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Amyloid Deposition
Eva M. Escobedo, MD; Dylan A. Noblett, MD; B. J. Manaster, MD, PhD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Pathology

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Definitions

              • Multisystem disorder caused by deposition of fibrillar protein aggregates
                • Interfere with structural integrity and function of involved organs and tissues
              • 4 main types, distinguished by deposited proteins and clinical associations

            IMAGING

            • General Features

              • Imaging Recommendations

                • Radiographic Findings

                  • MR Findings

                    • Ultrasonographic Findings

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        Selected References

                                        1. Civriz AH et al: Giant exophytic tumor of the leg: a case report of amyloidoma with literature review. Indian J Pathol Microbiol. 64(4):810-3, 2021
                                        2. Dhatt R et al: Localized plantar amyloidosis: case report and review of the literature. Skeletal Radiol. 50(7):1467-72, 2021
                                        3. Diaz-Perez JA et al: Amyloid arthropathy: a review. Adv Anat Pathol. 28(6):415-25, 2021
                                        4. Kanda E et al: Beta-2 microglobulin and all-cause mortality in the era of high-flux hemodialysis: results from the Dialysis Outcomes and Practice Patterns Study. Clin Kidney J. 14(5):1436-42, 2021
                                        5. Sigaux J et al: Tendon thickening in dialysis-related joint arthritis is due to amyloid deposits at the surface of the tendon. Joint Bone Spine. 86(2):233-8, 2019
                                        6. Loizos S et al: Amyloidosis: review and imaging findings. Semin Ultrasound CT MR. 35(3):225-39, 2014
                                        7. Beggs SA et al: A chronic thigh mass in a 69-year-old man. Amyloidoma presenting as a chronic soft tissue mass. Skeletal Radiol. 39(12):1237, 1259-61, 2010
                                        8. Maheshwari AV et al: Soft-tissue amyloidoma of the extremities: a case report and review of literature. Skeletal Radiol. 38(3):287-92, 2009
                                        9. Agarwal V et al: A clinical, electrophysiological, and pathological study of neuropathy in rheumatoid arthritis. Clin Rheumatol. 27(7):841-4, 2008
                                        10. Katoh N et al: Systemic AL amyloidosis mimicking rheumatoid arthritis. Intern Med. 47(12):1133-8, 2008
                                        11. Koivuniemi R et al: Amyloidosis is frequently undetected in patients with rheumatoid arthritis. Amyloid. 15(4):262-8, 2008
                                        12. Kuroda T et al: A case of AA amyloidosis associated with rheumatoid arthritis effectively treated with Infliximab. Rheumatol Int. 28(11):1155-9, 2008
                                        13. Nakamura T: Clinical strategies for amyloid A amyloidosis secondary to rheumatoid arthritis. Mod Rheumatol. 18(2):109-18, 2008
                                        14. Nishi S et al: New advances in renal amyloidosis. Clin Exp Nephrol. 12(2):93-101, 2008
                                        15. Perry ME et al: Effect of etanercept on serum amyloid A protein (SAA) levels in patients with AA amyloidosis complicating inflammatory arthritis. Clin Rheumatol. 27(7):923-5, 2008
                                        16. Mavragani CP et al: Analysis of SAA1 gene polymorphisms in the Greek population: rheumatoid arthritis and FMF patients relative to normal controls. Homogeneous distribution and low incidence of AA amyloidosis. Amyloid. 14(4):271-5, 2007
                                        17. Pasternak S et al: Soft tissue amyloidoma of the extremities: report of a case and review of the literature. Am J Dermatopathol. 29(2):152-5, 2007
                                        18. Biewend ML et al: The spectrum of localized amyloidosis: a case series of 20 patients and review of the literature. Amyloid. 13(3):135-42, 2006
                                        19. Kiss E et al: Dialysis-related amyloidosis revisited. AJR Am J Roentgenol. 185(6):1460-7, 2005
                                        20. Krishnan J et al: Tumoral presentation of amyloidosis (amyloidomas) in soft tissues. A report of 14 cases. Am J Clin Pathol. 100(2):135-44, 1993
                                        Related Anatomy
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                                        Related Differential Diagnoses
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Terminology

                                          • Imaging

                                            • Pathology

                                              • Clinical Issues

                                                • Diagnostic Checklist

                                                  TERMINOLOGY

                                                  • Definitions

                                                    • Multisystem disorder caused by deposition of fibrillar protein aggregates
                                                      • Interfere with structural integrity and function of involved organs and tissues
                                                    • 4 main types, distinguished by deposited proteins and clinical associations

