May occur next to implants (synthetic grafts) or sites of prior trauma
85% have no identifiable risk factor
IMAGING
General Features
CT Findings
MR Findings
Nuclear Medicine Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
Selected References
Weidema ME et al: Targeting angiosarcomas of the soft tissues: a challenging effort in a heterogeneous and rare disease. Crit Rev Oncol Hematol. 138:120-31, 2019
Gaballah AH et al: Angiosarcoma: clinical and imaging features from head to toe. Br J Radiol. 90(1075):20170039, 2017
Chen YR et al: Distant metastases in a young woman with Stewart-Treves syndrome demonstrated by an FDG-PET/CT scan. Clin Nucl Med. 39(11):975-6, 2014
Lee R et al: Lymphedema-related angiogenic tumors and other malignancies. Clin Dermatol. 32(5):616-20, 2014
Tenjarla S et al: Cutaneous angiosarcoma of the foot: a case report and review of the literature. Case Rep Oncol Med. 2014:657876, 2014
Young RJ et al: Angiogenic growth factor expression in benign and malignant vascular tumours. Exp Mol Pathol. 97(1):148-53, 2014
Cox CA et al: Angiosarcoma presenting with minor erythema and swelling. Case Rep Ophthalmol. 4(1):59-63, 2013
Fisher C: Unusual myoid, perivascular, and postradiation lesions, with emphasis on atypical vascular lesion, postradiation cutaneous angiosarcoma, myoepithelial tumors, myopericytoma, and perivascular epithelioid cell tumor. Semin Diagn Pathol. 30(1):73-84, 2013
Sharma P et al: Detection of recurrent cutaneous angiosarcoma of lower extremity with (18)f-fluorodeoxyglucose positron emission tomography-computed tomography: report of three cases. Indian J Dermatol. 58(3):242, 2013
Mentzel T et al: Postradiation cutaneous angiosarcoma after treatment of breast carcinoma is characterized by MYC amplification in contrast to atypical vascular lesions after radiotherapy and control cases: clinicopathological, immunohistochemical and molecular analysis of 66 cases. Mod Pathol. 25(1):75-85, 2012
Chen Y et al: Epithelioid angiosarcoma of bone and soft tissue: a report of seven cases with emphasis on morphologic diversity, immunohistochemical features and clinical outcome. Tumori. 97(5):585-9, 2011
Hart J et al: Epithelioid angiosarcoma: a brief diagnostic review and differential diagnosis. Arch Pathol Lab Med. 135(2):268-72, 2011
Mentzel T: Sarcomas of the skin in the elderly. Clin Dermatol. 29(1):80-90, 2011
Sakemi M et al: A case of postirradiation angiosarcoma of the greater omentum with hemorrhage. Clin J Gastroenterol. 4(5):302-6, 2011
Suchak R et al: Primary cutaneous epithelioid angiosarcoma: a clinicopathologic study of 13 cases of a rare neoplasm occurring outside the setting of conventional angiosarcomas and with predilection for the limbs. Am J Surg Pathol. 35(1):60-9, 2011
Tokmak E et al: F18-FDG PET/CT scanning in angiosarcoma: report of two cases. Mol Imaging Radionucl Ther. 20(2):63-6, 2011
Moukaddam H et al: MRI characteristics and classification of peripheral vascular malformations and tumors. Skeletal Radiol. 38(6):535-47, 2009
Weiss SW et al: Malignant vascular tumors. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Elsevier. 703-19, 2008
Kransdorf MJ et al: Vascular and lymphatic tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 2nd ed. Lippincott Williams & Wilkins. 177-88, 2006
Weiss SW et al: Angiosarcoma of soft tissue. In Fletcher CDM et al: WHO Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. IARC Press. 175-7, 2002
Murphey MD et al: From the archives of the AFIP. Musculoskeletal angiomatous lesions: radiologic-pathologic correlation. Radiographics. 15(4):893-917, 1995
