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Musculoskeletal
Diagnosis
Non-Trauma
Drug-Induced and Nutritional Musculoskeletal Conditions
Drug-Induced Conditions
Antiepileptic Drugs
Antiepileptic Drugs
Nathan D. Cecava, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          Selected References

          1. Min L et al: Effects of valproic acid on skeletal metabolism in children with epilepsy: a systematic evaluation and meta-analysis based on 14 studies. BMC Pediatr. 20(1):97, 2020
          2. Siniscalchi A et al: Antiepileptic drugs and bone health: current concepts. Psychopharmacol Bull. 50(2):36-44, 2020
          3. Fan D et al: Effects of valproic acid on bone mineral density and bone metabolism: a meta-analysis. Seizure. 73:56-63, 2019
          4. Fan HC et al: The impact of anti-epileptic drugs on growth and bone metabolism. Int J Mol Sci. 17(8), 2016
          5. Shen C et al: Association between use of antiepileptic drugs and fracture risk: a systematic review and meta-analysis. Bone. 64:246-53, 2014
          6. Beerhorst K et al: Bone disease during chronic antiepileptic drug therapy: general versus specific risk factors. J Neurol Sci. 331(1-2):19-25, 2013
          7. Sidhu HS et al: Imaging features of therapeutic drug-induced musculoskeletal abnormalities. Radiographics. 32(1):105-27, 2012
          8. Lawson J: Drug-induced metabolic bone disorders. Semin Musculoskelet Radiol. 6(4):285-97, 2002
          Related Anatomy
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          Related Differential Diagnoses
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          References
          Tables

          Tables

          KEY FACTS

          • Terminology

            • Imaging

              • Top Differential Diagnoses

                • Clinical Issues

                  Selected References

                  1. Min L et al: Effects of valproic acid on skeletal metabolism in children with epilepsy: a systematic evaluation and meta-analysis based on 14 studies. BMC Pediatr. 20(1):97, 2020
                  2. Siniscalchi A et al: Antiepileptic drugs and bone health: current concepts. Psychopharmacol Bull. 50(2):36-44, 2020
                  3. Fan D et al: Effects of valproic acid on bone mineral density and bone metabolism: a meta-analysis. Seizure. 73:56-63, 2019
                  4. Fan HC et al: The impact of anti-epileptic drugs on growth and bone metabolism. Int J Mol Sci. 17(8), 2016
                  5. Shen C et al: Association between use of antiepileptic drugs and fracture risk: a systematic review and meta-analysis. Bone. 64:246-53, 2014
                  6. Beerhorst K et al: Bone disease during chronic antiepileptic drug therapy: general versus specific risk factors. J Neurol Sci. 331(1-2):19-25, 2013
                  7. Sidhu HS et al: Imaging features of therapeutic drug-induced musculoskeletal abnormalities. Radiographics. 32(1):105-27, 2012
                  8. Lawson J: Drug-induced metabolic bone disorders. Semin Musculoskelet Radiol. 6(4):285-97, 2002