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Ankylosing Spondylitis
Tyler H. Ternes, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          TERMINOLOGY

          • Abbreviations

            • Ankylosing spondylitis (AS)
          • Synonyms

            • Bechterew disease
            • Radiographic axial spondyloarthritis (r-axSpA)
          • Definitions

            • Chronic multisystem inflammatory disorder with articular and extraarticular manifestations
              • Predilection for axial skeleton
              • Extraarticular thoracic manifestations
                • Pleuropulmonary disease
                • Cardiovascular involvement
            • r-axSpA (AS)
              • Definite sacroiliitis on radiographs
            • Nonradiographic axial spondyloarthritis
              • Clinical diagnosis, absence of radiographic manifestations, possible sacroiliitis on MR
              • May eventually evolve to AS

          IMAGING

          • General Features

            • Radiographic Findings

              • CT Findings

                • MR Findings

                  • Echocardiographic Findings

                    • Nuclear Medicine Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Staging, Grading, & Classification

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      Selected References

                                      1. Hotta M et al: Fluorodeoxyglucose PET/CT of arthritis in rheumatic diseases: a pictorial review. Radiographics. 40(1):223-40, 2020
                                      2. Magrey MN et al: Recognizing axial spondyloarthritis: a guide for primary care. Mayo Clin Proc. 95(11):2499-508, 2020
                                      3. Danve A: Thoracic Manifestations of ankylosing spondylitis, inflammatory bowel disease, and relapsing polychondritis. Clin Chest Med. 40(3):599-608, 2019
                                      4. Chang EY et al: Adult inflammatory arthritides: what the radiologist should know. Radiographics. 36(6):1849-70, 2016
                                      5. Taurog JD et al: Ankylosing spondylitis and axial spondyloarthritis. N Engl J Med. 374(26):2563-74, 2016
                                      6. Marquette D et al: Chronic bronchiolitis in ankylosing spondylitis. Sarcoidosis Vasc Diffuse Lung Dis. 30(3):231-6, 2013
                                      7. Kanathur N et al: Pulmonary manifestations of ankylosing spondylitis. Clin Chest Med. 31(3):547-54, 2010
                                      8. Kang J et al: Manifestations of systemic diseases on thoracic imaging. Curr Probl Diagn Radiol. 39(6):247-61, 2010
                                      9. Lynch DA: Lung disease related to collagen vascular disease. J Thorac Imaging. 24(4):299-309, 2009
                                      10. El Maghraoui A et al: Lung findings on thoracic high-resolution computed tomography in patients with ankylosing spondylitis. Correlations with disease duration, clinical findings and pulmonary function testing. Clin Rheumatol. 23(2):123-8, 2004
                                      11. Souza AS Jr et al: Pulmonary abnormalities in ankylosing spondylitis: inspiratory and expiratory high-resolution CT findings in 17 patients. J Thorac Imaging. 19(4):259-63, 2004
                                      12. Fenlon HM et al: Plain radiographs and thoracic high-resolution CT in patients with ankylosing spondylitis. AJR 168: 1067-72, 1997
                                      13. Rosenow E et al: Pleuropulmonary manifestations of ankylosing spondylitis. Mayo Clin Proc 52:641-9, 1977
                                      Related Anatomy
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                                      Related Differential Diagnoses
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                                      References
                                      Tables

                                      Tables

                                      KEY FACTS

                                      • Terminology

                                        • Imaging

                                          • Top Differential Diagnoses

                                            • Clinical Issues

                                              TERMINOLOGY

                                              • Abbreviations

                                                • Ankylosing spondylitis (AS)
                                              • Synonyms

                                                • Bechterew disease
                                                • Radiographic axial spondyloarthritis (r-axSpA)
                                              • Definitions

                                                • Chronic multisystem inflammatory disorder with articular and extraarticular manifestations
                                                  • Predilection for axial skeleton
                                                  • Extraarticular thoracic manifestations
                                                    • Pleuropulmonary disease
                                                    • Cardiovascular involvement
                                                • r-axSpA (AS)
                                                  • Definite sacroiliitis on radiographs
                                                • Nonradiographic axial spondyloarthritis
                                                  • Clinical diagnosis, absence of radiographic manifestations, possible sacroiliitis on MR
                                                  • May eventually evolve to AS

                                              IMAGING

                                              • General Features

                                                • Radiographic Findings

                                                  • CT Findings

                                                    • MR Findings

                                                      • Echocardiographic Findings

                                                        • Nuclear Medicine Findings

                                                          • Imaging Recommendations

                                                            DIFFERENTIAL DIAGNOSIS

                                                              PATHOLOGY

                                                              • General Features

                                                                • Staging, Grading, & Classification

                                                                  CLINICAL ISSUES

                                                                  • Presentation

                                                                    • Demographics

                                                                      • Natural History & Prognosis

                                                                        • Treatment

                                                                          Selected References

                                                                          1. Hotta M et al: Fluorodeoxyglucose PET/CT of arthritis in rheumatic diseases: a pictorial review. Radiographics. 40(1):223-40, 2020
                                                                          2. Magrey MN et al: Recognizing axial spondyloarthritis: a guide for primary care. Mayo Clin Proc. 95(11):2499-508, 2020
                                                                          3. Danve A: Thoracic Manifestations of ankylosing spondylitis, inflammatory bowel disease, and relapsing polychondritis. Clin Chest Med. 40(3):599-608, 2019
                                                                          4. Chang EY et al: Adult inflammatory arthritides: what the radiologist should know. Radiographics. 36(6):1849-70, 2016
                                                                          5. Taurog JD et al: Ankylosing spondylitis and axial spondyloarthritis. N Engl J Med. 374(26):2563-74, 2016
                                                                          6. Marquette D et al: Chronic bronchiolitis in ankylosing spondylitis. Sarcoidosis Vasc Diffuse Lung Dis. 30(3):231-6, 2013
                                                                          7. Kanathur N et al: Pulmonary manifestations of ankylosing spondylitis. Clin Chest Med. 31(3):547-54, 2010
                                                                          8. Kang J et al: Manifestations of systemic diseases on thoracic imaging. Curr Probl Diagn Radiol. 39(6):247-61, 2010
                                                                          9. Lynch DA: Lung disease related to collagen vascular disease. J Thorac Imaging. 24(4):299-309, 2009
                                                                          10. El Maghraoui A et al: Lung findings on thoracic high-resolution computed tomography in patients with ankylosing spondylitis. Correlations with disease duration, clinical findings and pulmonary function testing. Clin Rheumatol. 23(2):123-8, 2004
                                                                          11. Souza AS Jr et al: Pulmonary abnormalities in ankylosing spondylitis: inspiratory and expiratory high-resolution CT findings in 17 patients. J Thorac Imaging. 19(4):259-63, 2004
                                                                          12. Fenlon HM et al: Plain radiographs and thoracic high-resolution CT in patients with ankylosing spondylitis. AJR 168: 1067-72, 1997
                                                                          13. Rosenow E et al: Pleuropulmonary manifestations of ankylosing spondylitis. Mayo Clin Proc 52:641-9, 1977