Chronic, idiopathic, relapsing-remitting, multisystem vascular-inflammatory disease characterized by recurrent orogenital ulcerations and uveitis
CNS involved in up to 20-25% of patients
IMAGING
General Features
Imaging Recommendations
CT Findings
MR Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
Alghamdi A et al: Neuro-ophthalmological manifestations of Behçet's disease. Br J Ophthalmol. 103(1):83-7, 2019
Borhani-Haghighi A et al: Neuro-Behcet's disease: an update on diagnosis, differential diagnoses, and treatment. Mult Scler Relat Disord. 39:101906, 2019
Guedes-Barbosa LS: Oral and genital ulcers in Behçet's disease. N Engl J Med. 380(6):e7, 2019
Law LY et al: The spectrum of immune-mediated and inflammatory lesions of the brainstem: clues to diagnosis. Neurology. 93(9):390-405, 2019
Uygunoğlu U et al: Nervous system involvement in Behçet's syndrome. Curr Opin Rheumatol. 31(1):32-9, 2019
Yan D et al: The clinical features and risk factors of parenchymal neuro-Behcet's disease. J Immunol Res. 2019:7371458, 2019
Uygunoğlu U et al: Behçet's syndrome and nervous system involvement. Curr Neurol Neurosci Rep. 18(7):35, 2018
Uygunoglu U et al: Myelopathy in Behçet's disease: the bagel sign. Ann Neurol. 82(2):288-98, 2017
Alonso S et al: Pseudotumoral Behçet's disease. Reumatol Clin. 12(2):85-90, 2016
Miller JJ et al: Neuro-behçet disease and autoinflammatory disorders. Semin Neurol. 34(4):437-43, 2014
Noel N et al: Long-term outcome of neuro-Behçet's disease. Arthritis Rheumatol. 66(5):1306-14, 2014
Saip S et al: Neuro-Behçet syndrome. Handb Clin Neurol. 121:1703-23, 2014
Mora P et al: Neuro-Behçet's disease in childhood: a focus on the neuro-ophthalmological features. Orphanet J Rare Dis. 8:18, 2013
Farahangiz S et al: Magnetic resonance imaging findings and outcome of neuro-Behçet's disease: the predictive factors. Int J Rheum Dis. 15(6):e142-9, 2012
Peño IC et al: Neurobehçet disease: clinical and demographic characteristics. Eur J Neurol. 19(9):1224-7, 2012
Uluduz D et al: Clinical characteristics of pediatric-onset neuro-Behçet disease. Neurology. 77(21):1900-5, 2011
Kale N et al: The presentation of headache in neuro-Behçet's disease: a case-series. Headache. 49(3):467-70, 2009
Siva A et al: The spectrum of nervous system involvement in Behçet's syndrome and its differential diagnosis. J Neurol. 256(4):513-29, 2009
Taskapilioglu O et al: Delayed diagnosis of a neuroBehçet patient with only brainstem and cerebellar atrophy: literature review. J Neurol Sci. 277(1-2):160-3, 2009
Deprez FC et al: MRI features of Neuro-Behçet disease. JBR-BTR. 91(5):221, 2008
Heo JH et al: Neuro-Behcet's disease mimicking multiple brain tumors: diffusion-weighted MR study and literature review. J Neurol Sci. 264(1-2):177-81, 2008
Moratalla MB: Central nervous system involvement in Behçet's syndrome. J Rheumatol. 35(1):175-6, 2008
Haghighi AB et al: The pathological presentations of neuro-Behçet disease: a case report and review of the literature. Neurologist. 13(4):209-14, 2007
Joseph FG et al: Neuro-Behçet's disease in Caucasians: a study of 22 patients. Eur J Neurol. 14(2):174-80, 2007
Appenzeller S et al: Brain tumor-like lesion in Behçet disease. Rheumatol Int. 26(6):577-80, 2006
Baysal T et al: Diffusion-weighted imaging in chronic Behçet patients with and without neurological findings. Neuroradiology. 47(6):431-7, 2005
Hasegawa T et al: Neuro-Behçet's disease presenting initially as mesiotemporal lesions mimicking herpes simplex encephalitis. Eur J Neurol. 12(8):661-2, 2005
Matsuo K et al: Neuro-Behçet disease mimicking brain tumor. AJNR Am J Neuroradiol. 26(3):650-3, 2005
Cengiz N et al: Correlation of clinical, MRI and Tc-99m HMPAO SPECT findings in neuro-Behçet's disease. Acta Neurol Belg. 104(3):100-5, 2004
Park KS et al: Magnetic resonance imaging and proton magnetic resonance spectroscopy in neuro-Behçet's disease. Clin Exp Rheumatol. 22(5):561-7, 2004
Scully SE et al: Magnetic resonance spectroscopic findings in neuro-Behçet disease. Neurologist. 10(6):323-6, 2004
Related Anatomy
Loading...
Related Differential Diagnoses
Loading...
