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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Definitions
- Transient or permanent paraplegia
- Uncommon complication following intrathecal chemotherapy
- Initially described following intrathecal methotrexate (MTX) in pediatric acute lymphoblastic leukemia patients
- Subsequently reported with other chemotherapy agents and in adults
IMAGING
General Features
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Wallis E et al: Avoiding a lumbar puncture may be a rash decision: a case report of varicella-zoster virus-associated radiculopathy in advanced HIV infection. Int J STD AIDS. 30(10):1031-3, 2019
- Whalen AM et al: Sacral myeloradiculitis: an uncommon complication of genital herpes infection. Pediatrics. 144(1), 2019
- Draak TH et al: Changing outcome in inflammatory neuropathies: Rasch-comparative responsiveness. Neurology. 83(23):2124-32, 2014
- Ma YY et al: Guillain-Barré syndrome and severe infection following chemotherapy for peripheral T-cell lymphoma: a case report. Oncol Lett. 8(6):2695-8, 2014
- Endo K et al: [An adult Guillain-Barré syndrome patient with enhancement of anterior roots on spinal MRI and severe radicular pain relieved by intravenous methylprednisolone pulse therapy: a case report.] Rinsho Shinkeigaku. 53(7):543-50, 2013
- Lee HY et al: Irreversible paraplegia following one time prophylactic intrathecal chemotherapy in an adult patient with acute lymphoblastic leukemia. Yonsei Med J. 49(1):151-4, 2008
- Pascual AM et al: Anterior lumbosacral polyradiculopathy after intrathecal administration of methotrexate. J Neurol Sci. 267(1-2):158-61, 2008
- Rison RA: Ascending sensory motor polyradiculoneuropathy with cranial nerve involvement following administration of intrathecal methotrexate and intravenous cytarabine in a patient with acute myelogenous leukemia: a case report*. Cases J. 1(1):255, 2008
- Santos-García D et al: Pure motor lumbosacral radiculopathy after intrathecal chemotherapy. Eur J Neurol. 15(8):e86-7, 2008
- Counsel P et al: Myelopathy due to intrathecal chemotherapy: magnetic resonance imaging findings. Clin Radiol. 62(2):172-6, 2007
- Rolf N et al: Acute ascending motoric paraplegia following intrathecal chemotherapy for treatment of acute lymphoblastic leukemia in children: case reports and review of the literature. Klin Padiatr. 218(6):350-4, 2006
- Bay A et al: Myelopathy due to intrathecal chemotherapy: report of six cases. J Pediatr Hematol Oncol. 27(5):270-2, 2005
- Umeda M et al: [Gadolinium enhancement of the anterior portion of the lumbosacral roots in a case of post-irradiation lumbosacral radiculopathy.] Rinsho Shinkeigaku. 45(10):758-61, 2005
- Anderson SC et al: Ventral polyradiculopathy with pediatric acute lymphocytic leukemia. Muscle Nerve. 25(1):106-10, 2002
- Koh S et al: Anterior lumbosacral radiculopathy after intrathecal methotrexate treatment. Pediatr Neurol. 21(2):576-8, 1999
- Vainionpää L et al: Chemotherapy for acute lymphoblastic leukemia may cause subtle changes of the spinal cord detectable by somatosensory evoked potentials. Med Pediatr Oncol. 28(1):41-7, 1997
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Definitions
- Transient or permanent paraplegia
- Uncommon complication following intrathecal chemotherapy
- Initially described following intrathecal methotrexate (MTX) in pediatric acute lymphoblastic leukemia patients
- Subsequently reported with other chemotherapy agents and in adults
IMAGING
General Features
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Wallis E et al: Avoiding a lumbar puncture may be a rash decision: a case report of varicella-zoster virus-associated radiculopathy in advanced HIV infection. Int J STD AIDS. 30(10):1031-3, 2019
- Whalen AM et al: Sacral myeloradiculitis: an uncommon complication of genital herpes infection. Pediatrics. 144(1), 2019
- Draak TH et al: Changing outcome in inflammatory neuropathies: Rasch-comparative responsiveness. Neurology. 83(23):2124-32, 2014
- Ma YY et al: Guillain-Barré syndrome and severe infection following chemotherapy for peripheral T-cell lymphoma: a case report. Oncol Lett. 8(6):2695-8, 2014
- Endo K et al: [An adult Guillain-Barré syndrome patient with enhancement of anterior roots on spinal MRI and severe radicular pain relieved by intravenous methylprednisolone pulse therapy: a case report.] Rinsho Shinkeigaku. 53(7):543-50, 2013
- Lee HY et al: Irreversible paraplegia following one time prophylactic intrathecal chemotherapy in an adult patient with acute lymphoblastic leukemia. Yonsei Med J. 49(1):151-4, 2008
- Pascual AM et al: Anterior lumbosacral polyradiculopathy after intrathecal administration of methotrexate. J Neurol Sci. 267(1-2):158-61, 2008
- Rison RA: Ascending sensory motor polyradiculoneuropathy with cranial nerve involvement following administration of intrathecal methotrexate and intravenous cytarabine in a patient with acute myelogenous leukemia: a case report*. Cases J. 1(1):255, 2008
- Santos-García D et al: Pure motor lumbosacral radiculopathy after intrathecal chemotherapy. Eur J Neurol. 15(8):e86-7, 2008
- Counsel P et al: Myelopathy due to intrathecal chemotherapy: magnetic resonance imaging findings. Clin Radiol. 62(2):172-6, 2007
- Rolf N et al: Acute ascending motoric paraplegia following intrathecal chemotherapy for treatment of acute lymphoblastic leukemia in children: case reports and review of the literature. Klin Padiatr. 218(6):350-4, 2006
- Bay A et al: Myelopathy due to intrathecal chemotherapy: report of six cases. J Pediatr Hematol Oncol. 27(5):270-2, 2005
- Umeda M et al: [Gadolinium enhancement of the anterior portion of the lumbosacral roots in a case of post-irradiation lumbosacral radiculopathy.] Rinsho Shinkeigaku. 45(10):758-61, 2005
- Anderson SC et al: Ventral polyradiculopathy with pediatric acute lymphocytic leukemia. Muscle Nerve. 25(1):106-10, 2002
- Koh S et al: Anterior lumbosacral radiculopathy after intrathecal methotrexate treatment. Pediatr Neurol. 21(2):576-8, 1999
- Vainionpää L et al: Chemotherapy for acute lymphoblastic leukemia may cause subtle changes of the spinal cord detectable by somatosensory evoked potentials. Med Pediatr Oncol. 28(1):41-7, 1997
