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Allergic Bronchopulmonary Aspergillosis
Melissa L. Rosado-de-Christenson, MD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Allergic bronchopulmonary aspergillosis (ABPA)
              • Definitions

                • ABPA: Chronic airway inflammation and injury in patients with hypersensitivity to Aspergillus antigens
                  • Allergic response to inhaled Aspergillus spores
                  • Typically affects patients with asthma and cystic fibrosis
                • Allergic bronchopulmonary mycoses: Chronic airway inflammation/injury due to hypersensitivity to other fungi
                • Serological ABPA (ABPA-S): Mild form of disease with positive serology and other criteria, but without bronchiectasis

              IMAGING

              • General Features

                • Radiographic Findings

                  • CT Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Staging, Grading, & Classification

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Consider

                                      Selected References

                                      1. Phuyal S et al: High-attenuation mucus impaction in patients with allergic bronchopulmonary aspergillosis: objective criteria on high-resolution computed tomography and correlation with serologic parameters. Curr Probl Diagn Radiol. 45(3):168-73, 2016
                                      2. Shah A et al: Allergic bronchopulmonary aspergillosis: a perplexing clinical entity. Allergy Asthma Immunol Res. 8(4):282-97, 2016
                                      3. Chabi ML et al: Pulmonary aspergillosis. Diagn Interv Imaging. 96(5):435-42, 2015
                                      4. Greenberger PA: When to suspect and work up allergic bronchopulmonary aspergillosis. Ann Allergy Asthma Immunol. 111(1):1-4, 2013
                                      5. Bains SN et al: Allergic bronchopulmonary aspergillosis. Clin Chest Med. 33(2):265-81, 2012
                                      6. Greene R: The radiological spectrum of pulmonary aspergillosis. Med Mycol. 43 Suppl 1:S147-54, 2005
                                      7. Moss RB: Pathophysiology and immunology of allergic bronchopulmonary aspergillosis. Med Mycol. 43 Suppl 1:S203-6, 2005
                                      8. Franquet T et al: Aspergillus infection of the airways: computed tomography and pathologic findings. J Comput Assist Tomogr. 28(1):10-6, 2004
                                      9. Khan AN et al: Bronchopulmonary aspergillosis: a review. Curr Probl Diagn Radiol. 32(4):156-68, 2003
                                      10. Gotway MB et al: The radiologic spectrum of pulmonary Aspergillus infections. J Comput Assist Tomogr. 26(2):159-73, 2002
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Top Differential Diagnoses

                                            • Pathology

                                              • Clinical Issues

                                                • Diagnostic Checklist

                                                  TERMINOLOGY

                                                  • Abbreviations

                                                    • Allergic bronchopulmonary aspergillosis (ABPA)
                                                  • Definitions

                                                    • ABPA: Chronic airway inflammation and injury in patients with hypersensitivity to Aspergillus antigens
                                                      • Allergic response to inhaled Aspergillus spores
                                                      • Typically affects patients with asthma and cystic fibrosis
                                                    • Allergic bronchopulmonary mycoses: Chronic airway inflammation/injury due to hypersensitivity to other fungi
                                                    • Serological ABPA (ABPA-S): Mild form of disease with positive serology and other criteria, but without bronchiectasis

                                                  IMAGING

                                                  • General Features

                                                    • Radiographic Findings

                                                      • CT Findings

                                                        • Imaging Recommendations

                                                          DIFFERENTIAL DIAGNOSIS

                                                            PATHOLOGY

                                                            • General Features

                                                              • Staging, Grading, & Classification

                                                                • Microscopic Features

                                                                  CLINICAL ISSUES

                                                                  • Presentation

                                                                    • Natural History & Prognosis

                                                                      • Treatment

                                                                        DIAGNOSTIC CHECKLIST

                                                                        • Consider

                                                                          Selected References

                                                                          1. Phuyal S et al: High-attenuation mucus impaction in patients with allergic bronchopulmonary aspergillosis: objective criteria on high-resolution computed tomography and correlation with serologic parameters. Curr Probl Diagn Radiol. 45(3):168-73, 2016
                                                                          2. Shah A et al: Allergic bronchopulmonary aspergillosis: a perplexing clinical entity. Allergy Asthma Immunol Res. 8(4):282-97, 2016
                                                                          3. Chabi ML et al: Pulmonary aspergillosis. Diagn Interv Imaging. 96(5):435-42, 2015
                                                                          4. Greenberger PA: When to suspect and work up allergic bronchopulmonary aspergillosis. Ann Allergy Asthma Immunol. 111(1):1-4, 2013
                                                                          5. Bains SN et al: Allergic bronchopulmonary aspergillosis. Clin Chest Med. 33(2):265-81, 2012
                                                                          6. Greene R: The radiological spectrum of pulmonary aspergillosis. Med Mycol. 43 Suppl 1:S147-54, 2005
                                                                          7. Moss RB: Pathophysiology and immunology of allergic bronchopulmonary aspergillosis. Med Mycol. 43 Suppl 1:S203-6, 2005
                                                                          8. Franquet T et al: Aspergillus infection of the airways: computed tomography and pathologic findings. J Comput Assist Tomogr. 28(1):10-6, 2004
                                                                          9. Khan AN et al: Bronchopulmonary aspergillosis: a review. Curr Probl Diagn Radiol. 32(4):156-68, 2003
                                                                          10. Gotway MB et al: The radiologic spectrum of pulmonary Aspergillus infections. J Comput Assist Tomogr. 26(2):159-73, 2002