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Askin Tumor/Ewing Sarcoma of Chest Wall
Arthur B. Meyers, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Pathology

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Synonyms

              • Ewing sarcoma family of tumors (ESFT)
              • Soft tissue primitive neuroectodermal tumor (PNET)
                • Now termed extraskeletal Ewing sarcoma by WHO
            • Definitions

              • Askin tumor: Extraskeletal Ewing sarcoma that occurs in chest wall/thoracopulmonary region
              • Skeletal & extraskeletal Ewing sarcoma & Askin tumor are included in ESFT

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Ultrasonographic Findings

                      • Nuclear Medicine Findings

                        • Imaging Recommendations

                          DIFFERENTIAL DIAGNOSIS

                            PATHOLOGY

                            • General Features

                              • Staging, Grading, & Classification

                                • Gross Pathologic & Surgical Features

                                  • Microscopic Features

                                    CLINICAL ISSUES

                                    • Presentation

                                      • Demographics

                                        • Natural History & Prognosis

                                          • Treatment

                                            DIAGNOSTIC CHECKLIST

                                            • Consider

                                              • Image Interpretation Pearls

                                                Selected References

                                                1. Seitz G et al: Treatment and outcome of patients with thoracic tumors of the Ewing sarcoma family: a report from the Cooperative Weichteilsarkom Studiengruppe CWS-81, -86, -91, -96, and -2002P trials. Pediatr Blood Cancer. 66 Suppl 3:e27884, 2019
                                                2. Provost B et al: Ewing sarcoma of the chest wall: prognostic factors of multimodal therapy including en bloc resection. Ann Thorac Surg. 106(1):207-13, 2018
                                                3. Triarico S et al: Multimodal treatment of pediatric patients with Askin's tumors: our experience. World J Surg Oncol. 16(1):140, 2018
                                                4. Kransdorf M et al: Neurogenic tumors. In Kransdorf M et al: Imaging of Soft Tissue Tumors. 3rd ed. Philadelphia: Lippincott. 449-51, 2014
                                                5. Xia T et al: Askin tumor: CT and FDG-PET/CT imaging findings and follow-up. Medicine (Baltimore). 93(6):e42, 2014
                                                6. Murphey MD et al: From the radiologic pathology archives: Ewing sarcoma family of tumors: radiologic-pathologic correlation. Radiographics. 33(3):803-31, 2013
                                                7. Javery O et al: A to Z of extraskeletal Ewing sarcoma family of tumors in adults: imaging features of primary disease, metastatic patterns, and treatment responses. AJR Am J Roentgenol. 197(6):W1015-22, 2011
                                                8. Winer-Muram HT et al: Primitive neuroectodermal tumors of the chest wall (Askin tumors): CT and MR findings. AJR Am J Roentgenol. 161(2):265-8, 1993
                                                Related Anatomy
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                                                Related Differential Diagnoses
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                                                References
                                                Tables

                                                Tables

                                                KEY FACTS

                                                • Terminology

                                                  • Imaging

                                                    • Pathology

                                                      • Clinical Issues

                                                        • Diagnostic Checklist

                                                          TERMINOLOGY

                                                          • Synonyms

                                                            • Ewing sarcoma family of tumors (ESFT)
                                                            • Soft tissue primitive neuroectodermal tumor (PNET)
                                                              • Now termed extraskeletal Ewing sarcoma by WHO
                                                          • Definitions

                                                            • Askin tumor: Extraskeletal Ewing sarcoma that occurs in chest wall/thoracopulmonary region
                                                            • Skeletal & extraskeletal Ewing sarcoma & Askin tumor are included in ESFT

                                                          IMAGING

                                                          • General Features

                                                            • Radiographic Findings

                                                              • CT Findings

                                                                • MR Findings

                                                                  • Ultrasonographic Findings

                                                                    • Nuclear Medicine Findings

                                                                      • Imaging Recommendations

                                                                        DIFFERENTIAL DIAGNOSIS

                                                                          PATHOLOGY

                                                                          • General Features

                                                                            • Staging, Grading, & Classification

                                                                              • Gross Pathologic & Surgical Features

                                                                                • Microscopic Features

                                                                                  CLINICAL ISSUES

                                                                                  • Presentation

                                                                                    • Demographics

                                                                                      • Natural History & Prognosis

                                                                                        • Treatment

                                                                                          DIAGNOSTIC CHECKLIST

                                                                                          • Consider

                                                                                            • Image Interpretation Pearls

                                                                                              Selected References

                                                                                              1. Seitz G et al: Treatment and outcome of patients with thoracic tumors of the Ewing sarcoma family: a report from the Cooperative Weichteilsarkom Studiengruppe CWS-81, -86, -91, -96, and -2002P trials. Pediatr Blood Cancer. 66 Suppl 3:e27884, 2019
                                                                                              2. Provost B et al: Ewing sarcoma of the chest wall: prognostic factors of multimodal therapy including en bloc resection. Ann Thorac Surg. 106(1):207-13, 2018
                                                                                              3. Triarico S et al: Multimodal treatment of pediatric patients with Askin's tumors: our experience. World J Surg Oncol. 16(1):140, 2018
                                                                                              4. Kransdorf M et al: Neurogenic tumors. In Kransdorf M et al: Imaging of Soft Tissue Tumors. 3rd ed. Philadelphia: Lippincott. 449-51, 2014
                                                                                              5. Xia T et al: Askin tumor: CT and FDG-PET/CT imaging findings and follow-up. Medicine (Baltimore). 93(6):e42, 2014
                                                                                              6. Murphey MD et al: From the radiologic pathology archives: Ewing sarcoma family of tumors: radiologic-pathologic correlation. Radiographics. 33(3):803-31, 2013
                                                                                              7. Javery O et al: A to Z of extraskeletal Ewing sarcoma family of tumors in adults: imaging features of primary disease, metastatic patterns, and treatment responses. AJR Am J Roentgenol. 197(6):W1015-22, 2011
                                                                                              8. Winer-Muram HT et al: Primitive neuroectodermal tumors of the chest wall (Askin tumors): CT and MR findings. AJR Am J Roentgenol. 161(2):265-8, 1993