Inherited polycystic renal disease characterized by progressive cystic growth, renal failure, and multiple systemic manifestations
IMAGING
General Features
Ultrasonographic Findings
CT Findings
MR Findings
Other Renal Findings
Extrarenal Manifestations
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Reporting Tips
Selected References
Gaur P et al: ADPKD-what the radiologist should know. Br J Radiol. 92(1098):20190078, 2019
Murray N et al: Dual-energy CT in evaluation of the acute abdomen. Radiographics. 39(1):264-86, 2019
Jeudy J et al: Spectrum of coronary artery aneurysms: from the radiologic pathology archives. Radiographics. 38(1):11-36, 2018
Dillman JR et al: Hereditary renal cystic disorders: imaging of the kidneys and beyond. Radiographics. 37(3):924-46, 2017
Kim B et al: Inherited renal cystic diseases. Abdom Radiol (NY). 41(6):1035-51, 2016
Kim JA et al: Pancreatic cysts in autosomal dominant polycystic kidney disease: prevalence and association with PKD2 gene mutations. Radiology. 280(3):762-70, 2016
Harvey CJ et al: Role of US contrast agents in the assessment of indeterminate solid and cystic lesions in native and transplant kidneys. Radiographics. 35(5):1419-30, 2015
Hogan MC et al: Liver involvement in early autosomal-dominant polycystic kidney disease. Clin Gastroenterol Hepatol. 13(1):155-64.e6, 2015
Reig B et al: Seminal megavesicle in autosomal dominant polycystic kidney disease. Clin Imaging. 39(2):289-92, 2015
Tellman MW et al: Management of pain in autosomal dominant polycystic kidney disease and anatomy of renal innervation. J Urol. 193(5):1470-8, 2015
Wood CG 3rd et al: CT and MR imaging for evaluation of cystic renal lesions and diseases. Radiographics. 35(1):125-41, 2015
Chung EM et al: From the radiologic pathology archives: pediatric polycystic kidney disease and other ciliopathies: radiologic-pathologic correlation. Radiographics. 34(1):155-78, 2014
Kanaan N et al: Renal transplantation in autosomal dominant polycystic kidney disease. Nat Rev Nephrol. 10(8):455-65, 2014
Patel MS et al: Trends in the management and outcomes of kidney transplantation for autosomal dominant polycystic kidney disease. J Transplant. 2014:675697, 2014
Rahbari-Oskoui F et al: Renal relevant radiology: radiologic imaging in autosomal dominant polycystic kidney disease. Clin J Am Soc Nephrol. 9(2):406-15, 2014
Chapman AB et al: Kidney volume and functional outcomes in autosomal dominant polycystic kidney disease. Clin J Am Soc Nephrol. 7(3):479-86, 2012
Grantham JJ et al: Detected renal cysts are tips of the iceberg in adults with ADPKD. Clin J Am Soc Nephrol. 7(7):1087-93, 2012
Grantham JJ et al: Why kidneys fail in autosomal dominant polycystic kidney disease. Nat Rev Nephrol. 7(10):556-66, 2011
Bae KT et al: Imaging for the prognosis of autosomal dominant polycystic kidney disease. Nat Rev Nephrol. 6(2):96-106, 2010
Katabathina VS et al: Adult renal cystic disease: a genetic, biological, and developmental primer. Radiographics. 30(6):1509-23, 2010
Gonçalves S et al: Autosomal-dominant polycystic kidney disease and kidney transplantation: experience of a single center. Transplant Proc. 41(3):887-90, 2009
Harris PC et al: Polycystic kidney disease. Annu Rev Med. 60:321-37, 2009
Pei Y et al: Unified criteria for ultrasonographic diagnosis of ADPKD. J Am Soc Nephrol. 20(1):205-12, 2009
Zhao X et al: Molecular diagnostics in autosomal dominant polycystic kidney disease: utility and limitations. Clin J Am Soc Nephrol. 3(1):146-52, 2008
Grantham JJ et al: Volume progression in polycystic kidney disease. N Engl J Med. 354(20):2122-30, 2006
Harris PC et al: Cyst number but not the rate of cystic growth is associated with the mutated gene in autosomal dominant polycystic kidney disease. J Am Soc Nephrol. 17(11):3013-9, 2006
Morgan DE et al: Polycystic liver disease: multimodality imaging for complications and transplant evaluation. Radiographics. 26(6):1655-68; quiz 1655, 2006
Truong LD et al: Renal cystic neoplasms and renal neoplasms associated with cystic renal diseases: pathogenetic and molecular links. Adv Anat Pathol. 10(3):135-59, 2003
Nascimento AB et al: Rapid MR imaging detection of renal cysts: age-based standards. Radiology 221: 628-32, 2001
Perrone RD et al: Survival after end-stage renal disease in autosomal dominant polycystic kidney disease: contribution of extrarenal complications to mortality. Am J Kidney Dis. 38(4):777-84, 2001
Hateboer N et al: Comparison of phenotypes of polycystic kidney disease types 1 and 2. European PKD1-PKD2 Study Group. Lancet. 353(9147):103-7, 1999
Nicolau C et al: Autosomal dominant polycystic kidney disease types 1 and 2: Assessment of US sensitivity for diagnosis. Radiology 213: 273-6, 1999
Franz KA et al: Rate of functional deterioration in polycystic kidney disease. Kidney Int. 23(3):526-9, 1983
