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Amiodarone Toxicity
Jeffrey P. Kanne, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Synonyms

                • Amiodarone-induced lung disease
                • Amiodarone drug reaction
              • Definitions

                • Amiodarone = iodinated benzofuran derivative used to treat various cardiac arrhythmias
                • Lung injury by amiodarone & its metabolites either from direct cytotoxic effect or immunologic reaction
                  • Concentration in the lung; long half-life

              IMAGING

              • General Features

                • Radiographic Findings

                  • CT Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Microscopic Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Consider

                                      • Image Interpretation Pearls

                                        Selected References

                                        1. Wolkove N et al: Amiodarone pulmonary toxicity. Can Respir J. 16(2):43-8, 2009
                                        2. Camus P et al: Amiodarone pulmonary toxicity. Clin Chest Med. 25(1):65-75, 2004
                                        3. Aronchick JM et al: Drug-induced pulmonary disorders. Semin Roentgenol. 30(1):18-34, 1995
                                        4. Kuhlman JE et al: Amiodarone pulmonary toxicity: CT findings in symptomatic patients. Radiology. 177(1):121-5, 1990
                                        5. Myers JL et al: Amiodarone lung: pathologic findings in clinically toxic patients. Hum Pathol. 18(4):349-54, 1987
                                        Related Anatomy
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                                        Related Differential Diagnoses
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Terminology

                                          • Imaging

                                            • Top Differential Diagnoses

                                              • Pathology

                                                • Clinical Issues

                                                  • Diagnostic Checklist

                                                    TERMINOLOGY

                                                    • Synonyms

                                                      • Amiodarone-induced lung disease
                                                      • Amiodarone drug reaction
                                                    • Definitions

                                                      • Amiodarone = iodinated benzofuran derivative used to treat various cardiac arrhythmias
                                                      • Lung injury by amiodarone & its metabolites either from direct cytotoxic effect or immunologic reaction
                                                        • Concentration in the lung; long half-life

                                                    IMAGING

                                                    • General Features

                                                      • Radiographic Findings

                                                        • CT Findings

                                                          • Imaging Recommendations

                                                            DIFFERENTIAL DIAGNOSIS

                                                              PATHOLOGY

                                                              • General Features

                                                                • Microscopic Features

                                                                  CLINICAL ISSUES

                                                                  • Presentation

                                                                    • Demographics

                                                                      • Natural History & Prognosis

                                                                        • Treatment

                                                                          DIAGNOSTIC CHECKLIST

                                                                          • Consider

                                                                            • Image Interpretation Pearls

                                                                              Selected References

                                                                              1. Wolkove N et al: Amiodarone pulmonary toxicity. Can Respir J. 16(2):43-8, 2009
                                                                              2. Camus P et al: Amiodarone pulmonary toxicity. Clin Chest Med. 25(1):65-75, 2004
                                                                              3. Aronchick JM et al: Drug-induced pulmonary disorders. Semin Roentgenol. 30(1):18-34, 1995
                                                                              4. Kuhlman JE et al: Amiodarone pulmonary toxicity: CT findings in symptomatic patients. Radiology. 177(1):121-5, 1990
                                                                              5. Myers JL et al: Amiodarone lung: pathologic findings in clinically toxic patients. Hum Pathol. 18(4):349-54, 1987