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Amyloid Deposition
B.J. Manaster, MD, PhD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Pathology

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Definitions

              • Multisystem disorder caused by deposition of fibrillar protein aggregates
                • Interfere with structural integrity and function of involved organs and tissues
              • 4 main types, distinguished by deposited proteins and clinical associations

            IMAGING

            • General Features

              • Imaging Recommendations

                • Radiographic Findings

                  • MR Findings

                    • Ultrasonographic Findings

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Microscopic Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    DIAGNOSTIC CHECKLIST

                                    • Consider

                                      Selected References

                                      1. Loizos S et al: Amyloidosis: review and imaging findings. Semin Ultrasound CT MR. 35(3):225-39, 2014
                                      2. Beggs SA et al: A chronic thigh mass in a 69-year-old man. Amyloidoma presenting as a chronic soft tissue mass. Skeletal Radiol. 39(12):1237, 1259-61, 2010
                                      3. Maheshwari AV et al: Soft-tissue amyloidoma of the extremities: a case report and review of literature. Skeletal Radiol. 38(3):287-92, 2009
                                      4. Agarwal V et al: A clinical, electrophysiological, and pathological study of neuropathy in rheumatoid arthritis. Clin Rheumatol. 27(7):841-4, 2008
                                      5. Katoh N et al: Systemic AL amyloidosis mimicking rheumatoid arthritis. Intern Med. 47(12):1133-8, 2008
                                      6. Koivuniemi R et al: Amyloidosis is frequently undetected in patients with rheumatoid arthritis. Amyloid. 15(4):262-8, 2008
                                      7. Kuroda T et al: A case of AA amyloidosis associated with rheumatoid arthritis effectively treated with Infliximab. Rheumatol Int. 28(11):1155-9, 2008
                                      8. Nakamura T: Clinical strategies for amyloid A amyloidosis secondary to rheumatoid arthritis. Mod Rheumatol. 18(2):109-18, 2008
                                      9. Nishi S et al: New advances in renal amyloidosis. Clin Exp Nephrol. 12(2):93-101, 2008
                                      10. Perry ME et al: Effect of etanercept on serum amyloid A protein (SAA) levels in patients with AA amyloidosis complicating inflammatory arthritis. Clin Rheumatol. 27(7):923-5, 2008
                                      11. Mavragani CP et al: Analysis of SAA1 gene polymorphisms in the Greek population: rheumatoid arthritis and FMF patients relative to normal controls. Homogeneous distribution and low incidence of AA amyloidosis. Amyloid. 14(4):271-5, 2007
                                      12. Kiss E et al: Dialysis-related amyloidosis revisited. AJR Am J Roentgenol. 185(6):1460-7, 2005
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Pathology

                                            • Clinical Issues

                                              • Diagnostic Checklist

                                                TERMINOLOGY

                                                • Definitions

                                                  • Multisystem disorder caused by deposition of fibrillar protein aggregates
                                                    • Interfere with structural integrity and function of involved organs and tissues
                                                  • 4 main types, distinguished by deposited proteins and clinical associations

                                                IMAGING

                                                • General Features

                                                  • Imaging Recommendations

                                                    • Radiographic Findings

                                                      • MR Findings

                                                        • Ultrasonographic Findings

                                                          DIFFERENTIAL DIAGNOSIS

                                                            PATHOLOGY

                                                            • General Features

                                                              • Microscopic Features

                                                                CLINICAL ISSUES

                                                                • Presentation

                                                                  • Demographics

                                                                    • Natural History & Prognosis

                                                                      • Treatment

                                                                        DIAGNOSTIC CHECKLIST

                                                                        • Consider

                                                                          Selected References

                                                                          1. Loizos S et al: Amyloidosis: review and imaging findings. Semin Ultrasound CT MR. 35(3):225-39, 2014
                                                                          2. Beggs SA et al: A chronic thigh mass in a 69-year-old man. Amyloidoma presenting as a chronic soft tissue mass. Skeletal Radiol. 39(12):1237, 1259-61, 2010
                                                                          3. Maheshwari AV et al: Soft-tissue amyloidoma of the extremities: a case report and review of literature. Skeletal Radiol. 38(3):287-92, 2009
                                                                          4. Agarwal V et al: A clinical, electrophysiological, and pathological study of neuropathy in rheumatoid arthritis. Clin Rheumatol. 27(7):841-4, 2008
                                                                          5. Katoh N et al: Systemic AL amyloidosis mimicking rheumatoid arthritis. Intern Med. 47(12):1133-8, 2008
                                                                          6. Koivuniemi R et al: Amyloidosis is frequently undetected in patients with rheumatoid arthritis. Amyloid. 15(4):262-8, 2008
                                                                          7. Kuroda T et al: A case of AA amyloidosis associated with rheumatoid arthritis effectively treated with Infliximab. Rheumatol Int. 28(11):1155-9, 2008
                                                                          8. Nakamura T: Clinical strategies for amyloid A amyloidosis secondary to rheumatoid arthritis. Mod Rheumatol. 18(2):109-18, 2008
                                                                          9. Nishi S et al: New advances in renal amyloidosis. Clin Exp Nephrol. 12(2):93-101, 2008
                                                                          10. Perry ME et al: Effect of etanercept on serum amyloid A protein (SAA) levels in patients with AA amyloidosis complicating inflammatory arthritis. Clin Rheumatol. 27(7):923-5, 2008
                                                                          11. Mavragani CP et al: Analysis of SAA1 gene polymorphisms in the Greek population: rheumatoid arthritis and FMF patients relative to normal controls. Homogeneous distribution and low incidence of AA amyloidosis. Amyloid. 14(4):271-5, 2007
                                                                          12. Kiss E et al: Dialysis-related amyloidosis revisited. AJR Am J Roentgenol. 185(6):1460-7, 2005