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Adenofibroma and Cystadenofibroma
Akram M. Shaaban, MBBCh; Ilse Castro-Aragon, MD; Sandra J. Allison, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          TERMINOLOGY

          • Abbreviations

            • Adenofibroma (AF)
            • Cystadenofibroma (CAF)
          • Definitions

            • Subtype of epithelial ovarian neoplasms in which fibrous stroma is a dominant component in addition to epithelial elements
            • Termed CAF or AF depending on relative amount of cystic and solid fibrous tissue components

          IMAGING

          • General Features

            • CT Findings

              • MR Findings

                • Ultrasonographic Findings

                  • Imaging Recommendations

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • Gross Pathologic & Surgical Features

                        • Microscopic Features

                          CLINICAL ISSUES

                          • Presentation

                            • Demographics

                              • Natural History & Prognosis

                                • Treatment

                                  DIAGNOSTIC CHECKLIST

                                  • Image Interpretation Pearls

                                    Selected References

                                    1. Takeuchi M et al: Ovarian adenofibromas and cystadenofibromas: magnetic resonance imaging findings including diffusion-weighted imaging. Acta Radiol. 54(2):231-6, 2013
                                    2. Tang YZ et al: The MRI features of histologically proven ovarian cystadenofibromas-an assessment of the morphological and enhancement patterns. Eur Radiol. 23(1):48-56, 2013
                                    3. Khashper A et al: T2-hypointense adnexal lesions: an imaging algorithm. Radiographics. 32(4):1047-64, 2012
                                    4. Li W et al: Diffusion-weighted MRI: a useful technique to discriminate benign versus malignant ovarian surface epithelial tumors with solid and cystic components. Abdom Imaging. 37(5):897-903, 2012
                                    5. Takeuchi M et al: Diffusion-weighted magnetic resonance imaging of ovarian tumors: differentiation of benign and malignant solid components of ovarian masses. J Comput Assist Tomogr. 34(2):173-6, 2010
                                    6. Fujii S et al: Diagnostic accuracy of diffusion-weighted imaging in differentiating benign from malignant ovarian lesions. J Magn Reson Imaging. 28(5):1149-56, 2008
                                    7. Stanwell P et al: Evaluation of ovarian tumors by proton magnetic resonance spectroscopy at three Tesla. Invest Radiol. 43(10):745-51, 2008
                                    8. Jung DC et al: MR imaging findings of ovarian cystadenofibroma and cystadenocarcinofibroma: clues for the differential diagnosis. Korean J Radiol. 7(3):199-204, 2006
                                    9. Cho SM et al: CT and MRI findings of cystadenofibromas of the ovary. Eur Radiol. 14(5):798-804, 2004
                                    10. Kim KA et al: Benign ovarian tumors with solid and cystic components that mimic malignancy. AJR Am J Roentgenol. 182(5):1259-65, 2004
                                    11. Takeuchi M et al: Ovarian cystadenofibromas: characteristic magnetic resonance findings with pathologic correlation. J Comput Assist Tomogr. 27(6):871-3, 2003
                                    12. Jung SE et al: CT and MR imaging of ovarian tumors with emphasis on differential diagnosis. Radiographics. 22(6):1305-25, 2002
                                    13. Alcazar JL et al: Sonographic features of ovarian cystadenofibromas: spectrum of findings. J Ultrasound Med. 20(8):915-9, 2001
                                    14. Fatum M et al: Papillary serous cystadenofibroma of the ovary--is it really so rare? Int J Gynaecol Obstet. 75(1):85-6, 2001
                                    15. Outwater EK et al: Ovarian fibromas and cystadenofibromas: MRI features of the fibrous component. J Magn Reson Imaging. 7(3):465-71, 1997
                                    Related Anatomy
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                                    Related Differential Diagnoses
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                                    References
                                    Tables

