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Aspergillosis
Terrance Healey, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Synonyms

                • Mycetoma, aspergilloma
                • Most mycetomas are aspergillomas: Terms often used interchangeably
              • Definitions

                • Aspergillosis: Fungal infection caused by organisms of genus Aspergillus (> 100 species)
                • Aspergilloma: Fungus ball developing in preexisting cavity
                • Semi-invasive aspergillosis: Chronic necrotizing pulmonary aspergillosis
                  • Subacute disease in immunosuppressed patient
                • Invasive aspergillosis: Rapidly progressive angioinvasive fungal infection affecting severely immunocompromised patients

              IMAGING

              • General Features

                • Radiographic Findings

                  • CT Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Diagnostic Options

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          • Image Interpretation Pearls

                                            Selected References

                                            1. Kousha M et al: Pulmonary aspergillosis: a clinical review. Eur Respir Rev. 20(121):156-74, 2011
                                            2. Segal BH: Aspergillosis. N Engl J Med. 360(18):1870-84, 2009
                                            3. Rementeria A et al: Genes and molecules involved in Aspergillus fumigatus virulence. Rev Iberoam Micol. 22(1):1-23, 2005
                                            4. Pinto PS: The CT halo sign. Radiology. 230(1):109-10, 2004
                                            5. Kartsonis NA et al: Caspofungin: the first in a new class of antifungal agents. Drug Resist Updat. 6(4):197-218, 2003
                                            6. Abramson S: The air crescent sign. Radiology. 218(1):230-2, 2001
                                            7. Franquet T et al: Spectrum of pulmonary aspergillosis: histologic, clinical, and radiologic findings. Radiographics. 21(4):825-37, 2001
                                            8. Kim SY et al: Semiinvasive pulmonary aspergillosis: CT and pathologic findings in six patients. AJR Am J Roentgenol. 174(3):795-8, 2000
                                            9. Gefter WB: The spectrum of pulmonary aspergillosis. J Thorac Imaging. 7(4):56-74, 1992
                                            10. Libshitz HI et al: Pleural thickening as a manifestation of aspergillus superinfection. Am J Roentgenol Radium Ther Nucl Med. 120(4):883-6, 1974
                                            Related Anatomy
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                                            Related Differential Diagnoses
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                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Terminology

                                              • Imaging

                                                • Top Differential Diagnoses

                                                  • Pathology

                                                    • Clinical Issues

                                                      • Diagnostic Checklist

                                                        TERMINOLOGY

                                                        • Synonyms

                                                          • Mycetoma, aspergilloma
                                                          • Most mycetomas are aspergillomas: Terms often used interchangeably
                                                        • Definitions

                                                          • Aspergillosis: Fungal infection caused by organisms of genus Aspergillus (> 100 species)
                                                          • Aspergilloma: Fungus ball developing in preexisting cavity
                                                          • Semi-invasive aspergillosis: Chronic necrotizing pulmonary aspergillosis
                                                            • Subacute disease in immunosuppressed patient
                                                          • Invasive aspergillosis: Rapidly progressive angioinvasive fungal infection affecting severely immunocompromised patients

                                                        IMAGING

                                                        • General Features

                                                          • Radiographic Findings

                                                            • CT Findings

                                                              • Imaging Recommendations

                                                                DIFFERENTIAL DIAGNOSIS

                                                                  PATHOLOGY

                                                                  • General Features

                                                                    • Gross Pathologic & Surgical Features

                                                                      • Microscopic Features

                                                                        CLINICAL ISSUES

                                                                        • Presentation

                                                                          • Demographics

                                                                            • Diagnostic Options

                                                                              • Natural History & Prognosis

                                                                                • Treatment

                                                                                  DIAGNOSTIC CHECKLIST

                                                                                  • Consider

                                                                                    • Image Interpretation Pearls

                                                                                      Selected References

                                                                                      1. Kousha M et al: Pulmonary aspergillosis: a clinical review. Eur Respir Rev. 20(121):156-74, 2011
                                                                                      2. Segal BH: Aspergillosis. N Engl J Med. 360(18):1870-84, 2009
                                                                                      3. Rementeria A et al: Genes and molecules involved in Aspergillus fumigatus virulence. Rev Iberoam Micol. 22(1):1-23, 2005
                                                                                      4. Pinto PS: The CT halo sign. Radiology. 230(1):109-10, 2004
                                                                                      5. Kartsonis NA et al: Caspofungin: the first in a new class of antifungal agents. Drug Resist Updat. 6(4):197-218, 2003
                                                                                      6. Abramson S: The air crescent sign. Radiology. 218(1):230-2, 2001
                                                                                      7. Franquet T et al: Spectrum of pulmonary aspergillosis: histologic, clinical, and radiologic findings. Radiographics. 21(4):825-37, 2001
                                                                                      8. Kim SY et al: Semiinvasive pulmonary aspergillosis: CT and pathologic findings in six patients. AJR Am J Roentgenol. 174(3):795-8, 2000
                                                                                      9. Gefter WB: The spectrum of pulmonary aspergillosis. J Thorac Imaging. 7(4):56-74, 1992
                                                                                      10. Libshitz HI et al: Pleural thickening as a manifestation of aspergillus superinfection. Am J Roentgenol Radium Ther Nucl Med. 120(4):883-6, 1974