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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Synonyms
Papilloma with atypia; atypical papillary lesion
Definitions
Papilloma or papillary lesion with
Associated atypical ductal hyperplasia (ADH) within or adjacent
Or associated monomorphic proliferation which would otherwise meet criteria for low-grade DCIS but < 3 mm in size
Cellular atypia in a papilloma can be seen but no longer = atypical papilloma
IMAGING
General Features
Mammographic Findings
Ultrasonographic Findings
MR Findings
Image-Guided Biopsy
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
Microscopic Features
CLINICAL ISSUES
Presentation
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
Falomo E et al: Variability in the management recommendations given for high-risk breast lesions detected on image-guided core needle biopsy at U.S. academic institutions. Curr Probl Diagn Radiol. ePub, 2018
Khan S et al: Papillary lesions of the breast: To excise or observe? Breast J. 24(3):350-355, 2018
Kiran S et al: Are we overtreating intraductal papillomas? J Surg Res. 231:387-394, 2018
Lamb LR et al: Pathologic upgrade rates of high-risk breast lesions on digital two-dimensional vs tomosynthesis mammography. J Am Coll Surg. 226(5):858-867, 2018
Symbol B et al: Management of intraductal papilloma without atypia of the breast diagnosed on core biopsy: Size and sampling matter. Breast J. 24(5):738-742, 2018
Ahn SK et al: Management of benign papilloma without atypia diagnosed at ultrasound-guided core needle biopsy: Scoring system for predicting malignancy. Eur J Surg Oncol. ePub, 2017
Rageth CJ et al: First International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions). Breast Cancer Res Treat. 159(2):203-13, 2016
Yang Y et al: The significance of combined CK5/6 and p63 immunohistochemistry in predicting the risks of subsequent carcinoma development in intraductal papilloma of the breast. Pathol Int. 65(2):81-8, 2015
Wen X et al: Nonmalignant breast papillary lesions at core-needle biopsy: a meta-analysis of underestimation and influencing factors. Ann Surg Oncol. 20(1):94-101, 2013
Brennan SB et al: Papilloma diagnosed at MRI-guided vacuum-assisted breast biopsy: is surgical excision still warranted? AJR Am J Roentgenol. 199(4):W512-9, 2012
Fu CY et al: Papillary breast lesions diagnosed by core biopsy require complete excision. Eur J Surg Oncol. 38(11):1029-35, 2012
Zhu Y et al: Solitary intraductal papillomas of the breast: MRI features and differentiation from small invasive ductal carcinomas. AJR Am J Roentgenol. 199(4):936-42, 2012
Chang JM et al: Papillary lesions initially diagnosed at ultrasound-guided vacuum-assisted breast biopsy: rate of malignancy based on subsequent surgical excision. Ann Surg Oncol. 18(9):2506-14, 2011
Kim MJ et al: The diagnosis of non-malignant papillary lesions of the breast: comparison of ultrasound-guided automated gun biopsy and vacuum-assisted removal. Clin Radiol. 66(6):530-5, 2011
Jung SY et al: Risk factors for malignancy in benign papillomas of the breast on core needle biopsy. World J Surg. 34(2):261-5, 2010
Youk JH et al: Atypical papilloma diagnosed by sonographically guided 14-gauge core needle biopsy of breast mass. AJR Am J Roentgenol. 194(5):1397-402, 2010
Bode MK et al: Ultrasonography-guided core needle biopsy in differential diagnosis of papillary breast tumors. Acta Radiol. 50(7):722-9, 2009
Cheng TY et al: Risk factors associated with conversion from nonmalignant to malignant diagnosis after surgical excision of breast papillary lesions. Ann Surg Oncol. 16(12):3375-9, 2009
Tseng HS et al: The management of papillary lesion of the breast by core needle biopsy. Eur J Surg Oncol. 35(1):21-4, 2009
Ueng SH et al: Papillary neoplasms of the breast: a review. Arch Pathol Lab Med. 133(6):893-907, 2009
Kil WH et al: Is surgical excision necessary in benign papillary lesions initially diagnosed at core biopsy? Breast. 17(3):258-62, 2008
Shin HJ et al: Papillary lesions of the breast diagnosed at percutaneous sonographically guided biopsy: comparison of sonographic features and biopsy methods. AJR Am J Roentgenol. 190(3):630-6, 2008
Ko ES et al: Sonographically-guided 14-gauge core needle biopsy for papillary lesions of the breast. Korean J Radiol. 8(3):206-11, 2007
Lewis JT et al: An analysis of breast cancer risk in women with single, multiple, and atypical papilloma. Am J Surg Pathol. 30:665-72, 2006
Liberman L et al: Is surgical excision warranted after benign, concordant diagnosis of papilloma at percutaneous breast biopsy? AJR Am J Roentgenol. 186(5):1328-34, 2006
Mercado CL et al: Papillary lesions of the breast at percutaneous core-needle biopsy. Radiology. 238(3):801-8, 2006
Mercado CL et al: Papillary lesions of the breast: evaluation with stereotactic directional vacuum-assisted biopsy. Radiology. 221(3):650-5, 2001
Orel SG et al: MR imaging in patients with nipple discharge: initial experience. Radiology. 216(1):248-54, 2000
Hild F et al: Ductal orientated sonography improves the diagnosis of pathological nipple discharge of the female breast compared with galactography. Eur J Cancer Prev. 7 Suppl 1:S57-62, 1998