References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Synonyms
Neuro-Behçet disease
Definitions
Chronic, idiopathic, relapsing-remitting, multisystem vascular-inflammatory disease characterized by recurrent orogenital ulcerations and uveitis
CNS involved in up to 20-25% of patients
IMAGING
General Features
Imaging Recommendations
CT Findings
MR Findings
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Treatment
DIAGNOSTIC CHECKLIST
Consider
Selected References
Alghamdi A et al: Neuro-ophthalmological manifestations of Behçet's disease. Br J Ophthalmol. 103(1):83-7, 2019
Borhani-Haghighi A et al: Neuro-Behcet's disease: an update on diagnosis, differential diagnoses, and treatment. Mult Scler Relat Disord. 39:101906, 2019
Guedes-Barbosa LS: Oral and genital ulcers in Behçet's disease. N Engl J Med. 380(6):e7, 2019
Law LY et al: The spectrum of immune-mediated and inflammatory lesions of the brainstem: clues to diagnosis. Neurology. 93(9):390-405, 2019
Uygunoğlu U et al: Nervous system involvement in Behçet's syndrome. Curr Opin Rheumatol. 31(1):32-9, 2019
Yan D et al: The clinical features and risk factors of parenchymal neuro-Behcet's disease. J Immunol Res. 2019:7371458, 2019
Uygunoğlu U et al: Behçet's syndrome and nervous system involvement. Curr Neurol Neurosci Rep. 18(7):35, 2018
Uygunoglu U et al: Myelopathy in Behçet's disease: the bagel sign. Ann Neurol. 82(2):288-98, 2017
Alonso S et al: Pseudotumoral Behçet's disease. Reumatol Clin. 12(2):85-90, 2016
Miller JJ et al: Neuro-behçet disease and autoinflammatory disorders. Semin Neurol. 34(4):437-43, 2014
Noel N et al: Long-term outcome of neuro-Behçet's disease. Arthritis Rheumatol. 66(5):1306-14, 2014
Saip S et al: Neuro-Behçet syndrome. Handb Clin Neurol. 121:1703-23, 2014
Mora P et al: Neuro-Behçet's disease in childhood: a focus on the neuro-ophthalmological features. Orphanet J Rare Dis. 8:18, 2013
Farahangiz S et al: Magnetic resonance imaging findings and outcome of neuro-Behçet's disease: the predictive factors. Int J Rheum Dis. 15(6):e142-9, 2012
Peño IC et al: Neurobehçet disease: clinical and demographic characteristics. Eur J Neurol. 19(9):1224-7, 2012
Uluduz D et al: Clinical characteristics of pediatric-onset neuro-Behçet disease. Neurology. 77(21):1900-5, 2011
Kale N et al: The presentation of headache in neuro-Behçet's disease: a case-series. Headache. 49(3):467-70, 2009
Siva A et al: The spectrum of nervous system involvement in Behçet's syndrome and its differential diagnosis. J Neurol. 256(4):513-29, 2009
Taskapilioglu O et al: Delayed diagnosis of a neuroBehçet patient with only brainstem and cerebellar atrophy: literature review. J Neurol Sci. 277(1-2):160-3, 2009
Deprez FC et al: MRI features of Neuro-Behçet disease. JBR-BTR. 91(5):221, 2008
Heo JH et al: Neuro-Behcet's disease mimicking multiple brain tumors: diffusion-weighted MR study and literature review. J Neurol Sci. 264(1-2):177-81, 2008
Moratalla MB: Central nervous system involvement in Behçet's syndrome. J Rheumatol. 35(1):175-6, 2008
Haghighi AB et al: The pathological presentations of neuro-Behçet disease: a case report and review of the literature. Neurologist. 13(4):209-14, 2007
Joseph FG et al: Neuro-Behçet's disease in Caucasians: a study of 22 patients. Eur J Neurol. 14(2):174-80, 2007
Appenzeller S et al: Brain tumor-like lesion in Behçet disease. Rheumatol Int. 26(6):577-80, 2006
Baysal T et al: Diffusion-weighted imaging in chronic Behçet patients with and without neurological findings. Neuroradiology. 47(6):431-7, 2005
Hasegawa T et al: Neuro-Behçet's disease presenting initially as mesiotemporal lesions mimicking herpes simplex encephalitis. Eur J Neurol. 12(8):661-2, 2005
Matsuo K et al: Neuro-Behçet disease mimicking brain tumor. AJNR Am J Neuroradiol. 26(3):650-3, 2005
Cengiz N et al: Correlation of clinical, MRI and Tc-99m HMPAO SPECT findings in neuro-Behçet's disease. Acta Neurol Belg. 104(3):100-5, 2004
Park KS et al: Magnetic resonance imaging and proton magnetic resonance spectroscopy in neuro-Behçet's disease. Clin Exp Rheumatol. 22(5):561-7, 2004
Scully SE et al: Magnetic resonance spectroscopic findings in neuro-Behçet disease. Neurologist. 10(6):323-6, 2004
STATdx includes over 200,000 searchable images, including x-ray, CT, MR, and ultrasound images. To access all images, please log in or subscribe.