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Alcoholic Liver Disease
Atif Zaheer, MD; Michael P. Federle, MD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Abbreviations

              • Alcoholic liver disease (ALD)
            • Definitions

              • Hepatocyte injury and inflammation resulting from chronic alcohol consumption

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  • Ultrasonographic Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        Selected References

                                        1. Erden A et al: MRI quantification techniques in fatty liver: the diagnostic performance of hepatic T1, T2, and stiffness measurements in relation to the proton density fat fraction. Diagn Interv Radiol. 27(1):7-14, 2021
                                        2. Grillet F et al: Non-invasive diagnosis of severe alcoholic hepatitis: Usefulness of cross-sectional imaging. Diagn Interv Imaging.102(4):247-54, 2020
                                        3. Thomaides-Brears HB et al: Multiparametric MR mapping in clinical decision-making for diffuse liver disease. Abdom Radiol (NY). 45(11):3507-22, 2020
                                        4. Bradley CR et al: Multi-organ assessment of compensated cirrhosis patients using quantitative magnetic resonance imaging. J Hepatol. 69(5):1015-24, 2018
                                        5. Seitz HK et al: Alcoholic liver disease. Nat Rev Dis Primers. 4(1):16, 2018
                                        6. Liangpunsakul S et al: The alcoholic hepatitis histologic score: structured prognostic biopsy evaluation comes to alcoholic hepatitis. Gastroenterology. 146(5):1156-8, 2014
                                        7. Stickel F et al: Genetic determinants of alcoholic liver disease. Gut. 61(1):150-9, 2012
                                        8. Gao B et al: Alcoholic liver disease: pathogenesis and new therapeutic targets. Gastroenterology. 141(5):1572-85, 2011
                                        9. Reeder SB et al: Quantitative assessment of liver fat with magnetic resonance imaging and spectroscopy. J Magn Reson Imaging. 34(4):729-49, 2011
                                        10. Boll DT et al: Diffuse liver disease: strategies for hepatic CT and MR imaging. Radiographics. 29(6):1591-614, 2009
                                        11. Bahl M et al: Liver steatosis: investigation of opposed-phase T1-weighted liver MR signal intensity loss and visceral fat measurement as biomarkers. Radiology. 249(1):160-6, 2008
                                        12. Hamer OW et al: Imaging features of perivascular fatty infiltration of the liver: initial observations. Radiology. 237(1):159-69, 2005
                                        Related Anatomy
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                                        Related Differential Diagnoses
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Terminology

                                          • Imaging

                                            • Top Differential Diagnoses

                                              • Pathology

                                                • Clinical Issues

                                                  TERMINOLOGY

                                                  • Abbreviations

                                                    • Alcoholic liver disease (ALD)
                                                  • Definitions

                                                    • Hepatocyte injury and inflammation resulting from chronic alcohol consumption

                                                  IMAGING

                                                  • General Features

                                                    • CT Findings

                                                      • MR Findings

                                                        • Ultrasonographic Findings

                                                          • Imaging Recommendations

                                                            DIFFERENTIAL DIAGNOSIS

                                                              PATHOLOGY

                                                              • General Features

                                                                • Gross Pathologic & Surgical Features

                                                                  • Microscopic Features

                                                                    CLINICAL ISSUES

                                                                    • Presentation

                                                                      • Demographics

                                                                        • Natural History & Prognosis

                                                                          • Treatment

                                                                            DIAGNOSTIC CHECKLIST

                                                                            • Consider

                                                                              Selected References

                                                                              1. Erden A et al: MRI quantification techniques in fatty liver: the diagnostic performance of hepatic T1, T2, and stiffness measurements in relation to the proton density fat fraction. Diagn Interv Radiol. 27(1):7-14, 2021
                                                                              2. Grillet F et al: Non-invasive diagnosis of severe alcoholic hepatitis: Usefulness of cross-sectional imaging. Diagn Interv Imaging.102(4):247-54, 2020
                                                                              3. Thomaides-Brears HB et al: Multiparametric MR mapping in clinical decision-making for diffuse liver disease. Abdom Radiol (NY). 45(11):3507-22, 2020
                                                                              4. Bradley CR et al: Multi-organ assessment of compensated cirrhosis patients using quantitative magnetic resonance imaging. J Hepatol. 69(5):1015-24, 2018
                                                                              5. Seitz HK et al: Alcoholic liver disease. Nat Rev Dis Primers. 4(1):16, 2018
                                                                              6. Liangpunsakul S et al: The alcoholic hepatitis histologic score: structured prognostic biopsy evaluation comes to alcoholic hepatitis. Gastroenterology. 146(5):1156-8, 2014
                                                                              7. Stickel F et al: Genetic determinants of alcoholic liver disease. Gut. 61(1):150-9, 2012
                                                                              8. Gao B et al: Alcoholic liver disease: pathogenesis and new therapeutic targets. Gastroenterology. 141(5):1572-85, 2011
                                                                              9. Reeder SB et al: Quantitative assessment of liver fat with magnetic resonance imaging and spectroscopy. J Magn Reson Imaging. 34(4):729-49, 2011
                                                                              10. Boll DT et al: Diffuse liver disease: strategies for hepatic CT and MR imaging. Radiographics. 29(6):1591-614, 2009
                                                                              11. Bahl M et al: Liver steatosis: investigation of opposed-phase T1-weighted liver MR signal intensity loss and visceral fat measurement as biomarkers. Radiology. 249(1):160-6, 2008
                                                                              12. Hamer OW et al: Imaging features of perivascular fatty infiltration of the liver: initial observations. Radiology. 237(1):159-69, 2005