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Autoimmune Hepatitis
Atif Zaheer, MD; Michael P. Federle, MD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Abbreviations

              • Autoimmune hepatitis (AIH)
            • Synonyms

              • Chronic active hepatitis
            • Definitions

              • Uncommon, chronic hepatitis of unknown etiology characterized by hyperglobulinemia, circulating autoantibodies, and inflammatory changes on hepatic histology

            IMAGING

            • General Features

              • Radiographic Findings

                • CT Findings

                  • MR Findings

                    • Ultrasonographic Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • Staging, Grading, & Classification

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          Selected References

                                          1. Gomes NBN et al: Autoimmune hepatitis in practice, from diagnosis to complications: what is the role of imaging? A clinicoradiological review. Clin Imaging. 74:31-40, 2021
                                          2. Mieli-Vergani G et al: Autoimmune hepatitis. Nat Rev Dis Primers. 4:18017, 2018
                                          3. Malik N et al: Imaging of autoimmune hepatitis and overlap syndromes. Abdom Radiol (NY). 42(1):19-27, 2017
                                          4. Weidner J et al: Marked improvement of the autoimmune syndrome associated with autoimmune hepatitis by treatment with sympathomimetic amines. Clin Exp Obstet Gynecol. 41(4):460-1, 2014
                                          5. Culver EL et al: Systematic review: management options for primary sclerosing cholangitis and its variant forms - IgG4-associated cholangitis and overlap with autoimmune hepatitis. Aliment Pharmacol Ther. 33(12):1273-91, 2011
                                          6. Czaja AJ: Cryptogenic chronic hepatitis and its changing guise in adults. Dig Dis Sci. 56(12):3421-38, 2011
                                          7. Jothimani D et al: Treatment of autoimmune hepatitis: a review of current and evolving therapies. J Gastroenterol Hepatol. 26(4):619-27, 2011
                                          8. Lohse AW et al: Autoimmune hepatitis. J Hepatol. 55(1):171-82, 2011
                                          9. Mayo MJ: Management of autoimmune hepatitis. Curr Opin Gastroenterol. 27(3):224-30, 2011
                                          10. Mieli-Vergani G et al: Autoimmune hepatitis. Nat Rev Gastroenterol Hepatol. 8(6):320-9, 2011
                                          11. Potts JR et al: Optimizing management in autoimmune hepatitis with liver failure at initial presentation. World J Gastroenterol. 17(16):2070-5, 2011
                                          12. Vergani D et al: Pharmacological management of autoimmune hepatitis. Expert Opin Pharmacother. 12(4):607-13, 2011
                                          13. Sahni VA et al: Autoimmune hepatitis: CT and MR imaging features with histopathological correlation. Abdom Imaging. 35(1):75-84, 2010
                                          14. Strassburg CP: Autoimmune hepatitis. Best Pract Res Clin Gastroenterol. 24(5):667-82, 2010
                                          15. Bilaj F et al: MR imaging findings in autoimmune hepatitis: correlation with clinical staging. Radiology. 236(3):896-902, 2005
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Top Differential Diagnoses

                                                • Clinical Issues

                                                  • Diagnostic Checklist

                                                    TERMINOLOGY

                                                    • Abbreviations

                                                      • Autoimmune hepatitis (AIH)
                                                    • Synonyms

                                                      • Chronic active hepatitis
                                                    • Definitions

                                                      • Uncommon, chronic hepatitis of unknown etiology characterized by hyperglobulinemia, circulating autoantibodies, and inflammatory changes on hepatic histology

                                                    IMAGING

                                                    • General Features

                                                      • Radiographic Findings

                                                        • CT Findings

                                                          • MR Findings

                                                            • Ultrasonographic Findings

                                                              • Imaging Recommendations

                                                                DIFFERENTIAL DIAGNOSIS

                                                                  PATHOLOGY

                                                                  • Staging, Grading, & Classification

                                                                    • Gross Pathologic & Surgical Features

                                                                      • Microscopic Features

                                                                        CLINICAL ISSUES

                                                                        • Presentation

                                                                          • Demographics

                                                                            • Natural History & Prognosis

                                                                              • Treatment

                                                                                DIAGNOSTIC CHECKLIST

                                                                                • Consider

                                                                                  Selected References

                                                                                  1. Gomes NBN et al: Autoimmune hepatitis in practice, from diagnosis to complications: what is the role of imaging? A clinicoradiological review. Clin Imaging. 74:31-40, 2021
                                                                                  2. Mieli-Vergani G et al: Autoimmune hepatitis. Nat Rev Dis Primers. 4:18017, 2018
                                                                                  3. Malik N et al: Imaging of autoimmune hepatitis and overlap syndromes. Abdom Radiol (NY). 42(1):19-27, 2017
                                                                                  4. Weidner J et al: Marked improvement of the autoimmune syndrome associated with autoimmune hepatitis by treatment with sympathomimetic amines. Clin Exp Obstet Gynecol. 41(4):460-1, 2014
                                                                                  5. Culver EL et al: Systematic review: management options for primary sclerosing cholangitis and its variant forms - IgG4-associated cholangitis and overlap with autoimmune hepatitis. Aliment Pharmacol Ther. 33(12):1273-91, 2011
                                                                                  6. Czaja AJ: Cryptogenic chronic hepatitis and its changing guise in adults. Dig Dis Sci. 56(12):3421-38, 2011
                                                                                  7. Jothimani D et al: Treatment of autoimmune hepatitis: a review of current and evolving therapies. J Gastroenterol Hepatol. 26(4):619-27, 2011
                                                                                  8. Lohse AW et al: Autoimmune hepatitis. J Hepatol. 55(1):171-82, 2011
                                                                                  9. Mayo MJ: Management of autoimmune hepatitis. Curr Opin Gastroenterol. 27(3):224-30, 2011
                                                                                  10. Mieli-Vergani G et al: Autoimmune hepatitis. Nat Rev Gastroenterol Hepatol. 8(6):320-9, 2011
                                                                                  11. Potts JR et al: Optimizing management in autoimmune hepatitis with liver failure at initial presentation. World J Gastroenterol. 17(16):2070-5, 2011
                                                                                  12. Vergani D et al: Pharmacological management of autoimmune hepatitis. Expert Opin Pharmacother. 12(4):607-13, 2011
                                                                                  13. Sahni VA et al: Autoimmune hepatitis: CT and MR imaging features with histopathological correlation. Abdom Imaging. 35(1):75-84, 2010
                                                                                  14. Strassburg CP: Autoimmune hepatitis. Best Pract Res Clin Gastroenterol. 24(5):667-82, 2010
                                                                                  15. Bilaj F et al: MR imaging findings in autoimmune hepatitis: correlation with clinical staging. Radiology. 236(3):896-902, 2005