Eating disorder that involves limiting amount of food intake, resulting in starvation
Osteoporosis and its consequent bone fragility
7x ↑ in fracture risk; may persist despite recovery
Greater deficit in bone mineral density if onset of anorexia during adolescence
Reduced muscle mass
Serous atrophy of marrow associated with true starvation
Depletion of both red and yellow marrow elements; extracellular deposition of gelatinous substances
IMAGING
Radiographic Findings
CT Findings
MR Findings
Selected References
Singhal V et al: Suboptimal bone microarchitecure in adolescent girls with obesity compared to normal-weight controls and girls with anorexia nervosa. Bone. 122:246-53, 2019
Ecklund K et al: Bone marrow fat content in 70 adolescent girls with anorexia nervosa: magnetic resonance imaging and magnetic resonance spectroscopy assessment. Pediatr Radiol. 47(8):952-62, 2017
Robinson L et al: Eating disorders and bone metabolism in women. Curr Opin Pediatr. 29(4):488-96, 2017
Tabari A et al: Anorexia nervosa: analysis of trabecular texture with CT. Radiology. 283(1):178-85, 2017
Bachmann KN et al: Vertebral strength and estimated fracture risk across the BMI spectrum in women. J Bone Miner Res. 31(2):281-8, 2016
Veronese N et al: Vitamin D status in anorexia nervosa: a meta-analysis. Int J Eat Disord. 48(7):803-13, 2015
Misra M et al: Anorexia nervosa and bone. J Endocrinol. 221(3):R163-76, 2014
Bowden DJ et al: Radiology of eating disorders: a pictorial review. Radiographics. 33(4):1171-93, 2013
Kraeft JJ et al: Imaging findings in eating disorders. AJR Am J Roentgenol. 200(4):W328-35, 2013
Bredella MA et al: Distal radius in adolescent girls with anorexia nervosa: trabecular structure analysis with high-resolution flat-panel volume CT. Radiology. 249(3):938-46, 2008
Galusca B et al: Constitutional thinness: unusual human phenotype of low bone quality. J Clin Endocrinol Metab. 93(1):110-7, 2008
Polito A et al: Body composition changes in anorexia nervosa. Eur J Clin Nutr. 52(9):655-62, 1998
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References
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KEY FACTS
Terminology
Imaging
Clinical Issues
TERMINOLOGY
Definitions
Eating disorder that involves limiting amount of food intake, resulting in starvation
Osteoporosis and its consequent bone fragility
7x ↑ in fracture risk; may persist despite recovery
Greater deficit in bone mineral density if onset of anorexia during adolescence
Reduced muscle mass
Serous atrophy of marrow associated with true starvation
Depletion of both red and yellow marrow elements; extracellular deposition of gelatinous substances
IMAGING
Radiographic Findings
CT Findings
MR Findings
Selected References
Singhal V et al: Suboptimal bone microarchitecure in adolescent girls with obesity compared to normal-weight controls and girls with anorexia nervosa. Bone. 122:246-53, 2019
Ecklund K et al: Bone marrow fat content in 70 adolescent girls with anorexia nervosa: magnetic resonance imaging and magnetic resonance spectroscopy assessment. Pediatr Radiol. 47(8):952-62, 2017
Robinson L et al: Eating disorders and bone metabolism in women. Curr Opin Pediatr. 29(4):488-96, 2017
Tabari A et al: Anorexia nervosa: analysis of trabecular texture with CT. Radiology. 283(1):178-85, 2017
Bachmann KN et al: Vertebral strength and estimated fracture risk across the BMI spectrum in women. J Bone Miner Res. 31(2):281-8, 2016
Veronese N et al: Vitamin D status in anorexia nervosa: a meta-analysis. Int J Eat Disord. 48(7):803-13, 2015
Misra M et al: Anorexia nervosa and bone. J Endocrinol. 221(3):R163-76, 2014
Bowden DJ et al: Radiology of eating disorders: a pictorial review. Radiographics. 33(4):1171-93, 2013
Kraeft JJ et al: Imaging findings in eating disorders. AJR Am J Roentgenol. 200(4):W328-35, 2013
Bredella MA et al: Distal radius in adolescent girls with anorexia nervosa: trabecular structure analysis with high-resolution flat-panel volume CT. Radiology. 249(3):938-46, 2008
Galusca B et al: Constitutional thinness: unusual human phenotype of low bone quality. J Clin Endocrinol Metab. 93(1):110-7, 2008
Polito A et al: Body composition changes in anorexia nervosa. Eur J Clin Nutr. 52(9):655-62, 1998
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