Multilocular hematic cyst, giant cell reparative granuloma of small bone
Definitions
Benign cystic neoplasm of bone composed of blood-filled spaces separated by connective tissue septa
Term secondary ABC has been replaced with ABC-like change when associated with other bone tumors
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Imaging Recommendations
Nuclear Medicine Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
Bavan L et al: Efficacy of treatment interventions for primary aneurysmal bone cysts: a systematic review. Bone Jt Open. 2(2):125-33, 2021
Agaram NP et al: Aneurysmal bone cyst. In Fletcher CDM et al: World Health Organization Classification of Tumors: Tumours of Soft Tissue and Bone. IARC Press. 437-9, 2020
Zishan US et al: The differentiation between aneurysmal bone cyst and telangiectatic osteosarcoma: a clinical, radiographic and MRI study. Skeletal Radiol. 49(9):1375-86, 2020
Alhumaid I et al: Denosumab therapy in the management of aneurysmal bone cysts: a comprehensive literature review. Cureus. 11(1):e3989, 2019
Doyle A et al: Recurrent aneurysmal bone cyst of the cervical spine in childhood treated with doxycycline injection. Skeletal Radiol.44(4):609-12, 2015
Boriani S et al: Aneurysmal bone cysts of the spine: treatment options and considerations. J Neurooncol. 120(1):171-8, 2014
Chung JW et al: Secondary aneurysmal bone cystic change of the chondroblastoma, mistaken for a primary aneurysmal bone cyst in the patella. Knee Surg Relat Res. 26(1):48-51, 2014
Pauli C et al: Response of an aggressive periosteal aneurysmal bone cyst (ABC) of the radius to denosumab therapy. World J Surg Oncol. 12:17, 2014
Reddy KI et al: Aneurysmal bone cysts: do simple treatments work? Clin Orthop Relat Res. 472(6):1901-10, 2014
Marushima A et al: Selective arterial embolization with n-butyl cyanoacrylate in the treatment of aneursymal bone cyst of the thoracic vertebra: a case report. Spine (Phila Pa 1976). 34(6):E230-4, 2009
Ruggieri P et al: Tumours and tumour-like lesions of the hip in the paediatric age: a review of the Rizzoli experience. Hip Int. 19 Suppl 6:S35-45, 2009
Burch S et al: Aneurysmal bone cysts of the spine. Neurosurg Clin N Am. 19(1):41-7, 2008
Lin PP et al: Aneurysmal bone cysts recur at juxtaphyseal locations in skeletally immature patients. Clin Orthop Relat Res. 466(3):722-8, 2008
Rodallec MH et al: Diagnostic imaging of solitary tumors of the spine: what to do and say. Radiographics. 28(4):1019-41, 2008
Başarir K et al: Aneurysmal bone cyst recurrence in children: a review of 56 patients. J Pediatr Orthop. 27(8):938-43, 2007
Cottalorda J et al: Modern concepts of primary aneurysmal bone cyst. Arch Orthop Trauma Surg. 127(2):105-14, 2007
Ellison DA et al: Soft-tissue aneurysmal bone cyst: report of a case with t(5;17)(q33;p13). Pediatr Dev Pathol. 10(1):46-9, 2007
Kenney B et al: Solid variant of aneurysmal bone cyst with a novel (X;9) translocation. Cancer Genet Cytogenet. 178(2):155-9, 2007
Lampasi M et al: Aneurysmal bone cysts of the distal fibula in children: long-term results of curettage and resection in nine patients. J Bone Joint Surg Br. 89(10):1356-62, 2007
Cottalorda J et al: Current treatments of primary aneurysmal bone cysts. J Pediatr Orthop B. 15(3):155-67, 2006
Mendenhall WM et al: Aneurysmal bone cyst. Am J Clin Oncol. 29(3):311-5, 2006
Rastogi S et al: Treatment of aneurysmal bone cysts with percutaneous sclerotherapy using polidocanol. A review of 72 cases with long-term follow-up. J Bone Joint Surg Br. 88(9):1212-6, 2006
Van Dyck P et al: Prevalence, extension and characteristics of fluid-fluid levels in bone and soft tissue tumors. Eur Radiol. 16(12):2644-51, 2006
Ilaslan H et al: Solid variant of aneurysmal bone cysts in long tubular bones: giant cell reparative granuloma. AJR Am J Roentgenol. 180(6):1681-7, 2003
Kransdorf MJ et al: Aneurysmal bone cyst: concept, controversy, clinical presentation, and imaging. AJR Am J Roentgenol. 164(3):573-80, 1995
Vergel De Dios AM et al: Aneurysmal bone cyst. A clinicopathologic study of 238 cases. Cancer. 69(12):2921-31, 1992
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
Aneurysmal bone cyst (ABC)
