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Anaplastic Pleomorphic Xanthoastrocytoma
Miral D. Jhaveri, MD, MBA
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Anaplastic pleomorphic xanthoastrocytoma (aPXA)
                • Pleomorphic xanthoastrocytoma (PXA)
              • Definitions

                • PXA with anaplastic features, ≥ 5 mitoses/10 HPF

              IMAGING

              • General Features

                • CT Findings

                  • MR Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Staging, Grading, & Classification

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          Selected References

                                          1. Phillips JJ et al: The genetic landscape of anaplastic pleomorphic xanthoastrocytoma. Brain Pathol. 29(1):85-96, 2019
                                          2. Thomas AA et al: Anaplastic pleomorphic xanthoastrocytoma with leptomeningeal dissemination responsive to BRAF inhibition and bevacizumab. Pediatr Blood Cancer. 66(1):e27465, 2019
                                          3. Pradhan P et al: Clinico-histomorphological and immunohistochemical profile of anaplastic pleomorphic xanthoastrocytoma: report of five cases and review of literature. Int J Hematol Oncol Stem Cell Res. 12(4):265-72, 2018
                                          4. She D et al: MR Imaging features of anaplastic pleomorphic xanthoastrocytoma mimicking high-grade astrocytoma. AJNR Am J Neuroradiol. 39(8):1446-52, 2018
                                          5. Wesseling P et al: WHO 2016 Classification of gliomas. Neuropathol Appl Neurobiol. 44(2):139-50, 2018
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Top Differential Diagnoses

                                                • Pathology

                                                  • Clinical Issues

                                                    • Diagnostic Checklist

                                                      TERMINOLOGY

                                                      • Abbreviations

                                                        • Anaplastic pleomorphic xanthoastrocytoma (aPXA)
                                                        • Pleomorphic xanthoastrocytoma (PXA)
                                                      • Definitions

                                                        • PXA with anaplastic features, ≥ 5 mitoses/10 HPF

                                                      IMAGING

                                                      • General Features

                                                        • CT Findings

                                                          • MR Findings

                                                            • Imaging Recommendations

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • General Features

                                                                  • Staging, Grading, & Classification

                                                                    • Gross Pathologic & Surgical Features

                                                                      • Microscopic Features

                                                                        CLINICAL ISSUES

                                                                        • Presentation

                                                                          • Demographics

                                                                            • Natural History & Prognosis

                                                                              • Treatment

                                                                                DIAGNOSTIC CHECKLIST

                                                                                • Consider

                                                                                  Selected References

                                                                                  1. Phillips JJ et al: The genetic landscape of anaplastic pleomorphic xanthoastrocytoma. Brain Pathol. 29(1):85-96, 2019
                                                                                  2. Thomas AA et al: Anaplastic pleomorphic xanthoastrocytoma with leptomeningeal dissemination responsive to BRAF inhibition and bevacizumab. Pediatr Blood Cancer. 66(1):e27465, 2019
                                                                                  3. Pradhan P et al: Clinico-histomorphological and immunohistochemical profile of anaplastic pleomorphic xanthoastrocytoma: report of five cases and review of literature. Int J Hematol Oncol Stem Cell Res. 12(4):265-72, 2018
                                                                                  4. She D et al: MR Imaging features of anaplastic pleomorphic xanthoastrocytoma mimicking high-grade astrocytoma. AJNR Am J Neuroradiol. 39(8):1446-52, 2018
                                                                                  5. Wesseling P et al: WHO 2016 Classification of gliomas. Neuropathol Appl Neurobiol. 44(2):139-50, 2018