJ et al: Clinicopathological features, diagnosis, and treatment of adamantinoma of the long bones. Orthopedics. 30(3):211-5; quiz 216-7, 2007
                                          12. Lee RS et al: Osteofibrous dysplasia of the tibia. Is there a need for a radical surgical approach? J Bone Joint Surg Br. 88(5):658-64, 2006
                                          13. Van Rijn R et al: Adamantinoma in childhood: report of six cases and review of the literature. Pediatr Radiol. 36(10):1068-74, 2006
                                          14. Van der Woude HJ et al: MRI of adamantinoma of long bones in correlation with histopathology. AJR Am J Roentgenol. 183(6):1737-44, 2004
                                          15. Kahn LB: Adamantinoma, osteofibrous dysplasia and differentiated adamantinoma. Skeletal Radiol. 32(5):245-58, 2003
                                          16. Springfield DS et al: Relationship between osteofibrous dysplasia and adamantinoma. Clin Orthop Relat Res. (309):234-44, 1994
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Clinical Issues

                                                TERMINOLOGY

                                                • Synonyms

                                                  • Adamantinoma of long bones, extragnathic adamantinoma, differentiated adamantinoma, juvenile intracortical adamantinoma
                                                • Definitions

                                                  • Low-grade, locally aggressive, malignant lesion usually arising in tibial cortex

                                                IMAGING

                                                • General Features

                                                  • Radiographic Findings

                                                    • CT Findings

                                                      • MR Findings

                                                        • Imaging Recommendations

                                                          • Image-Guided Biopsy

                                                            DIFFERENTIAL DIAGNOSIS

                                                              PATHOLOGY

                                                              • General Features

                                                                • Staging, Grading, & Classification

                                                                  • Gross Pathologic & Surgical Features

                                                                    • Microscopic Features

                                                                      CLINICAL ISSUES

                                                                      • Presentation

                                                                        • Demographics

                                                                          • Natural History & Prognosis

                                                                            • Treatment

                                                                              DIAGNOSTIC CHECKLIST

                                                                              • Consider

                                                                                • Reporting Tips

                                                                                  Selected References

                                                                                  1. Nielsen GP et al: Adamantinoma of long bones. In Fletcher CDM et al: WHO Classification of Tumours: Tumours of Soft Tissue and Bone. IARC Press. 463-6, 2020
                                                                                  2. Rekhi B et al: Clinicopathologic features of two rare cases of dedifferentiated adamantinomas, including diagnostic implications. Int J Surg Pathol. 27(2):193-202, 2019
                                                                                  3. Bethapudi S et al: Imaging in osteofibrous dysplasia, osteofibrous dysplasia-like adamantinoma, and classic adamantinoma. Clin Radiol. 69(2):200-8, 2014
                                                                                  4. Giannoulis DK et al: Multiple recurrences and late metastasis of adamantinoma in the tibia: a case report. J Orthop Surg (Hong Kong). 22(3):420-2, 2014
                                                                                  5. Ramanoudjame M et al: Is there a link between osteofibrous dysplasia and adamantinoma? Orthop Traumatol Surg Res. 97(8):877-80, 2011
                                                                                  6. Most MJ et al: Osteofibrous dysplasia and adamantinoma. J Am Acad Orthop Surg. 18(6):358-66, 2010
                                                                                  7. Szendroi M et al: Adamantinoma of long bones: a long-term follow-up study of 11 cases. Pathol Oncol Res. 15(2):209-16, 2009
                                                                                  8. Camp MD et al: Best cases from the AFIP: adamantinoma of the tibia and fibula with cytogenetic analysis. Radiographics. 28(4):1215-20, 2008
                                                                                  9. Gleason BC et al: Osteofibrous dysplasia and adamantinoma in children and adolescents: a clinicopathologic reappraisal. Am J Surg Pathol. 32(3):363-76, 2008
                                                                                  10. Khanna M et al: Osteofibrous dysplasia, osteofibrous dysplasia-like adamantinoma and adamantinoma: correlation of radiological imaging features with surgical histology and assessment of the use of radiology in contributing to needle biopsy diagnosis. Skeletal Radiol. 37(12):1077-84, 2008
                                                                                  11. Papagelopoulos PJ et al: Clinicopathological features, diagnosis, and treatment of adamantinoma of the long bones. Orthopedics. 30(3):211-5; quiz 216-7, 2007
                                                                                  12. Lee RS et al: Osteofibrous dysplasia of the tibia. Is there a need for a radical surgical approach? J Bone Joint Surg Br. 88(5):658-64, 2006
                                                                                  13. Van Rijn R et al: Adamantinoma in childhood: report of six cases and review of the literature. Pediatr Radiol. 36(10):1068-74, 2006
                                                                                  14. Van der Woude HJ et al: MRI of adamantinoma of long bones in correlation with histopathology. AJR Am J Roentgenol. 183(6):1737-44, 2004
                                                                                  15. Kahn LB: Adamantinoma, osteofibrous dysplasia and differentiated adamantinoma. Skeletal Radiol. 32(5):245-58, 2003
                                                                                  16. Springfield DS et al: Relationship between osteofibrous dysplasia and adamantinoma. Clin Orthop Relat Res. (309):234-44, 1994