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Atypical Lipomatous Tumor
Catherine C. Roberts, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Pathology

        • Clinical Issues

          TERMINOLOGY

          • Abbreviations

            • Atypical lipomatous tumor (ALT)
            • Well-differentiated liposarcoma (WDL)
          • Synonyms

            • Atypical lipoma, atypical lipomatous neoplasm, adipocytic liposarcoma, lipoma-like liposarcoma, sclerosing liposarcoma, spindle cell liposarcoma, inflammatory liposarcoma
          • Definitions

            • Intermediate, locally aggressive neoplasm composed predominantly of fat
            • WHO designation: ALT/WDL
              • Use of either or both terms is acceptable
              • Some reserve WDL to indicate deep tumors that cannot be completely resected

          IMAGING

          • General Features

            • Imaging Recommendations

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Gross Pathologic & Surgical Features

                          • Microscopic Features

                            CLINICAL ISSUES

                            • Presentation

                              • Demographics

                                • Natural History & Prognosis

                                  • Treatment

                                    Selected References

                                    1. Bestic JM et al: Sclerosing variant of well-differentiated liposarcoma: relative prevalence and spectrum of CT and MRI features. AJR Am J Roentgenol. 201(1):154-61, 2013
                                    2. Brisson M et al: MRI characteristics of lipoma and atypical lipomatous tumor/well-differentiated liposarcoma: retrospective comparison with histology and MDM2 gene amplification. Skeletal Radiol. 42(5):635-47, 2013
                                    3. Bidault F et al: Liposarcoma or lipoma: does genetics change classic imaging criteria? Eur J Radiol. 72(1):22-6, 2009
                                    4. Weiss SW et al: Liposarcoma. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Philadelphia: Elsevier. 482-93, 2008
                                    5. Kransdorf MJ et al: Lipomatous tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 2nd ed. Philadelphia: Lippincott Williams & Wilkins. 125-38, 2006
                                    6. Dei Tos AP et al: Atypical lipomatous tumour/well differentiated liposarcoma. In Fletcher CDM et al: World Health Organisation Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. Lyon: IARC Press. 35-7, 2002
                                    Related Anatomy
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                                    Related Differential Diagnoses
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                                    References
                                    Tables

                                    Tables

                                    KEY FACTS

                                    • Terminology

                                      • Imaging

                                        • Pathology

                                          • Clinical Issues

                                            TERMINOLOGY

                                            • Abbreviations

                                              • Atypical lipomatous tumor (ALT)
                                              • Well-differentiated liposarcoma (WDL)
                                            • Synonyms

                                              • Atypical lipoma, atypical lipomatous neoplasm, adipocytic liposarcoma, lipoma-like liposarcoma, sclerosing liposarcoma, spindle cell liposarcoma, inflammatory liposarcoma
                                            • Definitions

                                              • Intermediate, locally aggressive neoplasm composed predominantly of fat
                                              • WHO designation: ALT/WDL
                                                • Use of either or both terms is acceptable
                                                • Some reserve WDL to indicate deep tumors that cannot be completely resected

                                            IMAGING

                                            • General Features

                                              • Imaging Recommendations

                                                • Radiographic Findings

                                                  • CT Findings

                                                    • MR Findings

                                                      DIFFERENTIAL DIAGNOSIS

                                                        PATHOLOGY

                                                        • General Features

                                                          • Gross Pathologic & Surgical Features

                                                            • Microscopic Features

                                                              CLINICAL ISSUES

                                                              • Presentation

                                                                • Demographics

                                                                  • Natural History & Prognosis

                                                                    • Treatment

                                                                      Selected References

                                                                      1. Bestic JM et al: Sclerosing variant of well-differentiated liposarcoma: relative prevalence and spectrum of CT and MRI features. AJR Am J Roentgenol. 201(1):154-61, 2013
                                                                      2. Brisson M et al: MRI characteristics of lipoma and atypical lipomatous tumor/well-differentiated liposarcoma: retrospective comparison with histology and MDM2 gene amplification. Skeletal Radiol. 42(5):635-47, 2013
                                                                      3. Bidault F et al: Liposarcoma or lipoma: does genetics change classic imaging criteria? Eur J Radiol. 72(1):22-6, 2009
                                                                      4. Weiss SW et al: Liposarcoma. In Weiss SW et al: Enzinger and Weiss' Soft Tissue Tumors. 5th ed. Philadelphia: Elsevier. 482-93, 2008
                                                                      5. Kransdorf MJ et al: Lipomatous tumors. In Kransdorf MJ et al: Imaging of Soft Tissue Tumors. 2nd ed. Philadelphia: Lippincott Williams & Wilkins. 125-38, 2006
                                                                      6. Dei Tos AP et al: Atypical lipomatous tumour/well differentiated liposarcoma. In Fletcher CDM et al: World Health Organisation Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. Lyon: IARC Press. 35-7, 2002