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Anaplastic Thyroid Carcinoma
Robert M Morgan, Jr., MD; Paige Bennett, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Clinical Issues

        TERMINOLOGY

        • Definitions

          • Anaplastic thyroid cancer (ATC)
            • Rare, very aggressive undifferentiated solid tumor arising from thyroid follicular epithelium
            • Unlike many other nonaggressive thyroid cancers, ATC has low avidity for iodine and typically has no uptake on radioactive iodine scans

        IMAGING

        • F-18 FDG PET/CT

          • CT

            • MR

              • Ultrasound

                DIFFERENTIAL DIAGNOSIS

                  PATHOLOGY

                  • General Features

                    • Staging, Grading, & Classification

                      CLINICAL ISSUES

                      • Treatment

                        DIAGNOSTIC CHECKLIST

                        • Reporting Tips

                          Selected References

                          1. Keutgen XM et al: Management of anaplastic thyroid cancer. Electron Kebebew Gland Surg. 4(1): 44–51, 2014
                          2. Suh HJ et al: Anaplastic thyroid cancer: ultrasonographic findings and the role of ultrasonography-guided fine needle aspiration biopsy. Yonsei Med J. 54(6):1400-6, 2013
                          3. Mosci C et al: PET/CT imaging of thyroid cancer. Clin Nucl Med. 36(12):e180-5, 2011
                          4. Nagaiah G et al: Anaplastic thyroid cancer: a review of epidemiology, pathogenesis, and treatment. J Oncol. 2011:542358, 2011
                          5. Poisson T et al: 18F-fluorodeoxyglucose positron emission tomography and computed tomography in anaplastic thyroid cancer. Eur J Nucl Med Mol Imaging. 37(12):2277-85, 2010
                          6. Bogsrud TV et al: 18F-FDG PET in the management of patients with anaplastic thyroid carcinoma. Thyroid. 18(7):713-9, 2008
                          7. Chiacchio S et al: Anaplastic thyroid cancer: prevalence, diagnosis and treatment. Minerva Endocrinol. 33(4):341-57, 2008
                          8. Neff RL et al: Anaplastic thyroid cancer. Endocrinol Metab Clin North Am. 37(2):525-38, xi, 2008
                          9. Hoang JK et al: US Features of thyroid malignancy: pearls and pitfalls. Radiographics. 27(3):847-60; discussion 861-5, 2007
                          10. Miyakoshi A et al: Magnetic resonance imaging of thyroid cancer. Top Magn Reson Imaging. 18(4):293-302, 2007
                          11. Giuffrida D et al: Anaplastic thyroid carcinoma: current diagnosis and treatment. Ann Oncol. 11(9):1083-9, 2000
                          12. Takashima S et al: CT evaluation of anaplastic thyroid carcinoma. AJR Am J Roentgenol. 154(5):1079-85, 1990
                          13. Dembicki EL: Feminine hygiene today. J Psychiatr Nurs Ment Health Serv. 8(5):36-7, 1970
                          Related Anatomy
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                          Related Differential Diagnoses
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                          References
                          Tables

                          Tables

                          KEY FACTS

                          • Terminology

                            • Imaging

                              • Clinical Issues

                                TERMINOLOGY

                                • Definitions

                                  • Anaplastic thyroid cancer (ATC)
                                    • Rare, very aggressive undifferentiated solid tumor arising from thyroid follicular epithelium
                                    • Unlike many other nonaggressive thyroid cancers, ATC has low avidity for iodine and typically has no uptake on radioactive iodine scans

                                IMAGING

                                • F-18 FDG PET/CT

                                  • CT

                                    • MR

                                      • Ultrasound

                                        DIFFERENTIAL DIAGNOSIS

                                          PATHOLOGY

                                          • General Features

                                            • Staging, Grading, & Classification

                                              CLINICAL ISSUES

                                              • Treatment

                                                DIAGNOSTIC CHECKLIST

                                                • Reporting Tips

                                                  Selected References

                                                  1. Keutgen XM et al: Management of anaplastic thyroid cancer. Electron Kebebew Gland Surg. 4(1): 44–51, 2014
                                                  2. Suh HJ et al: Anaplastic thyroid cancer: ultrasonographic findings and the role of ultrasonography-guided fine needle aspiration biopsy. Yonsei Med J. 54(6):1400-6, 2013
                                                  3. Mosci C et al: PET/CT imaging of thyroid cancer. Clin Nucl Med. 36(12):e180-5, 2011
                                                  4. Nagaiah G et al: Anaplastic thyroid cancer: a review of epidemiology, pathogenesis, and treatment. J Oncol. 2011:542358, 2011
                                                  5. Poisson T et al: 18F-fluorodeoxyglucose positron emission tomography and computed tomography in anaplastic thyroid cancer. Eur J Nucl Med Mol Imaging. 37(12):2277-85, 2010
                                                  6. Bogsrud TV et al: 18F-FDG PET in the management of patients with anaplastic thyroid carcinoma. Thyroid. 18(7):713-9, 2008
                                                  7. Chiacchio S et al: Anaplastic thyroid cancer: prevalence, diagnosis and treatment. Minerva Endocrinol. 33(4):341-57, 2008
                                                  8. Neff RL et al: Anaplastic thyroid cancer. Endocrinol Metab Clin North Am. 37(2):525-38, xi, 2008
                                                  9. Hoang JK et al: US Features of thyroid malignancy: pearls and pitfalls. Radiographics. 27(3):847-60; discussion 861-5, 2007
                                                  10. Miyakoshi A et al: Magnetic resonance imaging of thyroid cancer. Top Magn Reson Imaging. 18(4):293-302, 2007
                                                  11. Giuffrida D et al: Anaplastic thyroid carcinoma: current diagnosis and treatment. Ann Oncol. 11(9):1083-9, 2000
                                                  12. Takashima S et al: CT evaluation of anaplastic thyroid carcinoma. AJR Am J Roentgenol. 154(5):1079-85, 1990
                                                  13. Dembicki EL: Feminine hygiene today. J Psychiatr Nurs Ment Health Serv. 8(5):36-7, 1970