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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Agenesis of corpus callosum (ACC)
Definitions
- Failure of axons to cross midline and form corpus callosum (CC)
- Agenesis: Complete absence of CC
- Hypogenesis: Partial or incomplete formation of CC
- More common than dysgenesis
- Dysgenesis: Abnormal development of CC (e.g., callosal abnormalities seen in holoprosencephaly)
- Failure of axons to cross midline and form corpus callosum (CC)
IMAGING
General Features
Ultrasonographic Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Stoll C et al: Associated anomalies in cases with agenesis of the corpus callosum. Am J Med Genet A. 179(10):2101-11, 2019
- des Portes V et al: Outcome of isolated agenesis of the corpus callosum: a population-based prospective study. Eur J Paediatr Neurol. 22(1):82-92, 2018
- Manevich-Mazor M et al: Added value of fetal MRI in the evaluation of fetal anomalies of the corpus callosum: a retrospective analysis of 78 cases. Ultraschall Med. 39(5):513-25, 2018
- Griffiths PD et al: Use of MRI in the diagnosis of fetal brain abnormalities in utero (MERIDIAN): a multicentre, prospective cohort study. Lancet. 389(10068):538-546, 2017
- Rüland AM et al: Prenatal diagnosis of anomalies of the corpus callosum over a 13-year period. Ultraschall Med. 37(6):598-603, 2016
- Craven I et al: Antenatal diagnosis of agenesis of the corpus callosum. Clin Radiol. 70(3):248-53, 2015
- Noguchi R et al: Outcomes of patients with prenatally diagnosed agenesis of the corpus callosum in conjunction with ventriculomegaly. Arch Gynecol Obstet. 290(2):237-42, 2014
- Paladini D et al: Agenesis of the fetal corpus callosum: sonographic signs change with advancing gestational age. Ultrasound Obstet Gynecol. 42(6):687-90, 2013
- Santo S et al: Counseling in fetal medicine: agenesis of the corpus callosum. Ultrasound Obstet Gynecol. 40(5):513-21, 2012
- Ghi T et al: Prenatal diagnosis and outcome of partial agenesis and hypoplasia of the corpus callosum. Ultrasound Obstet Gynecol. 35(1):35-41, 2010
- Hosny IA et al: Ultrafast MRI of the fetus: an increasingly important tool in prenatal diagnosis of congenital anomalies. Magn Reson Imaging. 28(10):1431-9, 2010
- Winter TC et al: The cavum septi pellucidi: why is it important? J Ultrasound Med. 29(3):427-44, 2010
- Glenn OA et al: Fetal magnetic resonance imaging in the evaluation of fetuses referred for sonographically suspected abnormalities of the corpus callosum. J Ultrasound Med. 24(6):791-804, 2005
- Weinstein AS et al: In utero disappearance of the corpus callosum secondary to extensive brain injury. J Ultrasound Med. 22(8):837-40, 2003
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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
- Agenesis of corpus callosum (ACC)
Definitions
- Failure of axons to cross midline and form corpus callosum (CC)
- Agenesis: Complete absence of CC
- Hypogenesis: Partial or incomplete formation of CC
- More common than dysgenesis
- Dysgenesis: Abnormal development of CC (e.g., callosal abnormalities seen in holoprosencephaly)
- Failure of axons to cross midline and form corpus callosum (CC)
IMAGING
General Features
Ultrasonographic Findings
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Stoll C et al: Associated anomalies in cases with agenesis of the corpus callosum. Am J Med Genet A. 179(10):2101-11, 2019
- des Portes V et al: Outcome of isolated agenesis of the corpus callosum: a population-based prospective study. Eur J Paediatr Neurol. 22(1):82-92, 2018
- Manevich-Mazor M et al: Added value of fetal MRI in the evaluation of fetal anomalies of the corpus callosum: a retrospective analysis of 78 cases. Ultraschall Med. 39(5):513-25, 2018
- Griffiths PD et al: Use of MRI in the diagnosis of fetal brain abnormalities in utero (MERIDIAN): a multicentre, prospective cohort study. Lancet. 389(10068):538-546, 2017
- Rüland AM et al: Prenatal diagnosis of anomalies of the corpus callosum over a 13-year period. Ultraschall Med. 37(6):598-603, 2016
- Craven I et al: Antenatal diagnosis of agenesis of the corpus callosum. Clin Radiol. 70(3):248-53, 2015
- Noguchi R et al: Outcomes of patients with prenatally diagnosed agenesis of the corpus callosum in conjunction with ventriculomegaly. Arch Gynecol Obstet. 290(2):237-42, 2014
- Paladini D et al: Agenesis of the fetal corpus callosum: sonographic signs change with advancing gestational age. Ultrasound Obstet Gynecol. 42(6):687-90, 2013
- Santo S et al: Counseling in fetal medicine: agenesis of the corpus callosum. Ultrasound Obstet Gynecol. 40(5):513-21, 2012
- Ghi T et al: Prenatal diagnosis and outcome of partial agenesis and hypoplasia of the corpus callosum. Ultrasound Obstet Gynecol. 35(1):35-41, 2010
- Hosny IA et al: Ultrafast MRI of the fetus: an increasingly important tool in prenatal diagnosis of congenital anomalies. Magn Reson Imaging. 28(10):1431-9, 2010
- Winter TC et al: The cavum septi pellucidi: why is it important? J Ultrasound Med. 29(3):427-44, 2010
- Glenn OA et al: Fetal magnetic resonance imaging in the evaluation of fetuses referred for sonographically suspected abnormalities of the corpus callosum. J Ultrasound Med. 24(6):791-804, 2005
- Weinstein AS et al: In utero disappearance of the corpus callosum secondary to extensive brain injury. J Ultrasound Med. 22(8):837-40, 2003
