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Adrenal Collision Tumor
Mitchell Tublin, MD; Mark D. Sugi, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Diagnostic Checklist

          TERMINOLOGY

          • Abbreviations

            • Adrenal collision tumor (ACT)
          • Definitions

            • Coexistence of 2 contiguous but histologically different tumors within same adrenal gland
            • Not composite tumor (i.e., tumor with intermixed, differing cell types)

          IMAGING

          • General Features

            • CT Findings

              • MR Findings

                • Nuclear Medicine Findings

                  • Imaging Recommendations

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Gross Pathologic & Surgical Features

                          • Microscopic Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  DIAGNOSTIC CHECKLIST

                                  • Consider

                                    Selected References

                                    1. Zhou C et al: Functional adrenal collision tumor in a patient with Cushing's syndrome. Case Rep Endocrinol. 2020:7415762, 2020
                                    2. Akkuş G et al: Diagnostic efficacy of 18F-FDG PET/CT in patients with adrenal incidentaloma. Endocr Connect. 8(7):838-45, 2019
                                    3. Cicero G et al: Collision and composition tumors: rare conditions to remember in differential diagnosis of adrenal glands lesions. Quant Imaging Med Surg. 9(11):1902-3, 2019
                                    4. Foresti M et al: Adrenal adenoma-hemangioma collision tumor: description of two cases. J Radiol Case Rep. 13(6):1-12, 2019
                                    5. Pakalniskis MG et al: Adrenal collision tumour comprised of adrenocortical carcinoma and myelolipoma in a patient with congenital adrenal hyperplasia. J Med Imaging Radiat Oncol. 64(1):67-8, 2019
                                    6. Khorsand A et al: Adrenal collision tumor composed of pheochromocytoma and diffuse large B-cell lymphoma: a case report. Int J Hematol Oncol Stem Cell Res. 12(4):249-52, 2018
                                    7. Sung CT et al: Collision and composite tumors; radiologic and pathologic correlation. Abdom Radiol (NY). 42(12):2909-26, 2017
                                    8. Diolombi ML et al: Diagnostic dilemmas in enlarged and diffusely hemorrhagic adrenal glands. Hum Pathol. 53:63-72, 2016
                                    9. Lee HS et al: Adrenal collision tumor: coexistence of pigmented adrenal cortical oncocytoma and ganglioneuroma. Case Rep Surg. 2016:5790645, 2016
                                    10. Piotrowski Z et al: Renal cell carcinoma and an incidental adrenal lesion: adrenal collision tumors. Urology. 85(3):e17-8, 2015
                                    11. Shida Y et al: Composite pheochromocytoma of the adrenal gland: a case series. BMC Res Notes. 8:257, 2015
                                    12. Untch BR et al: Imaging and management of a small cell lung cancer metastasis/adrenal adenoma collision tumor: a case report and review of the literature. World J Surg Oncol. 12:45, 2014
                                    13. Katabathina VS et al: Adrenal collision tumors and their mimics: multimodality imaging findings. Cancer Imaging. 13(4):602-10, 2013
                                    14. Anderson SB et al: Adrenal collision tumor diagnosed by F-18 fluorodeoxyglucose PET/CT. Clin Nucl Med. 35(6):414-7, 2010
                                    15. Blake MA et al: Collision adrenal tumors on PET/CT. AJR Am J Roentgenol. 183(3):864-5, 2004
                                    Related Anatomy
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                                    Related Differential Diagnoses
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                                    References
                                    Tables

                                    Tables

                                    KEY FACTS

                                    • Terminology

                                      • Imaging

                                        • Top Differential Diagnoses

                                          • Diagnostic Checklist

                                            TERMINOLOGY

                                            • Abbreviations

                                              • Adrenal collision tumor (ACT)
                                            • Definitions

                                              • Coexistence of 2 contiguous but histologically different tumors within same adrenal gland
                                              • Not composite tumor (i.e., tumor with intermixed, differing cell types)

                                            IMAGING

                                            • General Features

                                              • CT Findings

                                                • MR Findings

                                                  • Nuclear Medicine Findings

                                                    • Imaging Recommendations

                                                      DIFFERENTIAL DIAGNOSIS

                                                        PATHOLOGY

                                                        • General Features

                                                          • Gross Pathologic & Surgical Features

                                                            • Microscopic Features

                                                              CLINICAL ISSUES

                                                              • Presentation

                                                                • Demographics

                                                                  • Natural History & Prognosis

                                                                    DIAGNOSTIC CHECKLIST

                                                                    • Consider

                                                                      Selected References

                                                                      1. Zhou C et al: Functional adrenal collision tumor in a patient with Cushing's syndrome. Case Rep Endocrinol. 2020:7415762, 2020
                                                                      2. Akkuş G et al: Diagnostic efficacy of 18F-FDG PET/CT in patients with adrenal incidentaloma. Endocr Connect. 8(7):838-45, 2019
                                                                      3. Cicero G et al: Collision and composition tumors: rare conditions to remember in differential diagnosis of adrenal glands lesions. Quant Imaging Med Surg. 9(11):1902-3, 2019
                                                                      4. Foresti M et al: Adrenal adenoma-hemangioma collision tumor: description of two cases. J Radiol Case Rep. 13(6):1-12, 2019
                                                                      5. Pakalniskis MG et al: Adrenal collision tumour comprised of adrenocortical carcinoma and myelolipoma in a patient with congenital adrenal hyperplasia. J Med Imaging Radiat Oncol. 64(1):67-8, 2019
                                                                      6. Khorsand A et al: Adrenal collision tumor composed of pheochromocytoma and diffuse large B-cell lymphoma: a case report. Int J Hematol Oncol Stem Cell Res. 12(4):249-52, 2018
                                                                      7. Sung CT et al: Collision and composite tumors; radiologic and pathologic correlation. Abdom Radiol (NY). 42(12):2909-26, 2017
                                                                      8. Diolombi ML et al: Diagnostic dilemmas in enlarged and diffusely hemorrhagic adrenal glands. Hum Pathol. 53:63-72, 2016
                                                                      9. Lee HS et al: Adrenal collision tumor: coexistence of pigmented adrenal cortical oncocytoma and ganglioneuroma. Case Rep Surg. 2016:5790645, 2016
                                                                      10. Piotrowski Z et al: Renal cell carcinoma and an incidental adrenal lesion: adrenal collision tumors. Urology. 85(3):e17-8, 2015
                                                                      11. Shida Y et al: Composite pheochromocytoma of the adrenal gland: a case series. BMC Res Notes. 8:257, 2015
                                                                      12. Untch BR et al: Imaging and management of a small cell lung cancer metastasis/adrenal adenoma collision tumor: a case report and review of the literature. World J Surg Oncol. 12:45, 2014
                                                                      13. Katabathina VS et al: Adrenal collision tumors and their mimics: multimodality imaging findings. Cancer Imaging. 13(4):602-10, 2013
                                                                      14. Anderson SB et al: Adrenal collision tumor diagnosed by F-18 fluorodeoxyglucose PET/CT. Clin Nucl Med. 35(6):414-7, 2010
                                                                      15. Blake MA et al: Collision adrenal tumors on PET/CT. AJR Am J Roentgenol. 183(3):864-5, 2004