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Breast
Special Topics
Breast Manifestations of Systemic Conditions
Amyloid
Amyloid
Wendie A. Berg, MD, PhD, FACR, FSBI; Wei Tse Yang, MBBS
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Definitions

              • Systemic or localized deposition of insoluble proteins
                • Primary amyloidosis of breast without systemic involvement
                • Secondary (systemic) may result in breast involvement later

            IMAGING

            • General Features

              • Mammographic Findings

                • Ultrasonographic Findings

                  • MR Findings

                    • Image-Guided Biopsy

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        Selected References

                                        1. Tsuji W et al: Localized primary amyloidosis of the breast: a case report and review of the literature. BMC Surg. 16(1):62, 2016
                                        2. Eghtedari M et al: Imaging and pathologic characteristics of breast amyloidosis. Breast J. 21(2):197-9, 2015
                                        3. Huerter ME et al: Primary amyloidosis of the breast presenting as a solitary nodule: case report and review of the literature. Ochsner J. 14(2):282-6, 2014
                                        4. O'Brien J et al: MRI features of bilateral amyloidosis of breast. Breast J. 19(3):338-9, 2013
                                        5. Said SM et al: Amyloidosis of the breast: predominantly AL type and over half have concurrent breast hematologic disorders. Mod Pathol. 26(2):232-8, 2013
                                        6. Shim Y et al: Primary breast amyloidosis presenting as microcalcifications only. Korean J Radiol. 14(5):723-6, 2013
                                        7. Charlot M et al: Localized amyloidosis of the breast: a case series. Amyloid. 18(2):72-5, 2011
                                        8. Ayers DE et al: Amyloid tumour of the breast mimicking carcinoma. Cytopathology. 13(4):254-6, 2002
                                        9. Gal-Gombos EC et al: Primary amyloidosis of the breast presenting solely as microcalcifications. AJR Am J Roentgenol. 179(1):274; author reply 274, 2002
                                        10. Gluck BS et al: Amyloid deposition of the breast. AJR Am J Roentgenol. 175(6):1590, 2000
                                        11. Luo JH et al: Primary amyloid tumor of the breast: a case report and review of the literature. Mod Pathol. 10(7):735-8, 1997
                                        12. Symonds DA et al: Calcifying amyloidoma of the breast. South Med J. 88(11):1169-72, 1995
                                        13. Lynch LA et al: Localized primary amyloid tumor associated with osseous metaplasia presenting as bilateral breast masses: cytologic and radiologic features. Diagn Cytopathol. 9(5):570-5, 1993
                                        14. Hecht AH et al: Case report: primary systemic amyloidosis presenting as breast masses, mammographically simulating carcinoma. Clin Radiol. 44(2):123-4, 1991
                                        15. Cheung PS et al: Bilateral amyloid tumours of the breast. Aust N Z J Surg. 56(4):375-7, 1986
                                        16. Silverman JF et al: Localized primary (AL) amyloid tumor of the breast. Cytologic, histologic, immunocytochemical and ultrastructural observations. Am J Surg Pathol. 10(8):539-45, 1986
                                        17. Baranets NA et al: [Prognostic value of determining the succinate dehydrogenase activity of lymphocytes and the therapeutic effectiveness of sodium succinate in resuscitation of rats.] Biull Eksp Biol Med. 100(10):405-7, 1985
                                        18. Hardy TJ et al: Diffuse parenchymal amyloidosis of lungs and breast. Its association with diffuse plasmacytosis and kappa-chain gammopathy. Arch Pathol Lab Med. 103(11):583-5, 1979
                                        19. Fernandez BB et al: Amyloid tumor of the breast. Arch Pathol. 95(2):102-5, 1973
                                        Related Anatomy
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                                        Related Differential Diagnoses
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                                        References
                                        Tables

