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Astroblastoma
Karen L. Salzman, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            TERMINOLOGY

            • Definitions

              • Rare glial neoplasm with perivascular pseudorosettes and variable biological behavior

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  • Imaging Recommendations

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Staging, Grading, & Classification

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        • Image Interpretation Pearls

                                          Selected References

                                          1. Asha U et al: Lack of IDH1 mutation in astroblastomas suggests putative origin from ependymoglial cells? Neuropathology. ePub, 2015
                                          2. de la Garma VH et al: High-grade astroblastoma in a child: Report of one case and review of literature. Surg Neurol Int. 5:111, 2014
                                          3. Janz C et al: Astroblastoma: report of two cases with unexpected clinical behavior and review of the literature. Clin Neurol Neurosurg. 125:114-24, 2014
                                          4. Ganapathy S et al: Unusual manifestations of astroblastoma: a radiologic-pathologic analysis. Pediatr Radiol. 39(2):168-71, 2009
                                          5. Kantar M et al: Anaplastic astroblastoma of childhood: aggressive behavior. Childs Nerv Syst. 25(9):1125-9, 2009
                                          6. Salvati M et al: Cerebral astroblastoma: analysis of six cases and critical review of treatment options. J Neurooncol. 93(3):369-78, 2009
                                          7. Denaro L et al: Intraventricular astroblastoma. Case report. J Neurosurg Pediatr. 1(2):152-5, 2008
                                          8. Hirano H et al: Consecutive histological changes in an astroblastoma that disseminated to the spinal cord after repeated intracranial recurrences: a case report. Brain Tumor Pathol. 25(1):25-31, 2008
                                          9. Notarianni C et al: Brainstem astroblastoma: a case report and review of the literature. Surg Neurol. 69(2):201-5, 2008
                                          10. Bannykh SI et al: Malignant astroblastoma with rhabdoid morphology. J Neurooncol. 83(3):277-8, 2007
                                          11. Bell JW et al: Neuroradiologic characteristics of astroblastoma. Neuroradiology. 49(3):203-9, 2007
                                          12. Louis DN et al: WHO Classification of Tumours of the Central Nervous System: Astroblastoma. Lyon: IARC Press. 88-9, 2007
                                          13. Mangano FT et al: Astroblastoma. Case report, review of the literature, and analysis of treatment strategies. J Neurosurg Sci. 51(1):21-7; discussion 27, 2007
                                          14. Tumialán LM et al: An astroblastoma mimicking a cavernous malformation: case report. Neurosurgery. 60(3):E569-70; discussion E570, 2007
                                          15. Hata N et al: An astroblastoma case associated with loss of heterozygosity on chromosome 9p. J Neurooncol. 80(1):69-73, 2006
                                          16. Kubota T et al: Astroblastoma: immunohistochemical and ultrastructural study of distinctive epithelial and probable tanycytic differentiation. Neuropathology. 26(1):72-81, 2006
                                          17. Navarro R et al: Astroblastoma in childhood: pathological and clinical analysis. Childs Nerv Syst. 21(3):211-20, 2005
                                          18. Port JD et al: Astroblastoma: radiologic-pathologic correlation and distinction from ependymoma. AJNR Am J Neuroradiol. 23(2):243-7, 2002
                                          19. Sener RN: Astroblastoma: diffusion MRI, and proton MR spectroscopy. Comput Med Imaging Graph. 26(3):187-91, 2002
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Top Differential Diagnoses

                                                • Pathology

                                                  • Clinical Issues

                                                    TERMINOLOGY

                                                    • Definitions

                                                      • Rare glial neoplasm with perivascular pseudorosettes and variable biological behavior

                                                    IMAGING

                                                    • General Features

                                                      • CT Findings

                                                        • MR Findings

                                                          • Imaging Recommendations

                                                            DIFFERENTIAL DIAGNOSIS

                                                              PATHOLOGY

                                                              • General Features

                                                                • Staging, Grading, & Classification

                                                                  • Gross Pathologic & Surgical Features

                                                                    • Microscopic Features

                                                                      CLINICAL ISSUES

                                                                      • Presentation

                                                                        • Demographics

                                                                          • Natural History & Prognosis

                                                                            • Treatment

                                                                              DIAGNOSTIC CHECKLIST

                                                                              • Consider

                                                                                • Image Interpretation Pearls

                                                                                  Selected References

                                                                                  1. Asha U et al: Lack of IDH1 mutation in astroblastomas suggests putative origin from ependymoglial cells? Neuropathology. ePub, 2015
                                                                                  2. de la Garma VH et al: High-grade astroblastoma in a child: Report of one case and review of literature. Surg Neurol Int. 5:111, 2014
                                                                                  3. Janz C et al: Astroblastoma: report of two cases with unexpected clinical behavior and review of the literature. Clin Neurol Neurosurg. 125:114-24, 2014
                                                                                  4. Ganapathy S et al: Unusual manifestations of astroblastoma: a radiologic-pathologic analysis. Pediatr Radiol. 39(2):168-71, 2009
                                                                                  5. Kantar M et al: Anaplastic astroblastoma of childhood: aggressive behavior. Childs Nerv Syst. 25(9):1125-9, 2009
                                                                                  6. Salvati M et al: Cerebral astroblastoma: analysis of six cases and critical review of treatment options. J Neurooncol. 93(3):369-78, 2009
                                                                                  7. Denaro L et al: Intraventricular astroblastoma. Case report. J Neurosurg Pediatr. 1(2):152-5, 2008
                                                                                  8. Hirano H et al: Consecutive histological changes in an astroblastoma that disseminated to the spinal cord after repeated intracranial recurrences: a case report. Brain Tumor Pathol. 25(1):25-31, 2008
                                                                                  9. Notarianni C et al: Brainstem astroblastoma: a case report and review of the literature. Surg Neurol. 69(2):201-5, 2008
                                                                                  10. Bannykh SI et al: Malignant astroblastoma with rhabdoid morphology. J Neurooncol. 83(3):277-8, 2007
                                                                                  11. Bell JW et al: Neuroradiologic characteristics of astroblastoma. Neuroradiology. 49(3):203-9, 2007
                                                                                  12. Louis DN et al: WHO Classification of Tumours of the Central Nervous System: Astroblastoma. Lyon: IARC Press. 88-9, 2007
                                                                                  13. Mangano FT et al: Astroblastoma. Case report, review of the literature, and analysis of treatment strategies. J Neurosurg Sci. 51(1):21-7; discussion 27, 2007
                                                                                  14. Tumialán LM et al: An astroblastoma mimicking a cavernous malformation: case report. Neurosurgery. 60(3):E569-70; discussion E570, 2007
                                                                                  15. Hata N et al: An astroblastoma case associated with loss of heterozygosity on chromosome 9p. J Neurooncol. 80(1):69-73, 2006
                                                                                  16. Kubota T et al: Astroblastoma: immunohistochemical and ultrastructural study of distinctive epithelial and probable tanycytic differentiation. Neuropathology. 26(1):72-81, 2006
                                                                                  17. Navarro R et al: Astroblastoma in childhood: pathological and clinical analysis. Childs Nerv Syst. 21(3):211-20, 2005
                                                                                  18. Port JD et al: Astroblastoma: radiologic-pathologic correlation and distinction from ependymoma. AJNR Am J Neuroradiol. 23(2):243-7, 2002
                                                                                  19. Sener RN: Astroblastoma: diffusion MRI, and proton MR spectroscopy. Comput Med Imaging Graph. 26(3):187-91, 2002