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Angiosarcoma: Soft Tissue
B.J. Manaster, MD, PhD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Clinical Issues

        TERMINOLOGY

        • Synonyms

          • Hemangiosarcoma, malignant hemangioendothelioma, lymphangiosarcoma, hemangioblastoma, malignant angioendothelioma
        • Definitions

          • Malignant endothelial neoplasm with exceptionally poor prognosis

        IMAGING

        • General Features

          • CT Findings

            • MR Findings

              • Nuclear Medicine Findings

                DIFFERENTIAL DIAGNOSIS

                  PATHOLOGY

                  • General Features

                    • Gross Pathologic & Surgical Features

                      • Microscopic Features

                        CLINICAL ISSUES

                        • Presentation

                          • Demographics

                            • Natural History & Prognosis

                              • Treatment

                                Selected References

                                1. Chen YR et al: Distant metastases in a young woman with Stewart-Treves syndrome demonstrated by an FDG-PET/CT scan. Clin Nucl Med. 39(11):975-6, 2014
                                2. Lee R et al: Lymphedema-related angiogenic tumors and other malignancies. Clin Dermatol. 32(5):616-20, 2014
                                3. Young RJ et al: Angiogenic growth factor expression in benign and malignant vascular tumours. Exp Mol Pathol. 97(1):148-53, 2014
                                4. Cox CA et al: Angiosarcoma presenting with minor erythema and swelling. Case Rep Ophthalmol. 4(1):59-63, 2013
                                5. Fisher C: Unusual myoid, perivascular, and postradiation lesions, with emphasis on atypical vascular lesion, postradiation cutaneous angiosarcoma, myoepithelial tumors, myopericytoma, and perivascular epithelioid cell tumor. Semin Diagn Pathol. 30(1):73-84, 2013
                                6. Sharma P et al: Detection of recurrent cutaneous angiosarcoma of lower extremity with (18)f-fluorodeoxyglucose positron emission tomography-computed tomography: report of three cases. Indian J Dermatol. 58(3):242, 2013
                                7. Mentzel T et al: Postradiation cutaneous angiosarcoma after treatment of breast carcinoma is characterized by MYC amplification in contrast to atypical vascular lesions after radiotherapy and control cases: clinicopathological, immunohistochemical and molecular analysis of 66 cases. Mod Pathol. 25(1):75-85, 2012
                                8. Chen Y et al: Epithelioid angiosarcoma of bone and soft tissue: a report of seven cases with emphasis on morphologic diversity, immunohistochemical features and clinical outcome. Tumori. 97(5):585-9, 2011
                                9. Hart J et al: Epithelioid angiosarcoma: a brief diagnostic review and differential diagnosis. Arch Pathol Lab Med. 135(2):268-72, 2011
                                10. Mentzel T: Sarcomas of the skin in the elderly. Clin Dermatol. 29(1):80-90, 2011
                                11. Sakemi M et al: A case of postirradiation angiosarcoma of the greater omentum with hemorrhage. Clin J Gastroenterol. 4(5):302-6, 2011
                                12. Suchak R et al: Primary cutaneous epithelioid angiosarcoma: a clinicopathologic study of 13 cases of a rare neoplasm occurring outside the setting of conventional angiosarcomas and with predilection for the limbs. Am J Surg Pathol. 35(1):60-9, 2011
                                13. Tokmak E et al: F18-FDG PET/CT scanning in angiosarcoma: report of two cases. Mol Imaging Radionucl Ther. 20(2):63-6, 2011
                                14. Moukaddam H et al: MRI characteristics and classification of peripheral vascular malformations and tumors. Skeletal Radiol. 38(6):535-47, 2009
                                15. Weiss SW et al: Malignant vascular tumors. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Philadelphia: Elsevier. 703-19, 2008
                                16. Kransdorf MJ et al: Vascular and lymphatic tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 2nd ed. Philadelphia: Lippincott Williams & Wilkins. 177-188, 2006
                                17. Weiss SW et al: Angiosarcoma of soft tissue. In Fletcher CDM et al: World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. Lyon: IARC Press. 175-7, 2002
                                18. Murphey MD et al: From the archives of the AFIP. Musculoskeletal angiomatous lesions: radiologic-pathologic correlation. Radiographics. 15(4):893-917, 1995
                                Related Anatomy
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                                Related Differential Diagnoses
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                                References
                                Tables

