link
Bookmarks
Amorphous Calcifications
Wendie A. Berg, MD, PhD, FACR, FSBI
To access 4,300 diagnoses written by the world's leading experts in radiology, please log in or subscribe.Log inSubscribe
0
26
1
0

KEY FACTS

  • Terminology

    • Imaging

      • Diagnostic Checklist

        TERMINOLOGY

        • Synonyms

          • Indistinct calcifications (Ca⁺⁺)
        • Definitions

          • Indistinct, powdery Ca⁺⁺ so small that more specific morphologic classification cannot be assigned

        IMAGING

        • General Features

          • Mammographic Findings

            • Ultrasonographic Findings

              • MR Findings

                • Image-Guided Biopsy

                  • Imaging Recommendations

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Microscopic Features

                          CLINICAL ISSUES

                          • Presentation

                            • Management

                              DIAGNOSTIC CHECKLIST

                              • Consider

                                • Image Interpretation Pearls

                                  Selected References

                                  1. Oligane HC et al: Grouped amorphous calcifications on mammography: Frequently atypical but rarely associated with invasive malignancy. Radiology. 288(3):671-679, 2018
                                  2. Iwase M et al: Overcalling low-risk findings: grouped amorphous calcifications found at screening mammography associated with minimal cancer risk. Breast Cancer. 24(4):579-584, 2017
                                  3. Rudin AV et al: Flat epithelial atypia on core biopsy and upgrade to cancer: a systematic review and meta-analysis. Ann Surg Oncol. 24(12):3549-3558, 2017
                                  4. Nelson JS et al: How does c-view image quality compare with conventional 2D FFDM? Med Phys. 43(5):2538, 2016
                                  5. Chang Sen LQ et al: Core breast biopsies showing lobular carcinoma in situ should be excised and surveillance Is reasonable for atypical lobular hyperplasia. AJR Am J Roentgenol. 207(5):1132-1145, 2016
                                  6. Youn I et al: Absence of residual microcalcifications in atypical ductal hyperplasia diagnosed via stereotactic vacuum-assisted breast biopsy: Is surgical excision obviated? J Breast Cancer. 17(3):265-9, 2014
                                  7. Becker AK et al: Flat ductal intraepithelial neoplasia 1A diagnosed at stereotactic core needle biopsy: is excisional biopsy indicated? AJR Am J Roentgenol. 200(3):682-8, 2013
                                  8. Sickles EA et al: Breast Imaging Reporting and Data System: BI-RADS, Mammography. 5th ed. Reston: American College of Radiology, 2013
                                  9. Scaranelo AM et al: Evaluation of breast amorphous calcifications by a computer-aided detection system in full-field digital mammography. Br J Radiol. 85(1013):517-22, 2012
                                  10. Lavoué V et al: Pure flat epithelial atypia (DIN 1a) on core needle biopsy: study of 60 biopsies with follow-up surgical excision. Breast Cancer Res Treat. 125(1):121-6, 2011
                                  11. Bent CK et al: The positive predictive value of BI-RADS microcalcification descriptors and final assessment categories. AJR Am J Roentgenol. 194(5):1378-83, 2010
                                  12. Burnside ES et al: Use of microcalcification descriptors in BI-RADS 4th edition to stratify risk of malignancy. Radiology. 242(2):388-95, 2007
                                  13. Soo MS et al: Computer-aided detection of amorphous calcifications. AJR Am J Roentgenol. 184(3):887-92, 2005
                                  14. Jackman RJ et al: Atypical ductal hyperplasia: can some lesions be defined as probably benign after stereotactic 11-gauge vacuum-assisted biopsy, eliminating the recommendation for surgical excision? Radiology. 224(2):548-54, 2002
                                  15. Berg WA et al: Atypical lobular hyperplasia or lobular carcinoma in situ at core-needle breast biopsy. Radiology. 218(2):503-9, 2001
                                  16. Berg WA et al: Biopsy of amorphous breast calcifications: pathologic outcome and yield at stereotactic biopsy. Radiology. 221(2):495-503, 2001
                                  17. Jackman RJ et al: Stereotactic breast biopsy of nonpalpable lesions: determinants of ductal carcinoma in situ underestimation rates. Radiology. 218(2):497-502, 2001
                                  18. Darling ML et al: Atypical ductal hyperplasia and ductal carcinoma in situ as revealed by large-core needle breast biopsy: results of surgical excision. AJR Am J Roentgenol. 175(5):1341-6, 2000
                                  19. Brem RF et al: Atypical ductal hyperplasia: histologic underestimation of carcinoma in tissue harvested from impalpable breast lesions using 11-gauge stereotactically guided directional vacuum-assisted biopsy. AJR Am J Roentgenol. 172(5):1405-7, 1999
                                  20. Liberman L et al: The breast imaging reporting and data system: positive predictive value of mammographic features and final assessment categories. AJR Am J Roentgenol. 171(1):35-40, 1998
                                  21. Pisano ED et al: Rate of insufficient samples for fine-needle aspiration for nonpalpable breast lesions in a multicenter clinical trial: The Radiologic Diagnostic Oncology Group 5 Study. The RDOG5 investigators. Cancer. 82(4):679-88, 1998
                                  22. Selim A et al: Microscopic localization of calcifications in and around breast carcinoma: a cautionary note for needle core biopsies. Ann Surg. 228(1):95-8, 1998
                                  23. Burbank F: Stereotactic breast biopsy of atypical ductal hyperplasia and ductal carcinoma in situ lesions: improved accuracy with directional, vacuum-assisted biopsy. Radiology. 202(3):843-7, 1997
                                  24. Jackman RJ et al: Atypical ductal hyperplasia diagnosed at stereotactic breast biopsy: improved reliability with 14-gauge, directional, vacuum-assisted biopsy. Radiology. 204(2):485-8, 1997
                                  25. Berg WA: When is core breast biopsy or fine-needle aspiration not enough? Radiology. 198(2):313-5, 1996
                                  26. Lev-Toaff AS et al: Stability of malignant breast microcalcifications. Radiology. 192(1):153-6, 1994
                                  27. D'Orsi CJ et al: Mammographic feature analysis. Semin Roentgenol. 28(3):204-30, 1993
                                  28. Stomper PC et al: Atypical hyperplasia: frequency and mammographic and pathologic relationships in excisional biopsies guided with mammography and clinical examination. Radiology. 189(3):667-71, 1993
                                  29. Truong LD et al: Calcium oxalate in breast lesions biopsied for calcification detected in screening mammography: incidence and clinical significance. Mod Pathol. 5(2):146-52, 1992
                                  30. Tornos C et al: Calcium oxalate crystals in breast biopsies. The missing microcalcifications. Am J Surg Pathol. 14(10):961-8, 1990
                                  31. Homer MJ et al: The relationship of mammographic microcalcification to histologic malignancy: radiologic-pathologic correlation. AJR Am J Roentgenol. 153(6):1187-9, 1989
                                  32. Colbassani HJ Jr et al: Mammographic and pathologic correlation of microcalcification in disease of the breast. Surg Gynecol Obstet. 155(5):689-96, 1982
                                  Related Anatomy
                                  Loading...
                                  Related Differential Diagnoses
                                  Loading...
                                  References
                                  Tables

