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Angiomatoid Fibrous Histiocytoma
Stephanie A. Bernard, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          TERMINOLOGY

          • Abbreviations

            • Angiomatoid fibrous histiocytoma (AFH)
          • Synonyms

            • Angiomatoid malignant fibrous histiocytoma
          • Definitions

            • Soft tissue tumor of uncertain differentiation with intermediate biologic potential that rarely metastasizes

          IMAGING

          • General Features

            • Radiographic Findings

              • CT Findings

                • MR Findings

                  • Ultrasonographic Findings

                    • Nuclear Medicine Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Staging, Grading, & Classification

                              • Gross Pathologic & Surgical Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          • Image Interpretation Pearls

                                            • Reporting Tips

                                              Selected References

                                              1. Khader M et al: Angiomatoid fibrous histiocytoma (AFH) unusual clinical presentation and unique radiological findings. BJR Case Rep. 7(2):20190069, 2021
                                              2. Antonescu CR et al: Angiomatoid fibrous histiocytoma. In Fletcher CDM et al: World Health Organization Classification of Tumours: Soft Tissue and Bone Tumours. 5th ed. IARC Press. 271, 2020
                                              3. Colangeli M et al: Difficult diagnosis of angiomatoid fibrous histiocytoma of the leg mimicking a benign condition. J Radiol Case Rep. 13(4):38-45, 2019
                                              4. Martinez SJ et al: Angiomatoid fibrous histiocytoma: novel MR imaging findings. Skeletal Radiol. 45(5):661-70, 2016
                                              5. Chen G et al: Angiomatoid fibrous histiocytoma: unusual sites and unusual morphology. Mod Pathol. 24(12):1560-70, 2011
                                              6. Laffan EE et al: Pediatric soft-tissue tumors and pseudotumors: MR imaging features with pathologic correlation: part 2. Tumors of fibroblastic/myofibroblastic, so-called fibrohistiocytic, muscular, lymphomatous, neurogenic, hair matrix, and uncertain origin. Radiographics. 29(4):e36, 2009
                                              7. Li CS et al: MRI of angiomatoid fibrous histiocytoma. Skeletal Radiol. 33(10):604-8, 2004
                                              8. Fanburg-Smith JM et al: Angiomatoid "malignant" fibrous histiocytoma: a clinicopathologic study of 158 cases and further exploration of the myoid phenotype. Hum Pathol. 30(11):1336-43, 1999
                                              9. Murphey MD et al. Musculoskeletal malignant fibrous histiocytoma: radiologic-pathologic correlation. RadioGraphics 14:807-26; 1994
                                              10. Costa MJ et al: Angiomatoid malignant fibrous histiocytoma. A follow-up study of 108 cases with evaluation of possible histologic predictors of outcome. Am J Surg Pathol. 14(12):1126-32, 1990
                                              Related Anatomy
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                                              Related Differential Diagnoses
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                                              References
                                              Tables

                                              Tables

                                              KEY FACTS

                                              • Terminology

                                                • Imaging

                                                  • Top Differential Diagnoses

                                                    • Clinical Issues

                                                      TERMINOLOGY

                                                      • Abbreviations

                                                        • Angiomatoid fibrous histiocytoma (AFH)
                                                      • Synonyms

                                                        • Angiomatoid malignant fibrous histiocytoma
                                                      • Definitions

                                                        • Soft tissue tumor of uncertain differentiation with intermediate biologic potential that rarely metastasizes

                                                      IMAGING

                                                      • General Features

                                                        • Radiographic Findings

                                                          • CT Findings

                                                            • MR Findings

                                                              • Ultrasonographic Findings

                                                                • Nuclear Medicine Findings

                                                                  • Imaging Recommendations

                                                                    DIFFERENTIAL DIAGNOSIS

                                                                      PATHOLOGY

                                                                      • General Features

                                                                        • Staging, Grading, & Classification

                                                                          • Gross Pathologic & Surgical Features

                                                                            CLINICAL ISSUES

                                                                            • Presentation

                                                                              • Demographics

                                                                                • Natural History & Prognosis

                                                                                  • Treatment

                                                                                    DIAGNOSTIC CHECKLIST

                                                                                    • Consider

                                                                                      • Image Interpretation Pearls

                                                                                        • Reporting Tips

                                                                                          Selected References

                                                                                          1. Khader M et al: Angiomatoid fibrous histiocytoma (AFH) unusual clinical presentation and unique radiological findings. BJR Case Rep. 7(2):20190069, 2021
                                                                                          2. Antonescu CR et al: Angiomatoid fibrous histiocytoma. In Fletcher CDM et al: World Health Organization Classification of Tumours: Soft Tissue and Bone Tumours. 5th ed. IARC Press. 271, 2020
                                                                                          3. Colangeli M et al: Difficult diagnosis of angiomatoid fibrous histiocytoma of the leg mimicking a benign condition. J Radiol Case Rep. 13(4):38-45, 2019
                                                                                          4. Martinez SJ et al: Angiomatoid fibrous histiocytoma: novel MR imaging findings. Skeletal Radiol. 45(5):661-70, 2016
                                                                                          5. Chen G et al: Angiomatoid fibrous histiocytoma: unusual sites and unusual morphology. Mod Pathol. 24(12):1560-70, 2011
                                                                                          6. Laffan EE et al: Pediatric soft-tissue tumors and pseudotumors: MR imaging features with pathologic correlation: part 2. Tumors of fibroblastic/myofibroblastic, so-called fibrohistiocytic, muscular, lymphomatous, neurogenic, hair matrix, and uncertain origin. Radiographics. 29(4):e36, 2009
                                                                                          7. Li CS et al: MRI of angiomatoid fibrous histiocytoma. Skeletal Radiol. 33(10):604-8, 2004
                                                                                          8. Fanburg-Smith JM et al: Angiomatoid "malignant" fibrous histiocytoma: a clinicopathologic study of 158 cases and further exploration of the myoid phenotype. Hum Pathol. 30(11):1336-43, 1999
                                                                                          9. Murphey MD et al. Musculoskeletal malignant fibrous histiocytoma: radiologic-pathologic correlation. RadioGraphics 14:807-26; 1994
                                                                                          10. Costa MJ et al: Angiomatoid malignant fibrous histiocytoma. A follow-up study of 108 cases with evaluation of possible histologic predictors of outcome. Am J Surg Pathol. 14(12):1126-32, 1990