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Adult Still Disease
B.J. Manaster, MD, PhD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          TERMINOLOGY

          • Synonyms

            • Wissler-Fanconi syndrome, subsepsis hyperallergica
          • Definitions

            • Systemic inflammatory disease, featuring triad
              • Quotidian fevers (spiking, daily)
              • Evanescent rash
              • Chronic polyarthritis
            • Considered adult continuum of juvenile idiopathic arthritis (JIA)

          IMAGING

          • General Features

            • Radiographic Findings

              • CT Findings

                • MR Findings

                  • Ultrasonographic Findings

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Microscopic Features

                          • Diagnostic Criteria (After Cush)

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Image Interpretation Pearls

                                      Selected References

                                      1. Dong MJ et al: 18F-FDG PET/CT in patients with adult-onset Still's disease. Clin Rheumatol. 34(12):2047-56, 2015
                                      2. Kadavath S et al: Adult-onset Still's disease-pathogenesis, clinical manifestations, and new treatment options. Ann Med. 47(1):6-14, 2015
                                      3. Manzini CU et al: Elevated Troponin Serum Levels in Adult Onset Still's Disease. Case Rep Rheumatol. 2015:732095, 2015
                                      4. Hayem F: Is Still's disease an autoinflammatory syndrome? Joint Bone Spine. 76(1):7-9, 2009
                                      5. Jadhav P et al: Myocarditis in adult onset Stills disease. Int J Rheum Dis. 12(3):272-4, 2009
                                      6. Lee SW et al: The mid-range of the adjusted level of ferritin can predict the chronic course in patients with adult onset Still's disease. J Rheumatol. 36(1):156-62, 2009
                                      7. Efthimiou P et al: Autoinflammatory syndromes and infections: pathogenetic and clinical implications. Clin Exp Rheumatol. 26(1 Suppl 48):S53-61, 2008
                                      8. Fautrel B: Adult-onset Still disease. Best Pract Res Clin Rheumatol. 22(5):773-92, 2008
                                      9. Kontzias A et al: Adult-onset Still's disease: pathogenesis, clinical manifestations and therapeutic advances. Drugs. 68(3):319-37, 2008
                                      10. Singh S et al: Adult onset Still's disease: a study of 14 cases. Clin Rheumatol. 27(1):35-9, 2008
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Top Differential Diagnoses

                                            • Clinical Issues

                                              TERMINOLOGY

                                              • Synonyms

                                                • Wissler-Fanconi syndrome, subsepsis hyperallergica
                                              • Definitions

                                                • Systemic inflammatory disease, featuring triad
                                                  • Quotidian fevers (spiking, daily)
                                                  • Evanescent rash
                                                  • Chronic polyarthritis
                                                • Considered adult continuum of juvenile idiopathic arthritis (JIA)

                                              IMAGING

                                              • General Features

                                                • Radiographic Findings

                                                  • CT Findings

                                                    • MR Findings

                                                      • Ultrasonographic Findings

                                                        DIFFERENTIAL DIAGNOSIS

                                                          PATHOLOGY

                                                          • General Features

                                                            • Microscopic Features

                                                              • Diagnostic Criteria (After Cush)

                                                                CLINICAL ISSUES

                                                                • Presentation

                                                                  • Demographics

                                                                    • Natural History & Prognosis

                                                                      • Treatment

                                                                        DIAGNOSTIC CHECKLIST

                                                                        • Image Interpretation Pearls

                                                                          Selected References

                                                                          1. Dong MJ et al: 18F-FDG PET/CT in patients with adult-onset Still's disease. Clin Rheumatol. 34(12):2047-56, 2015
                                                                          2. Kadavath S et al: Adult-onset Still's disease-pathogenesis, clinical manifestations, and new treatment options. Ann Med. 47(1):6-14, 2015
                                                                          3. Manzini CU et al: Elevated Troponin Serum Levels in Adult Onset Still's Disease. Case Rep Rheumatol. 2015:732095, 2015
                                                                          4. Hayem F: Is Still's disease an autoinflammatory syndrome? Joint Bone Spine. 76(1):7-9, 2009
                                                                          5. Jadhav P et al: Myocarditis in adult onset Stills disease. Int J Rheum Dis. 12(3):272-4, 2009
                                                                          6. Lee SW et al: The mid-range of the adjusted level of ferritin can predict the chronic course in patients with adult onset Still's disease. J Rheumatol. 36(1):156-62, 2009
                                                                          7. Efthimiou P et al: Autoinflammatory syndromes and infections: pathogenetic and clinical implications. Clin Exp Rheumatol. 26(1 Suppl 48):S53-61, 2008
                                                                          8. Fautrel B: Adult-onset Still disease. Best Pract Res Clin Rheumatol. 22(5):773-92, 2008
                                                                          9. Kontzias A et al: Adult-onset Still's disease: pathogenesis, clinical manifestations and therapeutic advances. Drugs. 68(3):319-37, 2008
                                                                          10. Singh S et al: Adult onset Still's disease: a study of 14 cases. Clin Rheumatol. 27(1):35-9, 2008