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Adenoma Malignum
Christine O. Menias, MD; Oguz Akin, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Pathology

        • Clinical Issues

          TERMINOLOGY

          • Synonyms

            • Mucinous minimal deviation adenocarcinoma
              • Mucoid adenocarcinoma
          • Definitions

            • Subtype of mucinous adenocarcinoma of cervix
              • Termed malignum because of virulent and fatal progression of tumor

          IMAGING

          • General Features

            • CT Findings

              • MR Findings

                • Ultrasonographic Findings

                  • Nuclear Medicine Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        • Image Interpretation Pearls

                                          Selected References

                                          1. Mowat A et al: Adenoma malignum presenting as urinary incontinence. Int Urogynecol J. Epub ahead of print, 2014
                                          2. Cole AJ et al: Patterns of myoinvasion in endometrial adenocarcinoma: recognition and implications. Adv Anat Pathol. 20(3):141-7, 2013
                                          3. Guo F et al: Diagnostic challenges in minimal deviation adenocarcinoma of the uterine cervix: A report of two cases and review of the literature. Mol Clin Oncol. 1(5):833-838, 2013
                                          4. Khalbuss WE et al: Cytomorphology of unusual primary tumors in the Pap test. Cytojournal. 10:17, 2013
                                          5. Ki EY et al: Adenoma malignum of the uterine cervix: report of four cases. World J Surg Oncol. 11:168, 2013
                                          6. Kwon SY et al: Minimal deviation adenocarcinoma of the cervix and tumorlets of sex-cord stromal tumor with annular tubules of the ovary in Peutz-Jeghers syndrome. J Gynecol Oncol. 24(1):92-5, 2013
                                          7. McCluggage WG: New developments in endocervical glandular lesions. Histopathology. 62(1):138-60, 2013
                                          8. McCluggage WG: Premalignant lesions of the lower female genital tract: cervix, vagina and vulva. Pathology. 45(3):214-28, 2013
                                          9. McEachern J et al: Adenoma malignum detected on a trauma CT. J Radiol Case Rep. 7(4):22-8, 2013
                                          10. Park SB et al: Adenoma malignum of the uterine cervix: imaging features with clinicopathologic correlation. Acta Radiol. 54(1):113-20, 2013
                                          11. Dasgupta S et al: Adenoma malignum of the uterine cervix--an enigma. J Indian Med Assoc. 110(12):929-30, 2012
                                          12. Ito M et al: Peutz-Jeghers syndrome-associated atypical mucinous proliferation of the uterine cervix: a case of minimal deviation adenocarcinoma ('adenoma malignum') in situ. Pathol Res Pract. 208(10):623-7, 2012
                                          13. Lim KT et al: Adenoma malignum of the uterine cervix: Clinicopathologic analysis of 18 cases. Kaohsiung J Med Sci. 28(3):161-4, 2012
                                          14. Quick CM et al: Low-grade, low-stage endometrioid endometrial adenocarcinoma: a clinicopathologic analysis of 324 cases focusing on frequency and pattern of myoinvasion. Int J Gynecol Pathol. 31(4):337-43, 2012
                                          15. Shiozawa T: [Adenoma malignum and lobular endocervical glandular hyperplasia (LEGH).] Nihon Rinsho. 70 Suppl 4:114-21, 2012
                                          16. Park SB et al: Adenoma malignum of the uterine cervix: ultrasonographic findings in 11 patients. Ultrasound Obstet Gynecol. 38(6):716-21, 2011
                                          17. Sharp HJ et al: PET/CT in a patient with adenoma malignum of the uterine cervix. Clin Nucl Med. 36(6):468-9, 2011
                                          18. Takatsu A et al: Preoperative differential diagnosis of minimal deviation adenocarcinoma and lobular endocervical glandular hyperplasia of the uterine cervix: a multicenter study of clinicopathology and magnetic resonance imaging findings. Int J Gynecol Cancer. 21(7):1287-96, 2011
                                          19. Bin Park S et al: Multilocular cystic lesions in the uterine cervix: broad spectrum of imaging features and pathologic correlation. AJR Am J Roentgenol. 195(2):517-23, 2010
                                          20. Li G et al: Minimal deviation adenocarcinoma of the uterine cervix. Int J Gynaecol Obstet. 110(2):89-92, 2010
                                          21. Sugiyama K et al: MR findings of pseudoneoplastic lesions in the uterine cervix mimicking adenoma malignum. Br J Radiol. 80(959):878-83, 2007
                                          22. Ohta Y et al: Cytology, immunohistochemistry and 3-dimensional reconstruction of adenoma malignum: a case report. Acta Cytol. 49(2):181-6, 2005
                                          23. Oguri H et al: MRI of endocervical glandular disorders: three cases of a deep nabothian cyst and three cases of a minimal-deviation adenocarcinoma. Magn Reson Imaging. 22(9):1333-7, 2004
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Pathology

                                                • Clinical Issues

                                                  TERMINOLOGY

                                                  • Synonyms

                                                    • Mucinous minimal deviation adenocarcinoma
                                                      • Mucoid adenocarcinoma
                                                  • Definitions

