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Amyloidosis
Siva P. Raman, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Clinical Issues

        TERMINOLOGY

        • Synonyms

          • Systemic amyloidosis
        • Definitions

          • Group of diseases characterized by deposition of abnormal protein (amyloid) in various tissues
            • May be systemic (involving multiple organs in 80%) or localized (in single organ or tissue in 20%)
            • Classified based on type of protein being deposited
              • AL and AA proteins by far most common
              • 30 different amyloidogenic proteins in humans
          • Primary: Due to monoclonal plasma cell dyscrasia (associated with no other underlying disease)
          • Secondary: Develops in setting of number of different chronic inflammatory diseases

        IMAGING

        • General Features

          • Fluoroscopic Findings

            • Imaging Recommendations

              • CT Findings

                • MR Findings

                  • Ultrasonographic Findings

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Gross Pathologic & Surgical Features

                          • Microscopic Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    Selected References

                                    1. Alkukhun A et al: Mesenteric amyloidosis: radiologic imaging with pathologic correlation. J Clin Imaging Sci. 10:24, 2020
                                    2. Özcan HN et al: Imaging for abdominal involvement in amyloidosis. Diagn Interv Radiol. 23(4):282-5, 2017
                                    3. Czeyda-Pommersheim F et al: Amyloidosis: modern cross-sectional imaging. Radiographics. 35(5):1381-92, 2015
                                    4. Loizos S et al: Amyloidosis: review and imaging findings. Semin Ultrasound CT MR. 35(3):225-39, 2014
                                    5. Sachchithanantham S et al: Imaging in systemic amyloidosis. Br Med Bull. 107:41-56, 2013
                                    6. Andrade MJ: Lower urinary tract dysfunction in familial amyloidotic polyneuropathy, Portuguese type. Neurourol Urodyn. 28(1):26-32, 2009
                                    7. Hirohata M et al: Non-steroidal anti-inflammatory drugs as anti-amyloidogenic compounds. Curr Pharm Des. 14(30):3280-94, 2008
                                    8. Georgiades CS et al: Amyloidosis: review and CT manifestations. Radiographics. 24(2):405-16, 2004
                                    9. Kim SH et al: Abdominal amyloidosis: spectrum of radiological findings. Clin Radiol. 58(8):610-20, 2003
                                    10. Urban BA et al: CT evaluation of amyloidosis: spectrum of disease. Radiographics. 13(6):1295-308, 1993
                                    Related Anatomy
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                                    Related Differential Diagnoses
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                                    References
                                    Tables

                                    Tables

                                    KEY FACTS

                                    • Terminology

                                      • Imaging

                                        • Clinical Issues

                                          TERMINOLOGY

                                          • Synonyms

                                            • Systemic amyloidosis
                                          • Definitions

                                            • Group of diseases characterized by deposition of abnormal protein (amyloid) in various tissues
                                              • May be systemic (involving multiple organs in 80%) or localized (in single organ or tissue in 20%)
                                              • Classified based on type of protein being deposited
                                                • AL and AA proteins by far most common
                                                • 30 different amyloidogenic proteins in humans
                                            • Primary: Due to monoclonal plasma cell dyscrasia (associated with no other underlying disease)
                                            • Secondary: Develops in setting of number of different chronic inflammatory diseases

                                          IMAGING

                                          • General Features

                                            • Fluoroscopic Findings

                                              • Imaging Recommendations

                                                • CT Findings

                                                  • MR Findings

                                                    • Ultrasonographic Findings

                                                      DIFFERENTIAL DIAGNOSIS

                                                        PATHOLOGY

                                                        • General Features

                                                          • Gross Pathologic & Surgical Features

                                                            • Microscopic Features

                                                              CLINICAL ISSUES

                                                              • Presentation

                                                                • Demographics

                                                                  • Natural History & Prognosis

                                                                    • Treatment

                                                                      Selected References

                                                                      1. Alkukhun A et al: Mesenteric amyloidosis: radiologic imaging with pathologic correlation. J Clin Imaging Sci. 10:24, 2020
                                                                      2. Özcan HN et al: Imaging for abdominal involvement in amyloidosis. Diagn Interv Radiol. 23(4):282-5, 2017
                                                                      3. Czeyda-Pommersheim F et al: Amyloidosis: modern cross-sectional imaging. Radiographics. 35(5):1381-92, 2015
                                                                      4. Loizos S et al: Amyloidosis: review and imaging findings. Semin Ultrasound CT MR. 35(3):225-39, 2014
                                                                      5. Sachchithanantham S et al: Imaging in systemic amyloidosis. Br Med Bull. 107:41-56, 2013
                                                                      6. Andrade MJ: Lower urinary tract dysfunction in familial amyloidotic polyneuropathy, Portuguese type. Neurourol Urodyn. 28(1):26-32, 2009
                                                                      7. Hirohata M et al: Non-steroidal anti-inflammatory drugs as anti-amyloidogenic compounds. Curr Pharm Des. 14(30):3280-94, 2008
                                                                      8. Georgiades CS et al: Amyloidosis: review and CT manifestations. Radiographics. 24(2):405-16, 2004
                                                                      9. Kim SH et al: Abdominal amyloidosis: spectrum of radiological findings. Clin Radiol. 58(8):610-20, 2003
                                                                      10. Urban BA et al: CT evaluation of amyloidosis: spectrum of disease. Radiographics. 13(6):1295-308, 1993