May occur next to implants (synthetic grafts) or sites of prior trauma
85% have no identifiable risk factor
IMAGING
General Features
CT Findings
MR Findings
Nuclear Medicine Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
Selected References
Weidema ME et al: Targeting angiosarcomas of the soft tissues: a challenging effort in a heterogeneous and rare disease. Crit Rev Oncol Hematol. 138:120-31, 2019
Gaballah AH et al: Angiosarcoma: clinical and imaging features from head to toe. Br J Radiol. 90(1075):20170039, 2017
Chen YR et al: Distant metastases in a young woman with Stewart-Treves syndrome demonstrated by an FDG-PET/CT scan. Clin Nucl Med. 39(11):975-6, 2014
Lee R et al: Lymphedema-related angiogenic tumors and other malignancies. Clin Dermatol. 32(5):616-20, 2014
Tenjarla S et al: Cutaneous angiosarcoma of the foot: a case report and review of the literature. Case Rep Oncol Med. 2014:657876, 2014
Young RJ et al: Angiogenic growth factor expression in benign and malignant vascular tumours. Exp Mol Pathol. 97(1):148-53, 2014
Cox CA et al: Angiosarcoma presenting with minor erythema and swelling. Case Rep Ophthalmol. 4(1):59-63, 2013
Fisher C: Unusual myoid, perivascular, and postradiation lesions, with emphasis on atypical vascular lesion, postradiation cutaneous angiosarcoma, myoepithelial tumors, myopericytoma, and perivascular epithelioid cell tumor. Semin Diagn Pathol. 30(1):73-84, 2013
Sharma P et al: Detection of recurrent cutaneous angiosarcoma of lower extremity with (18)f-fluorodeoxyglucose positron emission tomography-computed tomography: report of three cases. Indian J Dermatol. 58(3):242, 2013
Mentzel T et al: Postradiation cutaneous angiosarcoma after treatment of breast carcinoma is characterized by MYC amplification in contrast to atypical vascular lesions after radiotherapy and control cases: clinicopathological, immunohistochemical and molecular analysis of 66 cases. Mod Pathol. 25(1):75-85, 2012
Chen Y et al: Epithelioid angiosarcoma of bone and soft tissue: a report of seven cases with emphasis on morphologic diversity, immunohistochemical features and clinical outcome. Tumori. 97(5):585-9, 2011
Hart J et al: Epithelioid angiosarcoma: a brief diagnostic review and differential diagnosis. Arch Pathol Lab Med. 135(2):268-72, 2011
Mentzel T: Sarcomas of the skin in the elderly. Clin Dermatol. 29(1):80-90, 2011
Sakemi M et al: A case of postirradiation angiosarcoma of the greater omentum with hemorrhage. Clin J Gastroenterol. 4(5):302-6, 2011
Suchak R et al: Primary cutaneous epithelioid angiosarcoma: a clinicopathologic study of 13 cases of a rare neoplasm occurring outside the setting of conventional angiosarcomas and with predilection for the limbs. Am J Surg Pathol. 35(1):60-9, 2011
Tokmak E et al: F18-FDG PET/CT scanning in angiosarcoma: report of two cases. Mol Imaging Radionucl Ther. 20(2):63-6, 2011
Moukaddam H et al: MRI characteristics and classification of peripheral vascular malformations and tumors. Skeletal Radiol. 38(6):535-47, 2009
Weiss SW et al: Malignant vascular tumors. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Elsevier. 703-19, 2008
Kransdorf MJ et al: Vascular and lymphatic tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 2nd ed. Lippincott Williams & Wilkins. 177-88, 2006
Weiss SW et al: Angiosarcoma of soft tissue. In Fletcher CDM et al: WHO Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. IARC Press. 175-7, 2002
Murphey MD et al: From the archives of the AFIP. Musculoskeletal angiomatous lesions: radiologic-pathologic correlation. Radiographics. 15(4):893-917, 1995
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