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Adrenal Carcinoma
Mitchell Tublin, MD; Michael P. Federle, MD, FACR
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KEY FACTS

  • Imaging

    • Top Differential Diagnoses

      • Diagnostic Checklist

        TERMINOLOGY

        • Synonyms

          • Adrenocortical carcinoma, adrenal cancer
        • Definitions

          • Malignant growth from 1 adrenal cell line

        IMAGING

        • General Features

          • CT Findings

            • MR Findings

              • Ultrasonographic Findings

                • Angiographic Findings

                  • Nuclear Medicine Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Staging, Grading, & Classification

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          • Image Interpretation Pearls

                                            Selected References

                                            1. Ahmed AA et al: Adrenal cortical carcinoma: pathology, genomics, prognosis, imaging features, and mimics with impact on management. Abdom Radiol (NY). ePub, 2020
                                            2. Glazer DI et al: Management of incidental adrenal masses: an update. Abdom Radiol (NY). ePub, 2019
                                            3. Ranathunga DS et al: Macroscopic fat in adrenocortical carcinoma: a systematic review. AJR Am J Roentgenol. 1-5, 2019
                                            4. Zhang Z et al: Clinical analysis of adrenal lesions larger than 5 cm in diameter (an analysis of 251 cases). World J Surg Oncol. 17(1):220, 2019
                                            5. Fassnacht M et al: European Society of Endocrinology Clinical Practice Guidelines on the management of adrenocortical carcinoma in adults, in collaboration with the European Network for the Study of Adrenal Tumors Eur J Endocrinol. 179(4):G1-46, 2018
                                            6. Park SY et al: CT sensitivities for large (≥3 cm) adrenal adenoma and cortical carcinoma. Abdom Imaging. 40(2):310-7, 2015
                                            7. Bharwani N et al: Adrenocortical carcinoma: the range of appearances on CT and MRI. AJR Am J Roentgenol. 196(6):W706-14, 2011
                                            8. Slattery JM, Blake MA, Kalra MK, et al. Adrenocortical carcinoma: washout characteristics on CT. Am J Roentgenol. 2006;187:W21–4
                                            Related Anatomy
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                                            Related Differential Diagnoses
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                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Imaging

                                              • Top Differential Diagnoses

                                                • Diagnostic Checklist

                                                  TERMINOLOGY

                                                  • Synonyms

                                                    • Adrenocortical carcinoma, adrenal cancer
                                                  • Definitions

                                                    • Malignant growth from 1 adrenal cell line

                                                  IMAGING

                                                  • General Features

                                                    • CT Findings

                                                      • MR Findings

                                                        • Ultrasonographic Findings

                                                          • Angiographic Findings

                                                            • Nuclear Medicine Findings

                                                              • Imaging Recommendations

                                                                DIFFERENTIAL DIAGNOSIS

                                                                  PATHOLOGY

                                                                  • General Features

                                                                    • Staging, Grading, & Classification

                                                                      • Gross Pathologic & Surgical Features

                                                                        • Microscopic Features

                                                                          CLINICAL ISSUES

                                                                          • Presentation

                                                                            • Demographics

                                                                              • Natural History & Prognosis

                                                                                • Treatment

                                                                                  DIAGNOSTIC CHECKLIST

                                                                                  • Consider

                                                                                    • Image Interpretation Pearls

                                                                                      Selected References

                                                                                      1. Ahmed AA et al: Adrenal cortical carcinoma: pathology, genomics, prognosis, imaging features, and mimics with impact on management. Abdom Radiol (NY). ePub, 2020
                                                                                      2. Glazer DI et al: Management of incidental adrenal masses: an update. Abdom Radiol (NY). ePub, 2019
                                                                                      3. Ranathunga DS et al: Macroscopic fat in adrenocortical carcinoma: a systematic review. AJR Am J Roentgenol. 1-5, 2019
                                                                                      4. Zhang Z et al: Clinical analysis of adrenal lesions larger than 5 cm in diameter (an analysis of 251 cases). World J Surg Oncol. 17(1):220, 2019
                                                                                      5. Fassnacht M et al: European Society of Endocrinology Clinical Practice Guidelines on the management of adrenocortical carcinoma in adults, in collaboration with the European Network for the Study of Adrenal Tumors Eur J Endocrinol. 179(4):G1-46, 2018
                                                                                      6. Park SY et al: CT sensitivities for large (≥3 cm) adrenal adenoma and cortical carcinoma. Abdom Imaging. 40(2):310-7, 2015
                                                                                      7. Bharwani N et al: Adrenocortical carcinoma: the range of appearances on CT and MRI. AJR Am J Roentgenol. 196(6):W706-14, 2011
                                                                                      8. Slattery JM, Blake MA, Kalra MK, et al. Adrenocortical carcinoma: washout characteristics on CT. Am J Roentgenol. 2006;187:W21–4