                                    Tables

                                    KEY FACTS

                                    • Terminology

                                      • Imaging

                                        • Top Differential Diagnoses

                                          • Clinical Issues

                                            TERMINOLOGY

                                            • Abbreviations

                                              • Adenofibroma (AF)
                                              • Cystadenofibroma (CAF)
                                            • Definitions

                                              • Subtype of epithelial ovarian neoplasms in which fibrous stroma is a dominant component in addition to epithelial elements
                                              • Termed CAF or AF depending on relative amount of cystic and solid fibrous tissue components

                                            IMAGING

                                            • General Features

                                              • CT Findings

                                                • MR Findings

                                                  • Ultrasonographic Findings

                                                    • Imaging Recommendations

                                                      DIFFERENTIAL DIAGNOSIS

                                                        PATHOLOGY

                                                        • Gross Pathologic & Surgical Features

                                                          • Microscopic Features

                                                            CLINICAL ISSUES

                                                            • Presentation

                                                              • Demographics

                                                                • Natural History & Prognosis

                                                                  • Treatment

                                                                    DIAGNOSTIC CHECKLIST

                                                                    • Image Interpretation Pearls

                                                                      Selected References

                                                                      1. Takeuchi M et al: Ovarian adenofibromas and cystadenofibromas: magnetic resonance imaging findings including diffusion-weighted imaging. Acta Radiol. 54(2):231-6, 2013
                                                                      2. Tang YZ et al: The MRI features of histologically proven ovarian cystadenofibromas-an assessment of the morphological and enhancement patterns. Eur Radiol. 23(1):48-56, 2013
                                                                      3. Khashper A et al: T2-hypointense adnexal lesions: an imaging algorithm. Radiographics. 32(4):1047-64, 2012
                                                                      4. Li W et al: Diffusion-weighted MRI: a useful technique to discriminate benign versus malignant ovarian surface epithelial tumors with solid and cystic components. Abdom Imaging. 37(5):897-903, 2012
                                                                      5. Takeuchi M et al: Diffusion-weighted magnetic resonance imaging of ovarian tumors: differentiation of benign and malignant solid components of ovarian masses. J Comput Assist Tomogr. 34(2):173-6, 2010
                                                                      6. Fujii S et al: Diagnostic accuracy of diffusion-weighted imaging in differentiating benign from malignant ovarian lesions. J Magn Reson Imaging. 28(5):1149-56, 2008
                                                                      7. Stanwell P et al: Evaluation of ovarian tumors by proton magnetic resonance spectroscopy at three Tesla. Invest Radiol. 43(10):745-51, 2008
                                                                      8. Jung DC et al: MR imaging findings of ovarian cystadenofibroma and cystadenocarcinofibroma: clues for the differential diagnosis. Korean J Radiol. 7(3):199-204, 2006
                                                                      9. Cho SM et al: CT and MRI findings of cystadenofibromas of the ovary. Eur Radiol. 14(5):798-804, 2004
                                                                      10. Kim KA et al: Benign ovarian tumors with solid and cystic components that mimic malignancy. AJR Am J Roentgenol. 182(5):1259-65, 2004
                                                                      11. Takeuchi M et al: Ovarian cystadenofibromas: characteristic magnetic resonance findings with pathologic correlation. J Comput Assist Tomogr. 27(6):871-3, 2003
                                                                      12. Jung SE et al: CT and MR imaging of ovarian tumors with emphasis on differential diagnosis. Radiographics. 22(6):1305-25, 2002
                                                                      13. Alcazar JL et al: Sonographic features of ovarian cystadenofibromas: spectrum of findings. J Ultrasound Med. 20(8):915-9, 2001
                                                                      14. Fatum M et al: Papillary serous cystadenofibroma of the ovary--is it really so rare? Int J Gynaecol Obstet. 75(1):85-6, 2001
                                                                      15. Outwater EK et al: Ovarian fibromas and cystadenofibromas: MRI features of the fibrous component. J Magn Reson Imaging. 7(3):465-71, 1997