ABPA: Chronic airway inflammation and injury in patients with hypersensitivity to Aspergillus antigens
Allergic response to inhaled Aspergillus spores
Typically affects patients with asthma and cystic fibrosis
Allergic bronchopulmonary mycoses: Chronic airway inflammation/injury due to hypersensitivity to other fungi
Serological ABPA (ABPA-S): Mild form of disease with positive serology and other criteria, but without bronchiectasis
IMAGING
General Features
Radiographic Findings
CT Findings
Imaging Recommendations
MR Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Microscopic Features
CLINICAL ISSUES
Presentation
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
Agarwal R et al: Allergic bronchopulmonary aspergillosis. Indian J Med Res. 151(6):529-49, 2020
Asano K et al: New clinical diagnostic criteria for allergic bronchopulmonary aspergillosis/mycosis and its validation. J Allergy Clin Immunol. 147(4):1261-8.e5, 2020
Lu HW et al: The clinical characteristics and prognosis of ABPA are closely related to the mucus plugs in central bronchiectasis. Clin Respir J. 14(2):140-7, 2020
Russo A et al: Pulmonary aspergillosis: an evolving challenge for diagnosis and treatment. Infect Dis Ther. 9(3):511-24, 2020
Latgé JP et al: Aspergillus fumigatus and Aspergillosis in 2019. Clin Microbiol Rev. 33(1), 2019
Dournes G et al: Allergic bronchopulmonary aspergillosis in cystic fibrosis: MR imaging of airway mucus contrasts as a tool for diagnosis. Radiology. 285(1):261-9, 2017
Phuyal S et al: High-attenuation mucus impaction in patients with allergic bronchopulmonary aspergillosis: objective criteria on high-resolution computed tomography and correlation with serologic parameters. Curr Probl Diagn Radiol. 45(3):168-73, 2016
Shah A et al: Allergic bronchopulmonary aspergillosis: a perplexing clinical entity. Allergy Asthma Immunol Res. 8(4):282-97, 2016
Chabi ML et al: Pulmonary aspergillosis. Diagn Interv Imaging. 96(5):435-42, 2015
Kaur M et al: Allergic bronchopulmonary Aspergillosis (ABPA)-the high resolution computed tomography (HRCT) chest imaging scenario. J Clin Diagn Res. 8(6):RC05-7, 2014
Agarwal R et al: Allergic bronchopulmonary aspergillosis: review of literature and proposal of new diagnostic and classification criteria. Clin Exp Allergy. 43(8):850-73, 2013
Greenberger PA: When to suspect and work up allergic bronchopulmonary aspergillosis. Ann Allergy Asthma Immunol. 111(1):1-4, 2013
Agarwal R et al: Chest radiographic and computed tomographic manifestations in allergic bronchopulmonary aspergillosis. World J Radiol. 4(4):141-50, 2012
Bains SN et al: Allergic bronchopulmonary aspergillosis. Clin Chest Med. 33(2):265-81, 2012
Agarwal R et al: Pictorial essay: allergic bronchopulmonary aspergillosis. Indian J Radiol Imaging. 21(4):242-52, 2011
Greene R: The radiological spectrum of pulmonary aspergillosis. Med Mycol. 43 Suppl 1:S147-54, 2005
Moss RB: Pathophysiology and immunology of allergic bronchopulmonary aspergillosis. Med Mycol. 43 Suppl 1:S203-6, 2005
Franquet T et al: Aspergillus infection of the airways: computed tomography and pathologic findings. J Comput Assist Tomogr. 28(1):10-6, 2004
Khan AN et al: Bronchopulmonary aspergillosis: a review. Curr Probl Diagn Radiol. 32(4):156-68, 2003
Gotway MB et al: The radiologic spectrum of pulmonary Aspergillus infections. J Comput Assist Tomogr. 26(2):159-73, 2002
Related Anatomy
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
