To access 4,300 diagnoses written by the world's leading experts in radiology, please log in or subscribe.Log inSubscribe
1
5
0
0
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
Amyotrophic lateral sclerosis (ALS)
Synonyms
Lou Gehrig disease, motor neuron disease (MND)
Definitions
Selective degeneration of somatic motor neurons of brainstem/spinal cord {lower motor neurons (LMN) & large pyramidal neurons of motor cortex [upper motor neurons (UMN)]}
Eventual loss of corticospinal tract (CST) fibers
IMAGING
General Features
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Braun N et al: The revised El Escorial criteria "clinically probable laboratory supported ALS"-once a promising now a superfluous category? Amyotroph Lateral Scler Frontotemporal Degener. 1-5, 2019
Lai JD et al: C9ORF72 protein function and immune dysregulation in amyotrophic lateral sclerosis. Neurosci Lett. 134523, 2019
Barthel H et al: PET/MR in dementia and other neurodegenerative diseases. Semin Nucl Med. 45(3):224-33, 2015
Goveas J et al: Diffusion-MRI in neurodegenerative disorders. Magn Reson Imaging. 33(7):853-76, 2015
Verstraete E et al: Neuroimaging as a new diagnostic modality in amyotrophic lateral sclerosis. Neurotherapeutics. 12(2):403-16, 2015
Chiò A et al: Neuroimaging in amyotrophic lateral sclerosis: insights into structural and functional changes. Lancet Neurol. 13(12):1228-40, 2014
Vucic S et al: Advances in treating amyotrophic lateral sclerosis: insights from pathophysiological studies. Trends Neurosci. 37(8):433-42, 2014
Wang S et al: Neuroimaging in amyotrophic lateral sclerosis. Neurotherapeutics. 8(1):63-71, 2011
Filippi M et al: EFNS guidelines on the use of neuroimaging in the management of motor neuron diseases. Eur J Neurol. 17(4):526-e20, 2010
Sage CA et al: Quantitative diffusion tensor imaging in amyotrophic lateral sclerosis. Neuroimage. 34(2):486-99, 2007
Unrath A et al: Brain metabolites in definite amyotrophic lateral sclerosis. A longitudinal proton magnetic resonance spectroscopy study. J Neurol. 254(8):1099-106, 2007
Kalra S et al: Rapid improvement in cortical neuronal integrity in amyotrophic lateral sclerosis detected by proton magnetic resonance spectroscopic imaging. J Neurol. 253(8):1060-3, 2006
Cosottini M et al: Diffusion-tensor MR imaging of corticospinal tract in amyotrophic lateral sclerosis and progressive muscular atrophy. Radiology. 237(1):258-64, 2005
Sach M et al: Diffusion tensor MRI of early upper motor neuron involvement in amyotrophic lateral sclerosis. Brain. 127(Pt 2):340-50, 2004
Kalra S et al: Gabapentin therapy for amyotrophic lateral sclerosis: lack of improvement in neuronal integrity shown by MR spectroscopy. AJNR Am J Neuroradiol. 24(3):476-80, 2003
Kalra S et al: Neuroimaging in amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord. 4(4):243-8, 2003
Strong M et al: Amyotrophic lateral sclerosis: a review of current concepts. Amyotroph Lateral Scler Other Motor Neuron Disord. 4(3):136-43, 2003
Heath PR et al: Update on the glutamatergic neurotransmitter system and the role of excitotoxicity in amyotrophic lateral sclerosis. Muscle Nerve. 26(4):438-58, 2002
Bowen BC et al: MR imaging and localized proton spectroscopy of the precentral gyrus in amyotrophic lateral sclerosis. AJNR Am J Neuroradiol. 21(4):647-58, 2000
Chan S et al: Motor neuron diseases: comparison of single-voxel proton MR spectroscopy of the motor cortex with MR imaging of the brain. Radiology. 212(3):763-9, 1999
Ellis CM et al: Diffusion tensor MRI assesses corticospinal tract damage in ALS. Neurology. 53(5):1051-8, 1999
Kato Y et al: Detection of pyramidal tract lesions in amyotrophic lateral sclerosis with magnetization-transfer measurements. AJNR Am J Neuroradiol. 18(8):1541-7, 1997
Mascalchi M et al: Corticospinal tract degeneration in motor neuron disease. AJNR Am J Neuroradiol. 16(4 Suppl):878-80, 1995
Related Anatomy
Loading...
Related Differential Diagnoses
Loading...