                                  Tables

                                  KEY FACTS

                                  • Terminology

                                    • Imaging

                                      • Diagnostic Checklist

                                        TERMINOLOGY

                                        • Synonyms

                                          • Indistinct calcifications (Ca⁺⁺)
                                        • Definitions

                                          • Indistinct, powdery Ca⁺⁺ so small that more specific morphologic classification cannot be assigned

                                        IMAGING

                                        • General Features

                                          • Mammographic Findings

                                            • Ultrasonographic Findings

                                              • MR Findings

                                                • Image-Guided Biopsy

                                                  • Imaging Recommendations

                                                    DIFFERENTIAL DIAGNOSIS

                                                      PATHOLOGY

                                                      • General Features

                                                        • Microscopic Features

                                                          CLINICAL ISSUES

                                                          • Presentation

                                                            • Management

                                                              DIAGNOSTIC CHECKLIST

                                                              • Consider

                                                                • Image Interpretation Pearls

                                                                  Selected References

                                                                  1. Oligane HC et al: Grouped amorphous calcifications on mammography: Frequently atypical but rarely associated with invasive malignancy. Radiology. 288(3):671-679, 2018
                                                                  2. Iwase M et al: Overcalling low-risk findings: grouped amorphous calcifications found at screening mammography associated with minimal cancer risk. Breast Cancer. 24(4):579-584, 2017
                                                                  3. Rudin AV et al: Flat epithelial atypia on core biopsy and upgrade to cancer: a systematic review and meta-analysis. Ann Surg Oncol. 24(12):3549-3558, 2017
                                                                  4. Nelson JS et al: How does c-view image quality compare with conventional 2D FFDM? Med Phys. 43(5):2538, 2016
                                                                  5. Chang Sen LQ et al: Core breast biopsies showing lobular carcinoma in situ should be excised and surveillance Is reasonable for atypical lobular hyperplasia. AJR Am J Roentgenol. 207(5):1132-1145, 2016
                                                                  6. Youn I et al: Absence of residual microcalcifications in atypical ductal hyperplasia diagnosed via stereotactic vacuum-assisted breast biopsy: Is surgical excision obviated? J Breast Cancer. 17(3):265-9, 2014
                                                                  7. Becker AK et al: Flat ductal intraepithelial neoplasia 1A diagnosed at stereotactic core needle biopsy: is excisional biopsy indicated? AJR Am J Roentgenol. 200(3):682-8, 2013
                                                                  8. Sickles EA et al: Breast Imaging Reporting and Data System: BI-RADS, Mammography. 5th ed. Reston: American College of Radiology, 2013
                                                                  9. Scaranelo AM et al: Evaluation of breast amorphous calcifications by a computer-aided detection system in full-field digital mammography. Br J Radiol. 85(1013):517-22, 2012
                                                                  10. Lavoué V et al: Pure flat epithelial atypia (DIN 1a) on core needle biopsy: study of 60 biopsies with follow-up surgical excision. Breast Cancer Res Treat. 125(1):121-6, 2011
                                                                  11. Bent CK et al: The positive predictive value of BI-RADS microcalcification descriptors and final assessment categories. AJR Am J Roentgenol. 194(5):1378-83, 2010
                                                                  12. Burnside ES et al: Use of microcalcification descriptors in BI-RADS 4th edition to stratify risk of malignancy. Radiology. 242(2):388-95, 2007