                                                  IMAGING

                                                  • General Features

                                                    • Imaging Recommendations

                                                      • Radiographic Findings

                                                        • MR Findings

                                                          • Ultrasonographic Findings

                                                            DIFFERENTIAL DIAGNOSIS

                                                              PATHOLOGY

                                                              • General Features

                                                                • Gross Pathologic & Surgical Features

                                                                  • Microscopic Features

                                                                    CLINICAL ISSUES

                                                                    • Presentation

                                                                      • Demographics

                                                                        • Natural History & Prognosis

                                                                          • Treatment

                                                                            DIAGNOSTIC CHECKLIST

                                                                            • Consider

                                                                              Selected References

                                                                              1. Civriz AH et al: Giant exophytic tumor of the leg: a case report of amyloidoma with literature review. Indian J Pathol Microbiol. 64(4):810-3, 2021
                                                                              2. Dhatt R et al: Localized plantar amyloidosis: case report and review of the literature. Skeletal Radiol. 50(7):1467-72, 2021
                                                                              3. Diaz-Perez JA et al: Amyloid arthropathy: a review. Adv Anat Pathol. 28(6):415-25, 2021
                                                                              4. Kanda E et al: Beta-2 microglobulin and all-cause mortality in the era of high-flux hemodialysis: results from the Dialysis Outcomes and Practice Patterns Study. Clin Kidney J. 14(5):1436-42, 2021
                                                                              5. Sigaux J et al: Tendon thickening in dialysis-related joint arthritis is due to amyloid deposits at the surface of the tendon. Joint Bone Spine. 86(2):233-8, 2019
                                                                              6. Loizos S et al: Amyloidosis: review and imaging findings. Semin Ultrasound CT MR. 35(3):225-39, 2014
                                                                              7. Beggs SA et al: A chronic thigh mass in a 69-year-old man. Amyloidoma presenting as a chronic soft tissue mass. Skeletal Radiol. 39(12):1237, 1259-61, 2010
                                                                              8. Maheshwari AV et al: Soft-tissue amyloidoma of the extremities: a case report and review of literature. Skeletal Radiol. 38(3):287-92, 2009
                                                                              9. Agarwal V et al: A clinical, electrophysiological, and pathological study of neuropathy in rheumatoid arthritis. Clin Rheumatol. 27(7):841-4, 2008
                                                                              10. Katoh N et al: Systemic AL amyloidosis mimicking rheumatoid arthritis. Intern Med. 47(12):1133-8, 2008
                                                                              11. Koivuniemi R et al: Amyloidosis is frequently undetected in patients with rheumatoid arthritis. Amyloid. 15(4):262-8, 2008
                                                                              12. Kuroda T et al: A case of AA amyloidosis associated with rheumatoid arthritis effectively treated with Infliximab. Rheumatol Int. 28(11):1155-9, 2008
                                                                              13. Nakamura T: Clinical strategies for amyloid A amyloidosis secondary to rheumatoid arthritis. Mod Rheumatol. 18(2):109-18, 2008
                                                                              14. Nishi S et al: New advances in renal amyloidosis. Clin Exp Nephrol. 12(2):93-101, 2008
                                                                              15. Perry ME et al: Effect of etanercept on serum amyloid A protein (SAA) levels in patients with AA amyloidosis complicating inflammatory arthritis. Clin Rheumatol. 27(7):923-5, 2008
                                                                              16. Mavragani CP et al: Analysis of SAA1 gene polymorphisms in the Greek population: rheumatoid arthritis and FMF patients relative to normal controls. Homogeneous distribution and low incidence of AA amyloidosis. Amyloid. 14(4):271-5, 2007
                                                                              17. Pasternak S et al: Soft tissue amyloidoma of the extremities: report of a case and review of the literature. Am J Dermatopathol. 29(2):152-5, 2007
                                                                              18. Biewend ML et al: The spectrum of localized amyloidosis: a case series of 20 patients and review of the literature. Amyloid. 13(3):135-42, 2006
                                                                              19. Kiss E et al: Dialysis-related amyloidosis revisited. AJR Am J Roentgenol. 185(6):1460-7, 2005
                                                                              20. Krishnan J et al: Tumoral presentation of amyloidosis (amyloidomas) in soft tissues. A report of 14 cases. Am J Clin Pathol. 100(2):135-44, 1993