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Amyloidosis
Siva P. Raman, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Clinical Issues

        TERMINOLOGY

        • Synonyms

          • Systemic amyloidosis
        • Definitions

          • Group of diseases characterized by deposition of abnormal protein (amyloid) in various tissues
            • May be systemic (involving multiple organs in 80%) or localized (in single organ or tissue in 20%)
            • Classified based on type of protein being deposited
              • 30 different amyloidogenic proteins in humans
          • Primary: Due to monoclonal plasma cell dyscrasia (associated with no other underlying disease)
          • Secondary: Develops in setting of a number of different chronic inflammatory diseases

        IMAGING

        • General Features

          • Imaging Recommendations

            • Radiographic Findings

              • CT Findings

                • MR Findings

                  • Ultrasonographic Findings

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Gross Pathologic & Surgical Features

                          • Microscopic Features

                            CLINICAL ISSUES

                            • Presentation

                              • Treatment

                                Selected References

                                1. Loizos S et al: Amyloidosis: review and imaging findings. Semin Ultrasound CT MR. 35(3):225-39, 2014
                                2. Sachchithanantham S et al: Imaging in systemic amyloidosis. Br Med Bull. 107:41-56, 2013
                                3. Andrade MJ: Lower urinary tract dysfunction in familial amyloidotic polyneuropathy, Portuguese type. Neurourol Urodyn. 28(1):26-32, 2009
                                4. Hirohata M et al: Non-steroidal anti-inflammatory drugs as anti-amyloidogenic compounds. Curr Pharm Des. 14(30):3280-94, 2008
                                5. Georgiades CS et al: Amyloidosis: review and CT manifestations. Radiographics. 24(2):405-16, 2004
                                6. Kim SH et al: Abdominal amyloidosis: spectrum of radiological findings. Clin Radiol. 58(8):610-20, 2003
                                7. Urban BA et al: CT evaluation of amyloidosis: spectrum of disease. Radiographics. 13(6):1295-308, 1993
                                Related Anatomy
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                                Related Differential Diagnoses
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                                References
                                Tables

                                Tables

                                KEY FACTS

                                • Terminology

                                  • Imaging

                                    • Clinical Issues

                                      TERMINOLOGY

                                      • Synonyms

                                        • Systemic amyloidosis
                                      • Definitions

                                        • Group of diseases characterized by deposition of abnormal protein (amyloid) in various tissues
                                          • May be systemic (involving multiple organs in 80%) or localized (in single organ or tissue in 20%)
                                          • Classified based on type of protein being deposited
                                            • 30 different amyloidogenic proteins in humans
                                        • Primary: Due to monoclonal plasma cell dyscrasia (associated with no other underlying disease)
                                        • Secondary: Develops in setting of a number of different chronic inflammatory diseases

                                      IMAGING

                                      • General Features

                                        • Imaging Recommendations

                                          • Radiographic Findings

                                            • CT Findings

                                              • MR Findings

                                                • Ultrasonographic Findings

                                                  DIFFERENTIAL DIAGNOSIS

                                                    PATHOLOGY

                                                    • General Features

                                                      • Gross Pathologic & Surgical Features

                                                        • Microscopic Features

                                                          CLINICAL ISSUES

                                                          • Presentation

                                                            • Treatment

                                                              Selected References

                                                              1. Loizos S et al: Amyloidosis: review and imaging findings. Semin Ultrasound CT MR. 35(3):225-39, 2014
                                                              2. Sachchithanantham S et al: Imaging in systemic amyloidosis. Br Med Bull. 107:41-56, 2013
                                                              3. Andrade MJ: Lower urinary tract dysfunction in familial amyloidotic polyneuropathy, Portuguese type. Neurourol Urodyn. 28(1):26-32, 2009
                                                              4. Hirohata M et al: Non-steroidal anti-inflammatory drugs as anti-amyloidogenic compounds. Curr Pharm Des. 14(30):3280-94, 2008
                                                              5. Georgiades CS et al: Amyloidosis: review and CT manifestations. Radiographics. 24(2):405-16, 2004
                                                              6. Kim SH et al: Abdominal amyloidosis: spectrum of radiological findings. Clin Radiol. 58(8):610-20, 2003
                                                              7. Urban BA et al: CT evaluation of amyloidosis: spectrum of disease. Radiographics. 13(6):1295-308, 1993