                                                                  13. Soo MS et al: Computer-aided detection of amorphous calcifications. AJR Am J Roentgenol. 184(3):887-92, 2005
                                                                  14. Jackman RJ et al: Atypical ductal hyperplasia: can some lesions be defined as probably benign after stereotactic 11-gauge vacuum-assisted biopsy, eliminating the recommendation for surgical excision? Radiology. 224(2):548-54, 2002
                                                                  15. Berg WA et al: Atypical lobular hyperplasia or lobular carcinoma in situ at core-needle breast biopsy. Radiology. 218(2):503-9, 2001
                                                                  16. Berg WA et al: Biopsy of amorphous breast calcifications: pathologic outcome and yield at stereotactic biopsy. Radiology. 221(2):495-503, 2001
                                                                  17. Jackman RJ et al: Stereotactic breast biopsy of nonpalpable lesions: determinants of ductal carcinoma in situ underestimation rates. Radiology. 218(2):497-502, 2001
                                                                  18. Darling ML et al: Atypical ductal hyperplasia and ductal carcinoma in situ as revealed by large-core needle breast biopsy: results of surgical excision. AJR Am J Roentgenol. 175(5):1341-6, 2000
                                                                  19. Brem RF et al: Atypical ductal hyperplasia: histologic underestimation of carcinoma in tissue harvested from impalpable breast lesions using 11-gauge stereotactically guided directional vacuum-assisted biopsy. AJR Am J Roentgenol. 172(5):1405-7, 1999
                                                                  20. Liberman L et al: The breast imaging reporting and data system: positive predictive value of mammographic features and final assessment categories. AJR Am J Roentgenol. 171(1):35-40, 1998
                                                                  21. Pisano ED et al: Rate of insufficient samples for fine-needle aspiration for nonpalpable breast lesions in a multicenter clinical trial: The Radiologic Diagnostic Oncology Group 5 Study. The RDOG5 investigators. Cancer. 82(4):679-88, 1998
                                                                  22. Selim A et al: Microscopic localization of calcifications in and around breast carcinoma: a cautionary note for needle core biopsies. Ann Surg. 228(1):95-8, 1998
                                                                  23. Burbank F: Stereotactic breast biopsy of atypical ductal hyperplasia and ductal carcinoma in situ lesions: improved accuracy with directional, vacuum-assisted biopsy. Radiology. 202(3):843-7, 1997
                                                                  24. Jackman RJ et al: Atypical ductal hyperplasia diagnosed at stereotactic breast biopsy: improved reliability with 14-gauge, directional, vacuum-assisted biopsy. Radiology. 204(2):485-8, 1997
                                                                  25. Berg WA: When is core breast biopsy or fine-needle aspiration not enough? Radiology. 198(2):313-5, 1996
                                                                  26. Lev-Toaff AS et al: Stability of malignant breast microcalcifications. Radiology. 192(1):153-6, 1994
                                                                  27. D'Orsi CJ et al: Mammographic feature analysis. Semin Roentgenol. 28(3):204-30, 1993
                                                                  28. Stomper PC et al: Atypical hyperplasia: frequency and mammographic and pathologic relationships in excisional biopsies guided with mammography and clinical examination. Radiology. 189(3):667-71, 1993
                                                                  29. Truong LD et al: Calcium oxalate in breast lesions biopsied for calcification detected in screening mammography: incidence and clinical significance. Mod Pathol. 5(2):146-52, 1992
                                                                  30. Tornos C et al: Calcium oxalate crystals in breast biopsies. The missing microcalcifications. Am J Surg Pathol. 14(10):961-8, 1990
                                                                  31. Homer MJ et al: The relationship of mammographic microcalcification to histologic malignancy: radiologic-pathologic correlation. AJR Am J Roentgenol. 153(6):1187-9, 1989
                                                                  32. Colbassani HJ Jr et al: Mammographic and pathologic correlation of microcalcification in disease of the breast. Surg Gynecol Obstet. 155(5):689-96, 1982