Synonyms
Multilocular hematic cyst, giant cell reparative granuloma of small bone
Definitions
Benign cystic neoplasm of bone composed of blood-filled spaces separated by connective tissue septa
Term secondary ABC has been replaced with ABC-like change when associated with other bone tumors
IMAGING
General Features
Radiographic Findings
CT Findings
MR Findings
Imaging Recommendations
Nuclear Medicine Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
Bavan L et al: Efficacy of treatment interventions for primary aneurysmal bone cysts: a systematic review. Bone Jt Open. 2(2):125-33, 2021
Agaram NP et al: Aneurysmal bone cyst. In Fletcher CDM et al: World Health Organization Classification of Tumors: Tumours of Soft Tissue and Bone. IARC Press. 437-9, 2020
Zishan US et al: The differentiation between aneurysmal bone cyst and telangiectatic osteosarcoma: a clinical, radiographic and MRI study. Skeletal Radiol. 49(9):1375-86, 2020
Alhumaid I et al: Denosumab therapy in the management of aneurysmal bone cysts: a comprehensive literature review. Cureus. 11(1):e3989, 2019
Doyle A et al: Recurrent aneurysmal bone cyst of the cervical spine in childhood treated with doxycycline injection. Skeletal Radiol.44(4):609-12, 2015
Boriani S et al: Aneurysmal bone cysts of the spine: treatment options and considerations. J Neurooncol. 120(1):171-8, 2014
Chung JW et al: Secondary aneurysmal bone cystic change of the chondroblastoma, mistaken for a primary aneurysmal bone cyst in the patella. Knee Surg Relat Res. 26(1):48-51, 2014
Pauli C et al: Response of an aggressive periosteal aneurysmal bone cyst (ABC) of the radius to denosumab therapy. World J Surg Oncol. 12:17, 2014
Reddy KI et al: Aneurysmal bone cysts: do simple treatments work? Clin Orthop Relat Res. 472(6):1901-10, 2014
Marushima A et al: Selective arterial embolization with n-butyl cyanoacrylate in the treatment of aneursymal bone cyst of the thoracic vertebra: a case report. Spine (Phila Pa 1976). 34(6):E230-4, 2009
Ruggieri P et al: Tumours and tumour-like lesions of the hip in the paediatric age: a review of the Rizzoli experience. Hip Int. 19 Suppl 6:S35-45, 2009
Burch S et al: Aneurysmal bone cysts of the spine. Neurosurg Clin N Am. 19(1):41-7, 2008
Lin PP et al: Aneurysmal bone cysts recur at juxtaphyseal locations in skeletally immature patients. Clin Orthop Relat Res. 466(3):722-8, 2008
Rodallec MH et al: Diagnostic imaging of solitary tumors of the spine: what to do and say. Radiographics. 28(4):1019-41, 2008
Başarir K et al: Aneurysmal bone cyst recurrence in children: a review of 56 patients. J Pediatr Orthop. 27(8):938-43, 2007
Cottalorda J et al: Modern concepts of primary aneurysmal bone cyst. Arch Orthop Trauma Surg. 127(2):105-14, 2007
Ellison DA et al: Soft-tissue aneurysmal bone cyst: report of a case with t(5;17)(q33;p13). Pediatr Dev Pathol. 10(1):46-9, 2007
Kenney B et al: Solid variant of aneurysmal bone cyst with a novel (X;9) translocation. Cancer Genet Cytogenet. 178(2):155-9, 2007
Lampasi M et al: Aneurysmal bone cysts of the distal fibula in children: long-term results of curettage and resection in nine patients. J Bone Joint Surg Br. 89(10):1356-62, 2007
Cottalorda J et al: Current treatments of primary aneurysmal bone cysts. J Pediatr Orthop B. 15(3):155-67, 2006
Mendenhall WM et al: Aneurysmal bone cyst. Am J Clin Oncol. 29(3):311-5, 2006
Rastogi S et al: Treatment of aneurysmal bone cysts with percutaneous sclerotherapy using polidocanol. A review of 72 cases with long-term follow-up. J Bone Joint Surg Br. 88(9):1212-6, 2006
Van Dyck P et al: Prevalence, extension and characteristics of fluid-fluid levels in bone and soft tissue tumors. Eur Radiol. 16(12):2644-51, 2006
Ilaslan H et al: Solid variant of aneurysmal bone cysts in long tubular bones: giant cell reparative granuloma. AJR Am J Roentgenol. 180(6):1681-7, 2003
Kransdorf MJ et al: Aneurysmal bone cyst: concept, controversy, clinical presentation, and imaging. AJR Am J Roentgenol. 164(3):573-80, 1995
Vergel De Dios AM et al: Aneurysmal bone cyst. A clinicopathologic study of 238 cases. Cancer. 69(12):2921-31, 1992
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