Inherited polycystic renal disease characterized by progressive cystic growth, renal failure, and multiple systemic manifestations
IMAGING
General Features
Ultrasonographic Findings
CT Findings
MR Findings
Other Renal Findings
Extrarenal Manifestations
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Reporting Tips
Selected References
Gaur P et al: ADPKD-what the radiologist should know. Br J Radiol. 92(1098):20190078, 2019
Murray N et al: Dual-energy CT in evaluation of the acute abdomen. Radiographics. 39(1):264-86, 2019
Jeudy J et al: Spectrum of coronary artery aneurysms: from the radiologic pathology archives. Radiographics. 38(1):11-36, 2018
Dillman JR et al: Hereditary renal cystic disorders: imaging of the kidneys and beyond. Radiographics. 37(3):924-46, 2017
Kim B et al: Inherited renal cystic diseases. Abdom Radiol (NY). 41(6):1035-51, 2016
Kim JA et al: Pancreatic cysts in autosomal dominant polycystic kidney disease: prevalence and association with PKD2 gene mutations. Radiology. 280(3):762-70, 2016
Harvey CJ et al: Role of US contrast agents in the assessment of indeterminate solid and cystic lesions in native and transplant kidneys. Radiographics. 35(5):1419-30, 2015
Hogan MC et al: Liver involvement in early autosomal-dominant polycystic kidney disease. Clin Gastroenterol Hepatol. 13(1):155-64.e6, 2015
Reig B et al: Seminal megavesicle in autosomal dominant polycystic kidney disease. Clin Imaging. 39(2):289-92, 2015
Tellman MW et al: Management of pain in autosomal dominant polycystic kidney disease and anatomy of renal innervation. J Urol. 193(5):1470-8, 2015
Wood CG 3rd et al: CT and MR imaging for evaluation of cystic renal lesions and diseases. Radiographics. 35(1):125-41, 2015
Chung EM et al: From the radiologic pathology archives: pediatric polycystic kidney disease and other ciliopathies: radiologic-pathologic correlation. Radiographics. 34(1):155-78, 2014
Kanaan N et al: Renal transplantation in autosomal dominant polycystic kidney disease. Nat Rev Nephrol. 10(8):455-65, 2014
Patel MS et al: Trends in the management and outcomes of kidney transplantation for autosomal dominant polycystic kidney disease. J Transplant. 2014:675697, 2014
Rahbari-Oskoui F et al: Renal relevant radiology: radiologic imaging in autosomal dominant polycystic kidney disease. Clin J Am Soc Nephrol. 9(2):406-15, 2014
Chapman AB et al: Kidney volume and functional outcomes in autosomal dominant polycystic kidney disease. Clin J Am Soc Nephrol. 7(3):479-86, 2012
Grantham JJ et al: Detected renal cysts are tips of the iceberg in adults with ADPKD. Clin J Am Soc Nephrol. 7(7):1087-93, 2012
Grantham JJ et al: Why kidneys fail in autosomal dominant polycystic kidney disease. Nat Rev Nephrol. 7(10):556-66, 2011
Bae KT et al: Imaging for the prognosis of autosomal dominant polycystic kidney disease. Nat Rev Nephrol. 6(2):96-106, 2010
Katabathina VS et al: Adult renal cystic disease: a genetic, biological, and developmental primer. Radiographics. 30(6):1509-23, 2010
Gonçalves S et al: Autosomal-dominant polycystic kidney disease and kidney transplantation: experience of a single center. Transplant Proc. 41(3):887-90, 2009
Harris PC et al: Polycystic kidney disease. Annu Rev Med. 60:321-37, 2009
Pei Y et al: Unified criteria for ultrasonographic diagnosis of ADPKD. J Am Soc Nephrol. 20(1):205-12, 2009
Zhao X et al: Molecular diagnostics in autosomal dominant polycystic kidney disease: utility and limitations. Clin J Am Soc Nephrol. 3(1):146-52, 2008
Grantham JJ et al: Volume progression in polycystic kidney disease. N Engl J Med. 354(20):2122-30, 2006
Harris PC et al: Cyst number but not the rate of cystic growth is associated with the mutated gene in autosomal dominant polycystic kidney disease. J Am Soc Nephrol. 17(11):3013-9, 2006
Morgan DE et al: Polycystic liver disease: multimodality imaging for complications and transplant evaluation. Radiographics. 26(6):1655-68; quiz 1655, 2006
Truong LD et al: Renal cystic neoplasms and renal neoplasms associated with cystic renal diseases: pathogenetic and molecular links. Adv Anat Pathol. 10(3):135-59, 2003
Nascimento AB et al: Rapid MR imaging detection of renal cysts: age-based standards. Radiology 221: 628-32, 2001
Perrone RD et al: Survival after end-stage renal disease in autosomal dominant polycystic kidney disease: contribution of extrarenal complications to mortality. Am J Kidney Dis. 38(4):777-84, 2001
Hateboer N et al: Comparison of phenotypes of polycystic kidney disease types 1 and 2. European PKD1-PKD2 Study Group. Lancet. 353(9147):103-7, 1999
Nicolau C et al: Autosomal dominant polycystic kidney disease types 1 and 2: Assessment of US sensitivity for diagnosis. Radiology 213: 273-6, 1999
Franz KA et al: Rate of functional deterioration in polycystic kidney disease. Kidney Int. 23(3):526-9, 1983
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