                                Tables

                                KEY FACTS

                                • Terminology

                                  • Imaging

                                    • Clinical Issues

                                      TERMINOLOGY

                                      • Synonyms

                                        • Hemangiosarcoma, malignant hemangioendothelioma, lymphangiosarcoma, hemangioblastoma, malignant angioendothelioma
                                      • Definitions

                                        • Malignant endothelial neoplasm with exceptionally poor prognosis

                                      IMAGING

                                      • General Features

                                        • CT Findings

                                          • MR Findings

                                            • Nuclear Medicine Findings

                                              DIFFERENTIAL DIAGNOSIS

                                                PATHOLOGY

                                                • General Features

                                                  • Gross Pathologic & Surgical Features

                                                    • Microscopic Features

                                                      CLINICAL ISSUES

                                                      • Presentation

                                                        • Demographics

                                                          • Natural History & Prognosis

                                                            • Treatment

                                                              Selected References

                                                              1. Chen YR et al: Distant metastases in a young woman with Stewart-Treves syndrome demonstrated by an FDG-PET/CT scan. Clin Nucl Med. 39(11):975-6, 2014
                                                              2. Lee R et al: Lymphedema-related angiogenic tumors and other malignancies. Clin Dermatol. 32(5):616-20, 2014
                                                              3. Young RJ et al: Angiogenic growth factor expression in benign and malignant vascular tumours. Exp Mol Pathol. 97(1):148-53, 2014
                                                              4. Cox CA et al: Angiosarcoma presenting with minor erythema and swelling. Case Rep Ophthalmol. 4(1):59-63, 2013
                                                              5. Fisher C: Unusual myoid, perivascular, and postradiation lesions, with emphasis on atypical vascular lesion, postradiation cutaneous angiosarcoma, myoepithelial tumors, myopericytoma, and perivascular epithelioid cell tumor. Semin Diagn Pathol. 30(1):73-84, 2013
                                                              6. Sharma P et al: Detection of recurrent cutaneous angiosarcoma of lower extremity with (18)f-fluorodeoxyglucose positron emission tomography-computed tomography: report of three cases. Indian J Dermatol. 58(3):242, 2013
                                                              7. Mentzel T et al: Postradiation cutaneous angiosarcoma after treatment of breast carcinoma is characterized by MYC amplification in contrast to atypical vascular lesions after radiotherapy and control cases: clinicopathological, immunohistochemical and molecular analysis of 66 cases. Mod Pathol. 25(1):75-85, 2012
                                                              8. Chen Y et al: Epithelioid angiosarcoma of bone and soft tissue: a report of seven cases with emphasis on morphologic diversity, immunohistochemical features and clinical outcome. Tumori. 97(5):585-9, 2011
                                                              9. Hart J et al: Epithelioid angiosarcoma: a brief diagnostic review and differential diagnosis. Arch Pathol Lab Med. 135(2):268-72, 2011
                                                              10. Mentzel T: Sarcomas of the skin in the elderly. Clin Dermatol. 29(1):80-90, 2011
                                                              11. Sakemi M et al: A case of postirradiation angiosarcoma of the greater omentum with hemorrhage. Clin J Gastroenterol. 4(5):302-6, 2011
                                                              12. Suchak R et al: Primary cutaneous epithelioid angiosarcoma: a clinicopathologic study of 13 cases of a rare neoplasm occurring outside the setting of conventional angiosarcomas and with predilection for the limbs. Am J Surg Pathol. 35(1):60-9, 2011
                                                              13. Tokmak E et al: F18-FDG PET/CT scanning in angiosarcoma: report of two cases. Mol Imaging Radionucl Ther. 20(2):63-6, 2011
                                                              14. Moukaddam H et al: MRI characteristics and classification of peripheral vascular malformations and tumors. Skeletal Radiol. 38(6):535-47, 2009
                                                              15. Weiss SW et al: Malignant vascular tumors. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Philadelphia: Elsevier. 703-19, 2008
                                                              16. Kransdorf MJ et al: Vascular and lymphatic tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 2nd ed. Philadelphia: Lippincott Williams & Wilkins. 177-188, 2006
                                                              17. Weiss SW et al: Angiosarcoma of soft tissue. In Fletcher CDM et al: World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. Lyon: IARC Press. 175-7, 2002
                                                              18. Murphey MD et al: From the archives of the AFIP. Musculoskeletal angiomatous lesions: radiologic-pathologic correlation. Radiographics. 15(4):893-917, 1995