                                        Tables

                                        KEY FACTS

                                        • Terminology

                                          • Imaging

                                            • Top Differential Diagnoses

                                              • Pathology

                                                • Clinical Issues

                                                  TERMINOLOGY

                                                  • Definitions

                                                    • Systemic or localized deposition of insoluble proteins
                                                      • Primary amyloidosis of breast without systemic involvement
                                                      • Secondary (systemic) may result in breast involvement later

                                                  IMAGING

                                                  • General Features

                                                    • Mammographic Findings

                                                      • Ultrasonographic Findings

                                                        • MR Findings

                                                          • Image-Guided Biopsy

                                                            • Imaging Recommendations

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • General Features

                                                                  • Gross Pathologic & Surgical Features

                                                                    • Microscopic Features

                                                                      CLINICAL ISSUES

                                                                      • Presentation

                                                                        • Demographics

                                                                          • Natural History & Prognosis

                                                                            • Treatment

                                                                              Selected References

                                                                              1. Tsuji W et al: Localized primary amyloidosis of the breast: a case report and review of the literature. BMC Surg. 16(1):62, 2016
                                                                              2. Eghtedari M et al: Imaging and pathologic characteristics of breast amyloidosis. Breast J. 21(2):197-9, 2015
                                                                              3. Huerter ME et al: Primary amyloidosis of the breast presenting as a solitary nodule: case report and review of the literature. Ochsner J. 14(2):282-6, 2014
                                                                              4. O'Brien J et al: MRI features of bilateral amyloidosis of breast. Breast J. 19(3):338-9, 2013
                                                                              5. Said SM et al: Amyloidosis of the breast: predominantly AL type and over half have concurrent breast hematologic disorders. Mod Pathol. 26(2):232-8, 2013
                                                                              6. Shim Y et al: Primary breast amyloidosis presenting as microcalcifications only. Korean J Radiol. 14(5):723-6, 2013
                                                                              7. Charlot M et al: Localized amyloidosis of the breast: a case series. Amyloid. 18(2):72-5, 2011
                                                                              8. Ayers DE et al: Amyloid tumour of the breast mimicking carcinoma. Cytopathology. 13(4):254-6, 2002
                                                                              9. Gal-Gombos EC et al: Primary amyloidosis of the breast presenting solely as microcalcifications. AJR Am J Roentgenol. 179(1):274; author reply 274, 2002
                                                                              10. Gluck BS et al: Amyloid deposition of the breast. AJR Am J Roentgenol. 175(6):1590, 2000
                                                                              11. Luo JH et al: Primary amyloid tumor of the breast: a case report and review of the literature. Mod Pathol. 10(7):735-8, 1997
                                                                              12. Symonds DA et al: Calcifying amyloidoma of the breast. South Med J. 88(11):1169-72, 1995
                                                                              13. Lynch LA et al: Localized primary amyloid tumor associated with osseous metaplasia presenting as bilateral breast masses: cytologic and radiologic features. Diagn Cytopathol. 9(5):570-5, 1993
                                                                              14. Hecht AH et al: Case report: primary systemic amyloidosis presenting as breast masses, mammographically simulating carcinoma. Clin Radiol. 44(2):123-4, 1991
                                                                              15. Cheung PS et al: Bilateral amyloid tumours of the breast. Aust N Z J Surg. 56(4):375-7, 1986
                                                                              16. Silverman JF et al: Localized primary (AL) amyloid tumor of the breast. Cytologic, histologic, immunocytochemical and ultrastructural observations. Am J Surg Pathol. 10(8):539-45, 1986
                                                                              17. Baranets NA et al: [Prognostic value of determining the succinate dehydrogenase activity of lymphocytes and the therapeutic effectiveness of sodium succinate in resuscitation of rats.] Biull Eksp Biol Med. 100(10):405-7, 1985
                                                                              18. Hardy TJ et al: Diffuse parenchymal amyloidosis of lungs and breast. Its association with diffuse plasmacytosis and kappa-chain gammopathy. Arch Pathol Lab Med. 103(11):583-5, 1979
                                                                              19. Fernandez BB et al: Amyloid tumor of the breast. Arch Pathol. 95(2):102-5, 1973