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Adrenal Lymphoma
Mitchell Tublin, MD; Mark D. Sugi, MD
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KEY FACTS

  • Imaging

    • Top Differential Diagnoses

      • Pathology

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Abbreviations

              • Primary adrenal lymphoma (PAL)
            • Definitions

              • Histologically confirmed lymphoma involving 1 or both adrenal glands
                • No prior history of lymphoma
                • If other visceral or nodal involvement, adrenal disease is dominant

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  • Ultrasonographic Findings

                    • Nuclear Medicine Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Staging, Grading, & Classification

                              • Gross Pathologic & Surgical Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Image Interpretation Pearls

                                          Selected References

                                          1. Alshahrani MA et al: Bilateral adrenal abnormalities: imaging review of different entities. Abdom Radiol (NY). 44(1):154-79, 2019
                                          2. Yang L et al: Correlations between MDCT features and clinicopathological findings of primary adrenal lymphoma. Eur J Radiol. 113:110-5, 2019
                                          3. Joseph FG et al: Primary adrenal lymphoma with initial presentation concerning for bilateral adrenal pheochromocytomas. BMJ Case Rep. 2017, 2017
                                          4. Laurent C et al: Adrenal lymphoma: presentation, management and prognosis. QJM. 110(2):103-9, 2017
                                          5. Meyyur Aravamudan V et al: A rare case of primary bilateral adrenal lymphoma. Case Rep Med. 2017:1251950, 2017
                                          6. Ekhzaimy A et al: Bilateral primary adrenal lymphoma with adrenal insufficiency. BMJ Case Rep. 2016, 2016
                                          7. Rohena-Quinquilla IR et al: Imaging of extranodal genitourinary lymphoma. Radiol Clin North Am. 54(4):747-64, 2016
                                          8. Rashidi A et al: Primary adrenal lymphoma: a systematic review. Ann Hematol. 92(12):1583-93, 2013
                                          9. Zhou L et al: Primary adrenal lymphoma: radiological; pathological, clinical correlation. Eur J Radiol. 81(3):401-5, 2012
                                          10. Blake MA et al: Adrenal imaging. AJR Am J Roentgenol. 194(6):1450-60, 2010
                                          11. Leite NP et al: Cross-sectional imaging of extranodal involvement in abdominopelvic lymphoproliferative malignancies. Radiographics. 27(6):1613-34, 2007
                                          12. Lockhart ME et al: Imaging of adrenal masses. Eur J Radiol. 41(2):95-112, 2002
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Imaging

                                            • Top Differential Diagnoses

                                              • Pathology

                                                • Clinical Issues

                                                  • Diagnostic Checklist

                                                    TERMINOLOGY

                                                    • Abbreviations

                                                      • Primary adrenal lymphoma (PAL)
                                                    • Definitions

                                                      • Histologically confirmed lymphoma involving 1 or both adrenal glands
                                                        • No prior history of lymphoma
                                                        • If other visceral or nodal involvement, adrenal disease is dominant

                                                    IMAGING

                                                    • General Features

                                                      • CT Findings

                                                        • MR Findings

                                                          • Ultrasonographic Findings

                                                            • Nuclear Medicine Findings

                                                              • Imaging Recommendations

                                                                DIFFERENTIAL DIAGNOSIS

                                                                  PATHOLOGY

                                                                  • General Features

                                                                    • Staging, Grading, & Classification

                                                                      • Gross Pathologic & Surgical Features

                                                                        CLINICAL ISSUES

                                                                        • Presentation

                                                                          • Demographics

                                                                            • Natural History & Prognosis

                                                                              • Treatment

                                                                                DIAGNOSTIC CHECKLIST

                                                                                • Image Interpretation Pearls

                                                                                  Selected References

                                                                                  1. Alshahrani MA et al: Bilateral adrenal abnormalities: imaging review of different entities. Abdom Radiol (NY). 44(1):154-79, 2019
                                                                                  2. Yang L et al: Correlations between MDCT features and clinicopathological findings of primary adrenal lymphoma. Eur J Radiol. 113:110-5, 2019
                                                                                  3. Joseph FG et al: Primary adrenal lymphoma with initial presentation concerning for bilateral adrenal pheochromocytomas. BMJ Case Rep. 2017, 2017
                                                                                  4. Laurent C et al: Adrenal lymphoma: presentation, management and prognosis. QJM. 110(2):103-9, 2017
                                                                                  5. Meyyur Aravamudan V et al: A rare case of primary bilateral adrenal lymphoma. Case Rep Med. 2017:1251950, 2017
                                                                                  6. Ekhzaimy A et al: Bilateral primary adrenal lymphoma with adrenal insufficiency. BMJ Case Rep. 2016, 2016
                                                                                  7. Rohena-Quinquilla IR et al: Imaging of extranodal genitourinary lymphoma. Radiol Clin North Am. 54(4):747-64, 2016
                                                                                  8. Rashidi A et al: Primary adrenal lymphoma: a systematic review. Ann Hematol. 92(12):1583-93, 2013
                                                                                  9. Zhou L et al: Primary adrenal lymphoma: radiological; pathological, clinical correlation. Eur J Radiol. 81(3):401-5, 2012
                                                                                  10. Blake MA et al: Adrenal imaging. AJR Am J Roentgenol. 194(6):1450-60, 2010
                                                                                  11. Leite NP et al: Cross-sectional imaging of extranodal involvement in abdominopelvic lymphoproliferative malignancies. Radiographics. 27(6):1613-34, 2007
                                                                                  12. Lockhart ME et al: Imaging of adrenal masses. Eur J Radiol. 41(2):95-112, 2002