Amyloidosis: Deposition of abnormal insoluble proteins within tissues throughout body
Localized vs. systemic: Localized disease or disease manifesting primarily in one organ vs. systemic disease
Localized to respiratory tract: Primarily AL
Systemic: Associated with AL, AA, ATTR, etc.
Primary: Associated with primary cell dyscrasias
Secondary: Associated with chronic infections or inflammatory disorders
Systemic AL: Formerly known as primary amyloidosis
Terms primary and secondary amyloidosis refer to chemical make-up of abnormalities
Primary: i.e., AL amyloidosis
Secondary: i.e., AA amyloidosis
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Schelbert EB et al: State of the Art: Clinical Applications of Cardiac T1 Mapping. Radiology. 278(3):658-76, 2016
Wechalekar AD et al: Systemic amyloidosis. Lancet. 387(10038):2641-54, 2016
Czeyda-Pommersheim F et al: Amyloidosis: modern cross-sectional imaging. Radiographics. 35(5):1381-92, 2015
Park MA et al: 18F-Florbetapir Binds Specifically to Myocardial Light Chain and Transthyretin Amyloid Deposits: Autoradiography Study. Circ Cardiovasc Imaging. 8(8), 2015
Baqir M et al: Amyloid-associated cystic lung disease in primary Sjögren's syndrome. Respir Med. 107(4):616-21, 2013
De Smet K et al: MRI in the assessment of non ischemic myocardial diseases. Eur J Radiol. 81(7):1546-8, 2012
Kang J et al: Manifestations of systemic diseases on thoracic imaging. Curr Probl Diagn Radiol. 39(6):247-61, 2010
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
Amyloid light chain (AL)
Serum amyloid A (AA)
Transthyretin amyloid (ATTR)
Amyloid β-2 microglobulin (Aβ2M)
Wild-type transthyretin amyloid (ATTRwt)
Lysozyme amyloid (ALys)
Gelsolin amyloid (AGel)
Definitions
Amyloidosis: Deposition of abnormal insoluble proteins within tissues throughout body
Localized vs. systemic: Localized disease or disease manifesting primarily in one organ vs. systemic disease
Localized to respiratory tract: Primarily AL
Systemic: Associated with AL, AA, ATTR, etc.
Primary: Associated with primary cell dyscrasias
Secondary: Associated with chronic infections or inflammatory disorders
Systemic AL: Formerly known as primary amyloidosis
Terms primary and secondary amyloidosis refer to chemical make-up of abnormalities
Primary: i.e., AL amyloidosis
Secondary: i.e., AA amyloidosis
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Schelbert EB et al: State of the Art: Clinical Applications of Cardiac T1 Mapping. Radiology. 278(3):658-76, 2016
Wechalekar AD et al: Systemic amyloidosis. Lancet. 387(10038):2641-54, 2016
Czeyda-Pommersheim F et al: Amyloidosis: modern cross-sectional imaging. Radiographics. 35(5):1381-92, 2015
Park MA et al: 18F-Florbetapir Binds Specifically to Myocardial Light Chain and Transthyretin Amyloid Deposits: Autoradiography Study. Circ Cardiovasc Imaging. 8(8), 2015
Baqir M et al: Amyloid-associated cystic lung disease in primary Sjögren's syndrome. Respir Med. 107(4):616-21, 2013
De Smet K et al: MRI in the assessment of non ischemic myocardial diseases. Eur J Radiol. 81(7):1546-8, 2012
Kang J et al: Manifestations of systemic diseases on thoracic imaging. Curr Probl Diagn Radiol. 39(6):247-61, 2010
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