References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
Amyotrophic lateral sclerosis (ALS)
Synonyms
Lou Gehrig disease, motor neuron disease (MND)
Definitions
Selective degeneration of somatic motor neurons of brainstem/spinal cord {lower motor neurons (LMN) & large pyramidal neurons of motor cortex [upper motor neurons (UMN)]}
Eventual loss of corticospinal tract (CST) fibers
IMAGING
General Features
CT Findings
MR Findings
Nuclear Medicine Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Braun N et al: The revised El Escorial criteria "clinically probable laboratory supported ALS"-once a promising now a superfluous category? Amyotroph Lateral Scler Frontotemporal Degener. 1-5, 2019
Lai JD et al: C9ORF72 protein function and immune dysregulation in amyotrophic lateral sclerosis. Neurosci Lett. 134523, 2019
Barthel H et al: PET/MR in dementia and other neurodegenerative diseases. Semin Nucl Med. 45(3):224-33, 2015
Goveas J et al: Diffusion-MRI in neurodegenerative disorders. Magn Reson Imaging. 33(7):853-76, 2015
Verstraete E et al: Neuroimaging as a new diagnostic modality in amyotrophic lateral sclerosis. Neurotherapeutics. 12(2):403-16, 2015
Chiò A et al: Neuroimaging in amyotrophic lateral sclerosis: insights into structural and functional changes. Lancet Neurol. 13(12):1228-40, 2014
Vucic S et al: Advances in treating amyotrophic lateral sclerosis: insights from pathophysiological studies. Trends Neurosci. 37(8):433-42, 2014
Wang S et al: Neuroimaging in amyotrophic lateral sclerosis. Neurotherapeutics. 8(1):63-71, 2011
Filippi M et al: EFNS guidelines on the use of neuroimaging in the management of motor neuron diseases. Eur J Neurol. 17(4):526-e20, 2010
Sage CA et al: Quantitative diffusion tensor imaging in amyotrophic lateral sclerosis. Neuroimage. 34(2):486-99, 2007
Unrath A et al: Brain metabolites in definite amyotrophic lateral sclerosis. A longitudinal proton magnetic resonance spectroscopy study. J Neurol. 254(8):1099-106, 2007
Kalra S et al: Rapid improvement in cortical neuronal integrity in amyotrophic lateral sclerosis detected by proton magnetic resonance spectroscopic imaging. J Neurol. 253(8):1060-3, 2006
Cosottini M et al: Diffusion-tensor MR imaging of corticospinal tract in amyotrophic lateral sclerosis and progressive muscular atrophy. Radiology. 237(1):258-64, 2005
Sach M et al: Diffusion tensor MRI of early upper motor neuron involvement in amyotrophic lateral sclerosis. Brain. 127(Pt 2):340-50, 2004
Kalra S et al: Gabapentin therapy for amyotrophic lateral sclerosis: lack of improvement in neuronal integrity shown by MR spectroscopy. AJNR Am J Neuroradiol. 24(3):476-80, 2003
Kalra S et al: Neuroimaging in amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord. 4(4):243-8, 2003
Strong M et al: Amyotrophic lateral sclerosis: a review of current concepts. Amyotroph Lateral Scler Other Motor Neuron Disord. 4(3):136-43, 2003
Heath PR et al: Update on the glutamatergic neurotransmitter system and the role of excitotoxicity in amyotrophic lateral sclerosis. Muscle Nerve. 26(4):438-58, 2002
Bowen BC et al: MR imaging and localized proton spectroscopy of the precentral gyrus in amyotrophic lateral sclerosis. AJNR Am J Neuroradiol. 21(4):647-58, 2000
Chan S et al: Motor neuron diseases: comparison of single-voxel proton MR spectroscopy of the motor cortex with MR imaging of the brain. Radiology. 212(3):763-9, 1999
Ellis CM et al: Diffusion tensor MRI assesses corticospinal tract damage in ALS. Neurology. 53(5):1051-8, 1999
Kato Y et al: Detection of pyramidal tract lesions in amyotrophic lateral sclerosis with magnetization-transfer measurements. AJNR Am J Neuroradiol. 18(8):1541-7, 1997
Mascalchi M et al: Corticospinal tract degeneration in motor neuron disease. AJNR Am J Neuroradiol. 16(4 Suppl):878-80, 1995
STATdx includes over 200,000 searchable images, including x-ray, CT, MR and ultrasound images. To access all images, please log in or subscribe.