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Angioleiomyoma
Eric Walker, MD, MHA, FACR, FACHE; Catherine C. Roberts, MD; Stephanie A. Bernard, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Pathology

        • Clinical Issues

          TERMINOLOGY

          • Synonyms

            • Angiomyoma, vascular leiomyoma, tuberculum dolorosum
          • Definitions

            • Benign, often painful, smooth muscle neoplasm preferentially occurring in dermis or subcutaneous tissues, usually of lower extremity
            • Composed of well-differentiated perivascular smooth muscle cells arranged around numerous vascular channels
            • Morphologic continuum exists between angiomyoma and myopericytoma (perivascular myxoid neoplasm)
            • Angioleiomyomas are thought to be most common variant of cutaneous leiomyomas

          IMAGING

          • General Features

            • Ultrasonographic Findings

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      Selected References

                                      1. Bernett CN et al: Cutaneous leiomyomas. StatPearls, 2021
                                      2. Torres-de la Roche LA et al: Retroperitoneal angioleiomyomatosis. J Obstet Gynaecol India. 71(3):337-41, 2021
                                      3. Matsuyama A: Angioleiomyoma. In Fletcher CDM et al: WHO Classification of Tumours: Soft Tissue and Bone Tumours. 5th ed. IARC Press. 186-7, 2020
                                      4. Klumpp R et al: Angioleiomyoma in the posterior knee: a case report and literature review. Knee. 24(3):675-9, 2017
                                      5. Kransdorf MJ et al: Muscle tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 3rd ed. Lippincott Williams & Wilkins. 361-72, 2014
                                      6. Prasad R et al: Angioleiomyoma of middle finger terminal phalanx-case report and review of literature. J Hand Microsurg. 6(1):45-6, 2014
                                      7. Van Holsbeeck A et al: Angioleiomyoma in the soleus muscle. JBR-BTR. 97(4):245-7, 2014
                                      8. Oiso N et al: Diagnostic usefulness of ultrasonography for plantar angioleiomyoma. Eur J Dermatol. 23(4):568-70, 2013
                                      9. Park HJ et al: Sonographic appearances of soft tissue angioleiomyomas: differences from other circumscribed soft tissue hypervascular tumors. J Ultrasound Med. 31(10):1589-95, 2012
                                      10. Yoo HJ et al: Angioleiomyoma in soft tissue of extremities: MRI findings. AJR Am J Roentgenol. 192(6):W291-4, 2009
                                      11. Gupte C et al: Angioleiomyoma: magnetic resonance imaging features in ten cases. Skeletal Radiol. 37(11):1003-9, 2008
                                      12. Weiss SW et al: Benign tumors of smooth muscles. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Elsevier. 520-2, 2008
                                      13. Hashimoto H et al: Angioleiomyoma. In Fletcher CDM et al: WHO Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. IARC Press. 128-9, 2002
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Pathology

                                            • Clinical Issues

                                              TERMINOLOGY

                                              • Synonyms

                                                • Angiomyoma, vascular leiomyoma, tuberculum dolorosum
                                              • Definitions

                                                • Benign, often painful, smooth muscle neoplasm preferentially occurring in dermis or subcutaneous tissues, usually of lower extremity
                                                • Composed of well-differentiated perivascular smooth muscle cells arranged around numerous vascular channels
                                                • Morphologic continuum exists between angiomyoma and myopericytoma (perivascular myxoid neoplasm)
                                                • Angioleiomyomas are thought to be most common variant of cutaneous leiomyomas

                                              IMAGING

                                              • General Features

                                                • Ultrasonographic Findings

                                                  • Radiographic Findings

                                                    • CT Findings

                                                      • MR Findings

                                                        • Imaging Recommendations

                                                          DIFFERENTIAL DIAGNOSIS

                                                            PATHOLOGY

                                                            • General Features

                                                              • Gross Pathologic & Surgical Features

                                                                • Microscopic Features

                                                                  CLINICAL ISSUES

                                                                  • Presentation

                                                                    • Demographics

                                                                      • Natural History & Prognosis

                                                                        • Treatment

                                                                          Selected References

                                                                          1. Bernett CN et al: Cutaneous leiomyomas. StatPearls, 2021
                                                                          2. Torres-de la Roche LA et al: Retroperitoneal angioleiomyomatosis. J Obstet Gynaecol India. 71(3):337-41, 2021
                                                                          3. Matsuyama A: Angioleiomyoma. In Fletcher CDM et al: WHO Classification of Tumours: Soft Tissue and Bone Tumours. 5th ed. IARC Press. 186-7, 2020
                                                                          4. Klumpp R et al: Angioleiomyoma in the posterior knee: a case report and literature review. Knee. 24(3):675-9, 2017
                                                                          5. Kransdorf MJ et al: Muscle tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 3rd ed. Lippincott Williams & Wilkins. 361-72, 2014
                                                                          6. Prasad R et al: Angioleiomyoma of middle finger terminal phalanx-case report and review of literature. J Hand Microsurg. 6(1):45-6, 2014
                                                                          7. Van Holsbeeck A et al: Angioleiomyoma in the soleus muscle. JBR-BTR. 97(4):245-7, 2014
                                                                          8. Oiso N et al: Diagnostic usefulness of ultrasonography for plantar angioleiomyoma. Eur J Dermatol. 23(4):568-70, 2013
                                                                          9. Park HJ et al: Sonographic appearances of soft tissue angioleiomyomas: differences from other circumscribed soft tissue hypervascular tumors. J Ultrasound Med. 31(10):1589-95, 2012
                                                                          10. Yoo HJ et al: Angioleiomyoma in soft tissue of extremities: MRI findings. AJR Am J Roentgenol. 192(6):W291-4, 2009
                                                                          11. Gupte C et al: Angioleiomyoma: magnetic resonance imaging features in ten cases. Skeletal Radiol. 37(11):1003-9, 2008
                                                                          12. Weiss SW et al: Benign tumors of smooth muscles. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Elsevier. 520-2, 2008
                                                                          13. Hashimoto H et al: Angioleiomyoma. In Fletcher CDM et al: WHO Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. IARC Press. 128-9, 2002