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Adrenocortical Carcinoma
Alexander J. Towbin, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Adrenocortical carcinoma (ACC)
            • Definitions

              • Malignant adrenal cortical neoplasm

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Ultrasonographic Findings

                      • Nuclear Medicine Findings

                        • Imaging Recommendations

                          DIFFERENTIAL DIAGNOSIS

                            PATHOLOGY

                            • General Features

                              • Staging, Grading, & Classification

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Image Interpretation Pearls

                                          Selected References

                                          1. Al-Sarhani H et al: Screening of cancer predisposition syndromes. Pediatr Radiol. ePub, 2021
                                          2. Hanafy AK et al: Imaging features of adrenal gland masses in the pediatric population. Abdom Radiol (NY). 45(4):964-81, 2020
                                          3. Gupta N et al: Adrenocortical carcinoma in children: a clinicopathological analysis of 41 patients at the Mayo Clinic from 1950 to 2017. Horm Res Paediatr. 90(1):8-18, 2018
                                          4. Bulzico D et al: Recurrence and mortality prognostic factors in childhood adrenocortical tumors: analysis from the Brazilian National Institute of Cancer experience. Pediatr Hematol Oncol. 33(4):248-58, 2016
                                          5. Gulack BC et al: Factors associated with survival in pediatric adrenocortical carcinoma: an analysis of the National Cancer Data Base (NCDB). J Pediatr Surg. 51(1):172-7, 2016
                                          6. Sabaretnam M et al: Adrenocortical carcinoma in children and adults: two decades experience in a single institution. Indian J Cancer. 53(2):317-321, 2016
                                          7. Flynt KA et al: Pediatric adrenocortical neoplasms: can imaging reliably discriminate adenomas from carcinomas? Pediatr Radiol. 45(8):1160-8, 2015
                                          8. Wasserman JD et al: Prevalence and functional consequence of TP53 mutations in pediatric adrenocortical carcinoma: a children's oncology group study. J Clin Oncol. 33(6):602-9, 2015
                                          9. Kerkhofs TM et al: Adrenocortical carcinoma in children: first population-based clinicopathological study with long-term follow-up. Oncol Rep. 32(6):2836-44, 2014
                                          10. Sakoda A et al: Clinical and histopathological features of adrenocortical neoplasms in children: retrospective review from a single specialist center. J Pediatr Surg. 49(3):410-5, 2014
                                          11. Ribeiro J et al: Imaging findings in pediatric adrenocortical carcinoma. Pediatr Radiol. 30(1):45-51, 2000
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Top Differential Diagnoses

                                                • Pathology

                                                  • Clinical Issues

                                                    TERMINOLOGY

                                                    • Abbreviations

                                                      • Adrenocortical carcinoma (ACC)
                                                    • Definitions

                                                      • Malignant adrenal cortical neoplasm

                                                    IMAGING

                                                    • General Features

                                                      • Radiographic Findings

                                                        • CT Findings

                                                          • MR Findings

                                                            • Ultrasonographic Findings

                                                              • Nuclear Medicine Findings

                                                                • Imaging Recommendations

                                                                  DIFFERENTIAL DIAGNOSIS

                                                                    PATHOLOGY

                                                                    • General Features

                                                                      • Staging, Grading, & Classification

                                                                        CLINICAL ISSUES

                                                                        • Presentation

                                                                          • Demographics

                                                                            • Natural History & Prognosis

                                                                              • Treatment

                                                                                DIAGNOSTIC CHECKLIST

                                                                                • Image Interpretation Pearls

                                                                                  Selected References

                                                                                  1. Al-Sarhani H et al: Screening of cancer predisposition syndromes. Pediatr Radiol. ePub, 2021
                                                                                  2. Hanafy AK et al: Imaging features of adrenal gland masses in the pediatric population. Abdom Radiol (NY). 45(4):964-81, 2020
                                                                                  3. Gupta N et al: Adrenocortical carcinoma in children: a clinicopathological analysis of 41 patients at the Mayo Clinic from 1950 to 2017. Horm Res Paediatr. 90(1):8-18, 2018
                                                                                  4. Bulzico D et al: Recurrence and mortality prognostic factors in childhood adrenocortical tumors: analysis from the Brazilian National Institute of Cancer experience. Pediatr Hematol Oncol. 33(4):248-58, 2016
                                                                                  5. Gulack BC et al: Factors associated with survival in pediatric adrenocortical carcinoma: an analysis of the National Cancer Data Base (NCDB). J Pediatr Surg. 51(1):172-7, 2016
                                                                                  6. Sabaretnam M et al: Adrenocortical carcinoma in children and adults: two decades experience in a single institution. Indian J Cancer. 53(2):317-321, 2016
                                                                                  7. Flynt KA et al: Pediatric adrenocortical neoplasms: can imaging reliably discriminate adenomas from carcinomas? Pediatr Radiol. 45(8):1160-8, 2015
                                                                                  8. Wasserman JD et al: Prevalence and functional consequence of TP53 mutations in pediatric adrenocortical carcinoma: a children's oncology group study. J Clin Oncol. 33(6):602-9, 2015
                                                                                  9. Kerkhofs TM et al: Adrenocortical carcinoma in children: first population-based clinicopathological study with long-term follow-up. Oncol Rep. 32(6):2836-44, 2014
                                                                                  10. Sakoda A et al: Clinical and histopathological features of adrenocortical neoplasms in children: retrospective review from a single specialist center. J Pediatr Surg. 49(3):410-5, 2014
                                                                                  11. Ribeiro J et al: Imaging findings in pediatric adrenocortical carcinoma. Pediatr Radiol. 30(1):45-51, 2000