Uncommon complication following intrathecal chemotherapy
Initially described following intrathecal methotrexate (MTX) in pediatric acute lymphoblastic leukemia patients
Subsequently reported with other chemotherapy agents and in adults
IMAGING
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MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Wallis E et al: Avoiding a lumbar puncture may be a rash decision: a case report of varicella-zoster virus-associated radiculopathy in advanced HIV infection. Int J STD AIDS. 30(10):1031-3, 2019
Whalen AM et al: Sacral myeloradiculitis: an uncommon complication of genital herpes infection. Pediatrics. 144(1), 2019
Draak TH et al: Changing outcome in inflammatory neuropathies: Rasch-comparative responsiveness. Neurology. 83(23):2124-32, 2014
Ma YY et al: Guillain-Barré syndrome and severe infection following chemotherapy for peripheral T-cell lymphoma: a case report. Oncol Lett. 8(6):2695-8, 2014
Endo K et al: [An adult Guillain-Barré syndrome patient with enhancement of anterior roots on spinal MRI and severe radicular pain relieved by intravenous methylprednisolone pulse therapy: a case report.] Rinsho Shinkeigaku. 53(7):543-50, 2013
Lee HY et al: Irreversible paraplegia following one time prophylactic intrathecal chemotherapy in an adult patient with acute lymphoblastic leukemia. Yonsei Med J. 49(1):151-4, 2008
Pascual AM et al: Anterior lumbosacral polyradiculopathy after intrathecal administration of methotrexate. J Neurol Sci. 267(1-2):158-61, 2008
Rison RA: Ascending sensory motor polyradiculoneuropathy with cranial nerve involvement following administration of intrathecal methotrexate and intravenous cytarabine in a patient with acute myelogenous leukemia: a case report*. Cases J. 1(1):255, 2008
Santos-García D et al: Pure motor lumbosacral radiculopathy after intrathecal chemotherapy. Eur J Neurol. 15(8):e86-7, 2008
Counsel P et al: Myelopathy due to intrathecal chemotherapy: magnetic resonance imaging findings. Clin Radiol. 62(2):172-6, 2007
Rolf N et al: Acute ascending motoric paraplegia following intrathecal chemotherapy for treatment of acute lymphoblastic leukemia in children: case reports and review of the literature. Klin Padiatr. 218(6):350-4, 2006
Bay A et al: Myelopathy due to intrathecal chemotherapy: report of six cases. J Pediatr Hematol Oncol. 27(5):270-2, 2005
Umeda M et al: [Gadolinium enhancement of the anterior portion of the lumbosacral roots in a case of post-irradiation lumbosacral radiculopathy.] Rinsho Shinkeigaku. 45(10):758-61, 2005
Anderson SC et al: Ventral polyradiculopathy with pediatric acute lymphocytic leukemia. Muscle Nerve. 25(1):106-10, 2002
Koh S et al: Anterior lumbosacral radiculopathy after intrathecal methotrexate treatment. Pediatr Neurol. 21(2):576-8, 1999
Vainionpää L et al: Chemotherapy for acute lymphoblastic leukemia may cause subtle changes of the spinal cord detectable by somatosensory evoked potentials. Med Pediatr Oncol. 28(1):41-7, 1997
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TERMINOLOGY
Definitions
Transient or permanent paraplegia
Uncommon complication following intrathecal chemotherapy
Initially described following intrathecal methotrexate (MTX) in pediatric acute lymphoblastic leukemia patients
Subsequently reported with other chemotherapy agents and in adults
IMAGING
General Features
MR Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Wallis E et al: Avoiding a lumbar puncture may be a rash decision: a case report of varicella-zoster virus-associated radiculopathy in advanced HIV infection. Int J STD AIDS. 30(10):1031-3, 2019
Whalen AM et al: Sacral myeloradiculitis: an uncommon complication of genital herpes infection. Pediatrics. 144(1), 2019
Draak TH et al: Changing outcome in inflammatory neuropathies: Rasch-comparative responsiveness. Neurology. 83(23):2124-32, 2014
Ma YY et al: Guillain-Barré syndrome and severe infection following chemotherapy for peripheral T-cell lymphoma: a case report. Oncol Lett. 8(6):2695-8, 2014
Endo K et al: [An adult Guillain-Barré syndrome patient with enhancement of anterior roots on spinal MRI and severe radicular pain relieved by intravenous methylprednisolone pulse therapy: a case report.] Rinsho Shinkeigaku. 53(7):543-50, 2013
Lee HY et al: Irreversible paraplegia following one time prophylactic intrathecal chemotherapy in an adult patient with acute lymphoblastic leukemia. Yonsei Med J. 49(1):151-4, 2008
Pascual AM et al: Anterior lumbosacral polyradiculopathy after intrathecal administration of methotrexate. J Neurol Sci. 267(1-2):158-61, 2008
Rison RA: Ascending sensory motor polyradiculoneuropathy with cranial nerve involvement following administration of intrathecal methotrexate and intravenous cytarabine in a patient with acute myelogenous leukemia: a case report*. Cases J. 1(1):255, 2008
Santos-García D et al: Pure motor lumbosacral radiculopathy after intrathecal chemotherapy. Eur J Neurol. 15(8):e86-7, 2008
Counsel P et al: Myelopathy due to intrathecal chemotherapy: magnetic resonance imaging findings. Clin Radiol. 62(2):172-6, 2007
Rolf N et al: Acute ascending motoric paraplegia following intrathecal chemotherapy for treatment of acute lymphoblastic leukemia in children: case reports and review of the literature. Klin Padiatr. 218(6):350-4, 2006
Bay A et al: Myelopathy due to intrathecal chemotherapy: report of six cases. J Pediatr Hematol Oncol. 27(5):270-2, 2005
Umeda M et al: [Gadolinium enhancement of the anterior portion of the lumbosacral roots in a case of post-irradiation lumbosacral radiculopathy.] Rinsho Shinkeigaku. 45(10):758-61, 2005
Anderson SC et al: Ventral polyradiculopathy with pediatric acute lymphocytic leukemia. Muscle Nerve. 25(1):106-10, 2002
Koh S et al: Anterior lumbosacral radiculopathy after intrathecal methotrexate treatment. Pediatr Neurol. 21(2):576-8, 1999
Vainionpää L et al: Chemotherapy for acute lymphoblastic leukemia may cause subtle changes of the spinal cord detectable by somatosensory evoked potentials. Med Pediatr Oncol. 28(1):41-7, 1997
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