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Aneurysmal Bone Cyst
Kevin R. Moore, MD
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KEY FACTS

  • Imaging

    • Top Differential Diagnoses

      • Pathology

        • Clinical Issues

          TERMINOLOGY

          • Definitions

            • Expansile benign neoplasm containing thin-walled, blood-filled cavities

          IMAGING

          • General Features

            • Radiographic Findings

              • CT Findings

                • MR Findings

                  • Angiographic Findings

                    • Nuclear Medicine Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                • Genetics

                                  CLINICAL ISSUES

                                  • Presentation

                                    • Demographics

                                      • Natural History & Prognosis

                                        • Treatment

                                          DIAGNOSTIC CHECKLIST

                                          • Consider

                                            • Image Interpretation Pearls

                                              Selected References

                                              1. Oliveira AM et al: USP6-induced neoplasms: the biologic spectrum of aneurysmal bone cyst and nodular fasciitis. Hum Pathol. 45(1):1-11, 2014
                                              2. Amendola L et al: Aneurysmal bone cyst of the mobile spine: the therapeutic role of embolization. Eur Spine J. 22(3):533-41, 2013
                                              3. Zileli M et al: Aneurysmal bone cysts of the spine. Eur Spine J. 22(3):593-601, 2013
                                              4. Oliveira AM et al: The TRE17/USP6 oncogene: a riddle wrapped in a mystery inside an enigma. Front Biosci (Schol Ed). 4:321-34, 2012
                                              5. Ye Y et al: TRE17/USP6 oncogene translocated in aneurysmal bone cyst induces matrix metalloproteinase production via activation of NF-kappaB. Oncogene. 29(25):3619-29, 2010
                                              6. Brastianos P et al: Aneurysmal bone cysts of the sacrum: a report of ten cases and review of the literature. Iowa Orthop J. 29:74-8, 2009
                                              7. Mankin HJ et al: Aneurysmal bone cyst: a review of 150 patients. J Clin Oncol. 23(27):6756-62, 2005
                                              8. Garneti N et al: Cervical spondyloptosis caused by an aneurysmal bone cyst: a case report. Spine. 28(4):E68-70, 2003
                                              9. Lomasney LM et al: Fibrous dysplasia complicated by aneurysmal bone cyst formation affecting multiple cervical vertebrae. Skeletal Radiol. 32(9):533-6, 2003
                                              10. Pogoda P et al: Aneurysmal bone cysts of the sacrum. Clinical report and review of the literature. Arch Orthop Trauma Surg. 123(5):247-51, 2003
                                              11. Chan MS et al: Spinal aneurysmal bone cyst causing acute cord compression without vertebral collapse: CT and MRI findings. Pediatr Radiol. 32(8):601-4, 2002
                                              12. Lam CH et al: Nonteratomatous tumors in the pediatric sacral region. Spine. 27(11):E284-7, 2002
                                              13. Boriani S et al: Aneurysmal bone cyst of the mobile spine: report on 41 cases. Spine. 26(1):27-35, 2001
                                              14. Papagelopoulos PJ et al: Treatment of aneurysmal bone cysts of the pelvis and sacrum. J Bone Joint Surg Am. 83-A(11):1674-81, 2001
                                              15. Bush CH et al: Treatment of an aneurysmal bone cyst of the spine by radionuclide ablation. AJNR Am J Neuroradiol. 21(3):592-4, 2000
                                              16. DiCaprio MR et al: Aneurysmal bone cyst of the spine with familial incidence. Spine. 25(12):1589-92, 2000
                                              17. Ozaki T et al: Aneurysmal bone cysts of the spine. Arch Orthop Trauma Surg. 119(3-4):159-62, 1999
                                              18. de Kleuver M et al: Aneurysmal bone cyst of the spine: 31 cases and the importance of the surgical approach. J Pediatr Orthop B. 7(4):286-92, 1998
                                              19. Papagelopoulos PJ et al: Aneurysmal bone cyst of the spine. Management and outcome. Spine. 23(5):621-8, 1998
                                              20. Murphey MD et al: From the archives of the AFIP. Primary tumors of the spine: radiologic pathologic correlation. Radiographics. 16(5):1131-58, 1996
                                              21. Koci TM et al: Aneurysmal bone cyst of the thoracic spine: evolution after particulate embolization. AJNR Am J Neuroradiol. 16(4 Suppl):857-60, 1995
                                              22. Kransdorf MJ et al: Aneurysmal bone cyst: concept, controversy, clinical presentation, and imaging. AJR Am J Roentgenol. 164(3):573-80, 1995
                                              Related Anatomy
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                                              Related Differential Diagnoses
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                                              References
                                              Tables