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Synonyms
Papilloma with atypia; atypical papillary lesion
Definitions
Papilloma or papillary lesion with
Associated atypical ductal hyperplasia (ADH) within or adjacent
Or associated monomorphic proliferation which would otherwise meet criteria for low-grade DCIS but < 3 mm in size
Cellular atypia in a papilloma can be seen but no longer = atypical papilloma
IMAGING
General Features
Mammographic Findings
Ultrasonographic Findings
MR Findings
Image-Guided Biopsy
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
Microscopic Features
CLINICAL ISSUES
Presentation
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
Falomo E et al: Variability in the management recommendations given for high-risk breast lesions detected on image-guided core needle biopsy at U.S. academic institutions. Curr Probl Diagn Radiol. ePub, 2018
Khan S et al: Papillary lesions of the breast: To excise or observe? Breast J. 24(3):350-355, 2018
Kiran S et al: Are we overtreating intraductal papillomas? J Surg Res. 231:387-394, 2018
Lamb LR et al: Pathologic upgrade rates of high-risk breast lesions on digital two-dimensional vs tomosynthesis mammography. J Am Coll Surg. 226(5):858-867, 2018
Symbol B et al: Management of intraductal papilloma without atypia of the breast diagnosed on core biopsy: Size and sampling matter. Breast J. 24(5):738-742, 2018
Ahn SK et al: Management of benign papilloma without atypia diagnosed at ultrasound-guided core needle biopsy: Scoring system for predicting malignancy. Eur J Surg Oncol. ePub, 2017
Rageth CJ et al: First International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions). Breast Cancer Res Treat. 159(2):203-13, 2016
Yang Y et al: The significance of combined CK5/6 and p63 immunohistochemistry in predicting the risks of subsequent carcinoma development in intraductal papilloma of the breast. Pathol Int. 65(2):81-8, 2015
Wen X et al: Nonmalignant breast papillary lesions at core-needle biopsy: a meta-analysis of underestimation and influencing factors. Ann Surg Oncol. 20(1):94-101, 2013
Brennan SB et al: Papilloma diagnosed at MRI-guided vacuum-assisted breast biopsy: is surgical excision still warranted? AJR Am J Roentgenol. 199(4):W512-9, 2012
Fu CY et al: Papillary breast lesions diagnosed by core biopsy require complete excision. Eur J Surg Oncol. 38(11):1029-35, 2012
Zhu Y et al: Solitary intraductal papillomas of the breast: MRI features and differentiation from small invasive ductal carcinomas. AJR Am J Roentgenol. 199(4):936-42, 2012
Chang JM et al: Papillary lesions initially diagnosed at ultrasound-guided vacuum-assisted breast biopsy: rate of malignancy based on subsequent surgical excision. Ann Surg Oncol. 18(9):2506-14, 2011
Kim MJ et al: The diagnosis of non-malignant papillary lesions of the breast: comparison of ultrasound-guided automated gun biopsy and vacuum-assisted removal. Clin Radiol. 66(6):530-5, 2011
Jung SY et al: Risk factors for malignancy in benign papillomas of the breast on core needle biopsy. World J Surg. 34(2):261-5, 2010
Youk JH et al: Atypical papilloma diagnosed by sonographically guided 14-gauge core needle biopsy of breast mass. AJR Am J Roentgenol. 194(5):1397-402, 2010
Bode MK et al: Ultrasonography-guided core needle biopsy in differential diagnosis of papillary breast tumors. Acta Radiol. 50(7):722-9, 2009
Cheng TY et al: Risk factors associated with conversion from nonmalignant to malignant diagnosis after surgical excision of breast papillary lesions. Ann Surg Oncol. 16(12):3375-9, 2009
Tseng HS et al: The management of papillary lesion of the breast by core needle biopsy. Eur J Surg Oncol. 35(1):21-4, 2009
Ueng SH et al: Papillary neoplasms of the breast: a review. Arch Pathol Lab Med. 133(6):893-907, 2009
Kil WH et al: Is surgical excision necessary in benign papillary lesions initially diagnosed at core biopsy? Breast. 17(3):258-62, 2008
Shin HJ et al: Papillary lesions of the breast diagnosed at percutaneous sonographically guided biopsy: comparison of sonographic features and biopsy methods. AJR Am J Roentgenol. 190(3):630-6, 2008
Ko ES et al: Sonographically-guided 14-gauge core needle biopsy for papillary lesions of the breast. Korean J Radiol. 8(3):206-11, 2007
Lewis JT et al: An analysis of breast cancer risk in women with single, multiple, and atypical papilloma. Am J Surg Pathol. 30:665-72, 2006
Liberman L et al: Is surgical excision warranted after benign, concordant diagnosis of papilloma at percutaneous breast biopsy? AJR Am J Roentgenol. 186(5):1328-34, 2006
Mercado CL et al: Papillary lesions of the breast at percutaneous core-needle biopsy. Radiology. 238(3):801-8, 2006
Mercado CL et al: Papillary lesions of the breast: evaluation with stereotactic directional vacuum-assisted biopsy. Radiology. 221(3):650-5, 2001
Orel SG et al: MR imaging in patients with nipple discharge: initial experience. Radiology. 216(1):248-54, 2000
Hild F et al: Ductal orientated sonography improves the diagnosis of pathological nipple discharge of the female breast compared with galactography. Eur J Cancer Prev. 7 Suppl 1:S57-62, 1998
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