Allergic bronchopulmonary aspergillosis (ABPA)
Definitions
ABPA: Chronic airway inflammation and injury in patients with hypersensitivity to Aspergillus antigens
Allergic response to inhaled Aspergillus spores
Typically affects patients with asthma and cystic fibrosis
Allergic bronchopulmonary mycoses: Chronic airway inflammation/injury due to hypersensitivity to other fungi
Serological ABPA (ABPA-S): Mild form of disease with positive serology and other criteria, but without bronchiectasis
IMAGING
General Features
Radiographic Findings
CT Findings
Imaging Recommendations
MR Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Microscopic Features
CLINICAL ISSUES
Presentation
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
Agarwal R et al: Allergic bronchopulmonary aspergillosis. Indian J Med Res. 151(6):529-49, 2020
Asano K et al: New clinical diagnostic criteria for allergic bronchopulmonary aspergillosis/mycosis and its validation. J Allergy Clin Immunol. 147(4):1261-8.e5, 2020
Lu HW et al: The clinical characteristics and prognosis of ABPA are closely related to the mucus plugs in central bronchiectasis. Clin Respir J. 14(2):140-7, 2020
Russo A et al: Pulmonary aspergillosis: an evolving challenge for diagnosis and treatment. Infect Dis Ther. 9(3):511-24, 2020
Latgé JP et al: Aspergillus fumigatus and Aspergillosis in 2019. Clin Microbiol Rev. 33(1), 2019
Dournes G et al: Allergic bronchopulmonary aspergillosis in cystic fibrosis: MR imaging of airway mucus contrasts as a tool for diagnosis. Radiology. 285(1):261-9, 2017
Phuyal S et al: High-attenuation mucus impaction in patients with allergic bronchopulmonary aspergillosis: objective criteria on high-resolution computed tomography and correlation with serologic parameters. Curr Probl Diagn Radiol. 45(3):168-73, 2016
Shah A et al: Allergic bronchopulmonary aspergillosis: a perplexing clinical entity. Allergy Asthma Immunol Res. 8(4):282-97, 2016
Chabi ML et al: Pulmonary aspergillosis. Diagn Interv Imaging. 96(5):435-42, 2015
Kaur M et al: Allergic bronchopulmonary Aspergillosis (ABPA)-the high resolution computed tomography (HRCT) chest imaging scenario. J Clin Diagn Res. 8(6):RC05-7, 2014
Agarwal R et al: Allergic bronchopulmonary aspergillosis: review of literature and proposal of new diagnostic and classification criteria. Clin Exp Allergy. 43(8):850-73, 2013
Greenberger PA: When to suspect and work up allergic bronchopulmonary aspergillosis. Ann Allergy Asthma Immunol. 111(1):1-4, 2013
Agarwal R et al: Chest radiographic and computed tomographic manifestations in allergic bronchopulmonary aspergillosis. World J Radiol. 4(4):141-50, 2012
Bains SN et al: Allergic bronchopulmonary aspergillosis. Clin Chest Med. 33(2):265-81, 2012
Agarwal R et al: Pictorial essay: allergic bronchopulmonary aspergillosis. Indian J Radiol Imaging. 21(4):242-52, 2011
Greene R: The radiological spectrum of pulmonary aspergillosis. Med Mycol. 43 Suppl 1:S147-54, 2005
Moss RB: Pathophysiology and immunology of allergic bronchopulmonary aspergillosis. Med Mycol. 43 Suppl 1:S203-6, 2005
Franquet T et al: Aspergillus infection of the airways: computed tomography and pathologic findings. J Comput Assist Tomogr. 28(1):10-6, 2004
Khan AN et al: Bronchopulmonary aspergillosis: a review. Curr Probl Diagn Radiol. 32(4):156-68, 2003
Gotway MB et al: The radiologic spectrum of pulmonary Aspergillus infections. J Comput Assist Tomogr. 26(2):159-73, 2002
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