                                                    • Subtype of mucinous adenocarcinoma of cervix
                                                      • Termed malignum because of virulent and fatal progression of tumor

                                                  IMAGING

                                                  • General Features

                                                    • CT Findings

                                                      • MR Findings

                                                        • Ultrasonographic Findings

                                                          • Nuclear Medicine Findings

                                                            • Imaging Recommendations

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • General Features

                                                                  • Gross Pathologic & Surgical Features

                                                                    • Microscopic Features

                                                                      CLINICAL ISSUES

                                                                      • Presentation

                                                                        • Demographics

                                                                          • Natural History & Prognosis

                                                                            • Treatment

                                                                              DIAGNOSTIC CHECKLIST

                                                                              • Consider

                                                                                • Image Interpretation Pearls

                                                                                  Selected References

                                                                                  1. Mowat A et al: Adenoma malignum presenting as urinary incontinence. Int Urogynecol J. Epub ahead of print, 2014
                                                                                  2. Cole AJ et al: Patterns of myoinvasion in endometrial adenocarcinoma: recognition and implications. Adv Anat Pathol. 20(3):141-7, 2013
                                                                                  3. Guo F et al: Diagnostic challenges in minimal deviation adenocarcinoma of the uterine cervix: A report of two cases and review of the literature. Mol Clin Oncol. 1(5):833-838, 2013
                                                                                  4. Khalbuss WE et al: Cytomorphology of unusual primary tumors in the Pap test. Cytojournal. 10:17, 2013
                                                                                  5. Ki EY et al: Adenoma malignum of the uterine cervix: report of four cases. World J Surg Oncol. 11:168, 2013
                                                                                  6. Kwon SY et al: Minimal deviation adenocarcinoma of the cervix and tumorlets of sex-cord stromal tumor with annular tubules of the ovary in Peutz-Jeghers syndrome. J Gynecol Oncol. 24(1):92-5, 2013
                                                                                  7. McCluggage WG: New developments in endocervical glandular lesions. Histopathology. 62(1):138-60, 2013
                                                                                  8. McCluggage WG: Premalignant lesions of the lower female genital tract: cervix, vagina and vulva. Pathology. 45(3):214-28, 2013
                                                                                  9. McEachern J et al: Adenoma malignum detected on a trauma CT. J Radiol Case Rep. 7(4):22-8, 2013
                                                                                  10. Park SB et al: Adenoma malignum of the uterine cervix: imaging features with clinicopathologic correlation. Acta Radiol. 54(1):113-20, 2013
                                                                                  11. Dasgupta S et al: Adenoma malignum of the uterine cervix--an enigma. J Indian Med Assoc. 110(12):929-30, 2012
                                                                                  12. Ito M et al: Peutz-Jeghers syndrome-associated atypical mucinous proliferation of the uterine cervix: a case of minimal deviation adenocarcinoma ('adenoma malignum') in situ. Pathol Res Pract. 208(10):623-7, 2012
                                                                                  13. Lim KT et al: Adenoma malignum of the uterine cervix: Clinicopathologic analysis of 18 cases. Kaohsiung J Med Sci. 28(3):161-4, 2012
                                                                                  14. Quick CM et al: Low-grade, low-stage endometrioid endometrial adenocarcinoma: a clinicopathologic analysis of 324 cases focusing on frequency and pattern of myoinvasion. Int J Gynecol Pathol. 31(4):337-43, 2012
                                                                                  15. Shiozawa T: [Adenoma malignum and lobular endocervical glandular hyperplasia (LEGH).] Nihon Rinsho. 70 Suppl 4:114-21, 2012
                                                                                  16. Park SB et al: Adenoma malignum of the uterine cervix: ultrasonographic findings in 11 patients. Ultrasound Obstet Gynecol. 38(6):716-21, 2011
                                                                                  17. Sharp HJ et al: PET/CT in a patient with adenoma malignum of the uterine cervix. Clin Nucl Med. 36(6):468-9, 2011
                                                                                  18. Takatsu A et al: Preoperative differential diagnosis of minimal deviation adenocarcinoma and lobular endocervical glandular hyperplasia of the uterine cervix: a multicenter study of clinicopathology and magnetic resonance imaging findings. Int J Gynecol Cancer. 21(7):1287-96, 2011
                                                                                  19. Bin Park S et al: Multilocular cystic lesions in the uterine cervix: broad spectrum of imaging features and pathologic correlation. AJR Am J Roentgenol. 195(2):517-23, 2010
                                                                                  20. Li G et al: Minimal deviation adenocarcinoma of the uterine cervix. Int J Gynaecol Obstet. 110(2):89-92, 2010
                                                                                  21. Sugiyama K et al: MR findings of pseudoneoplastic lesions in the uterine cervix mimicking adenoma malignum. Br J Radiol. 80(959):878-83, 2007
                                                                                  22. Ohta Y et al: Cytology, immunohistochemistry and 3-dimensional reconstruction of adenoma malignum: a case report. Acta Cytol. 49(2):181-6, 2005
                                                                                  23. Oguri H et al: MRI of endocervical glandular disorders: three cases of a deep nabothian cyst and three cases of a minimal-deviation adenocarcinoma. Magn Reson Imaging. 22(9):1333-7, 2004