                                              Tables

                                              KEY FACTS

                                              • Imaging

                                                • Top Differential Diagnoses

                                                  • Pathology

                                                    • Clinical Issues

                                                      TERMINOLOGY

                                                      • Definitions

                                                        • Expansile benign neoplasm containing thin-walled, blood-filled cavities

                                                      IMAGING

                                                      • General Features

                                                        • Radiographic Findings

                                                          • CT Findings

                                                            • MR Findings

                                                              • Angiographic Findings

                                                                • Nuclear Medicine Findings

                                                                  • Imaging Recommendations

                                                                    DIFFERENTIAL DIAGNOSIS

                                                                      PATHOLOGY

                                                                      • General Features

                                                                        • Gross Pathologic & Surgical Features

                                                                          • Microscopic Features

                                                                            • Genetics

                                                                              CLINICAL ISSUES

                                                                              • Presentation

                                                                                • Demographics

                                                                                  • Natural History & Prognosis

                                                                                    • Treatment

                                                                                      DIAGNOSTIC CHECKLIST

                                                                                      • Consider

                                                                                        • Image Interpretation Pearls

                                                                                          Selected References

                                                                                          1. Oliveira AM et al: USP6-induced neoplasms: the biologic spectrum of aneurysmal bone cyst and nodular fasciitis. Hum Pathol. 45(1):1-11, 2014
                                                                                          2. Amendola L et al: Aneurysmal bone cyst of the mobile spine: the therapeutic role of embolization. Eur Spine J. 22(3):533-41, 2013
                                                                                          3. Zileli M et al: Aneurysmal bone cysts of the spine. Eur Spine J. 22(3):593-601, 2013
                                                                                          4. Oliveira AM et al: The TRE17/USP6 oncogene: a riddle wrapped in a mystery inside an enigma. Front Biosci (Schol Ed). 4:321-34, 2012
                                                                                          5. Ye Y et al: TRE17/USP6 oncogene translocated in aneurysmal bone cyst induces matrix metalloproteinase production via activation of NF-kappaB. Oncogene. 29(25):3619-29, 2010
                                                                                          6. Brastianos P et al: Aneurysmal bone cysts of the sacrum: a report of ten cases and review of the literature. Iowa Orthop J. 29:74-8, 2009
                                                                                          7. Mankin HJ et al: Aneurysmal bone cyst: a review of 150 patients. J Clin Oncol. 23(27):6756-62, 2005
                                                                                          8. Garneti N et al: Cervical spondyloptosis caused by an aneurysmal bone cyst: a case report. Spine. 28(4):E68-70, 2003
                                                                                          9. Lomasney LM et al: Fibrous dysplasia complicated by aneurysmal bone cyst formation affecting multiple cervical vertebrae. Skeletal Radiol. 32(9):533-6, 2003
                                                                                          10. Pogoda P et al: Aneurysmal bone cysts of the sacrum. Clinical report and review of the literature. Arch Orthop Trauma Surg. 123(5):247-51, 2003
                                                                                          11. Chan MS et al: Spinal aneurysmal bone cyst causing acute cord compression without vertebral collapse: CT and MRI findings. Pediatr Radiol. 32(8):601-4, 2002
                                                                                          12. Lam CH et al: Nonteratomatous tumors in the pediatric sacral region. Spine. 27(11):E284-7, 2002
                                                                                          13. Boriani S et al: Aneurysmal bone cyst of the mobile spine: report on 41 cases. Spine. 26(1):27-35, 2001
                                                                                          14. Papagelopoulos PJ et al: Treatment of aneurysmal bone cysts of the pelvis and sacrum. J Bone Joint Surg Am. 83-A(11):1674-81, 2001
                                                                                          15. Bush CH et al: Treatment of an aneurysmal bone cyst of the spine by radionuclide ablation. AJNR Am J Neuroradiol. 21(3):592-4, 2000
                                                                                          16. DiCaprio MR et al: Aneurysmal bone cyst of the spine with familial incidence. Spine. 25(12):1589-92, 2000
                                                                                          17. Ozaki T et al: Aneurysmal bone cysts of the spine. Arch Orthop Trauma Surg. 119(3-4):159-62, 1999
                                                                                          18. de Kleuver M et al: Aneurysmal bone cyst of the spine: 31 cases and the importance of the surgical approach. J Pediatr Orthop B. 7(4):286-92, 1998
                                                                                          19. Papagelopoulos PJ et al: Aneurysmal bone cyst of the spine. Management and outcome. Spine. 23(5):621-8, 1998
                                                                                          20. Murphey MD et al: From the archives of the AFIP. Primary tumors of the spine: radiologic pathologic correlation. Radiographics. 16(5):1131-58, 1996
                                                                                          21. Koci TM et al: Aneurysmal bone cyst of the thoracic spine: evolution after particulate embolization. AJNR Am J Neuroradiol. 16(4 Suppl):857-60, 1995
                                                                                          22. Kransdorf MJ et al: Aneurysmal bone cyst: concept, controversy, clinical presentation, and imaging. AJR Am J Roentgenol. 164(3):573-80, 1995