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Benign Breast Disease
Kelli Y. Ha, MD; Umesh D. Oza, MD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Definitions

              • Benign conditions of breast that may mimic carcinoma
                • Benign lesions with ↑ FDG uptake common
                  • Found in 1/4 of all PET/CT scans 
                • Although a sensitive imaging technique for malignant tumors, not tumor-specific
                • Underlying inflammatory processes most common cause

            IMAGING

            • General Features

              • Nuclear Medicine Findings

                DIFFERENTIAL DIAGNOSIS

                  CLINICAL ISSUES

                  • Presentation

                    DIAGNOSTIC CHECKLIST

                    • Image Interpretation Pearls

                      Selected References

                      1. Adejolu M et al: False-positive lesions mimicking breast cancer on FDG PET and PET/CT. AJR Am J Roentgenol. 198(3):W304-14, 2012
                      2. Lakhani P et al: Correlation between quantified breast densities from digital mammography and 18F-FDG PET uptake. Breast J. 15(4):339-47, 2009
                      3. Lim HS et al: FDG PET/CT for the detection and evaluation of breast diseases: usefulness and limitations. Radiographics. 27 Suppl 1:S197-213, 2007
                      4. Metser U et al: Benign nonphysiologic lesions with increased 18F-FDG uptake on PET/CT: characterization and incidence. AJR Am J Roentgenol. 189(5):1203-10, 2007
                      5. Berg WA et al: High-resolution fluorodeoxyglucose positron emission tomography with compression ("positron emission mammography") is highly accurate in depicting primary breast cancer. Breast J. 12(4):309-23, 2006
                      6. Kumar R et al: Clinicopathologic factors associated with false negative FDG-PET in primary breast cancer. Breast Cancer Res Treat. 98(3):267-74, 2006
                      7. Abouzied MM et al: 18F-FDG imaging: pitfalls and artifacts. J Nucl Med Technol. 33(3):145-55; quiz 162-3, 2005
                      8. Rosen EL et al: Detection of primary breast carcinoma with a dedicated, large-field-of-view FDG PET mammography device: initial experience. Radiology. 234(2):527-34, 2005
                      9. Hurwitz R: F-18 FDG positron emission tomographic imaging in a case of ruptured breast implant: inflammation or recurrent tumor? Clin Nucl Med. 28(9):755-6, 2003
                      10. Vranjesevic D et al: Relationship between 18F-FDG uptake and breast density in women with normal breast tissue. J Nucl Med. 44(8):1238-42, 2003
                      11. Avril N et al: Breast imaging with positron emission tomography and fluorine-18 fluorodeoxyglucose: use and limitations. J Clin Oncol. 18(20):3495-502, 2000
                      12. Bakheet SM et al: F-18 FDG uptake in breast infection and inflammation. Clin Nucl Med. 25(2):100-3, 2000
                      Related Anatomy
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                      Related Differential Diagnoses
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                      References
                      Tables

                      Tables

                      KEY FACTS

                      • Terminology

                        • Imaging

                          • Top Differential Diagnoses

                            • Clinical Issues

                              • Diagnostic Checklist

                                TERMINOLOGY

                                • Definitions

                                  • Benign conditions of breast that may mimic carcinoma
                                    • Benign lesions with ↑ FDG uptake common
                                      • Found in 1/4 of all PET/CT scans 
                                    • Although a sensitive imaging technique for malignant tumors, not tumor-specific
                                    • Underlying inflammatory processes most common cause

                                IMAGING

                                • General Features

                                  • Nuclear Medicine Findings

                                    DIFFERENTIAL DIAGNOSIS

                                      CLINICAL ISSUES

                                      • Presentation

                                        DIAGNOSTIC CHECKLIST

                                        • Image Interpretation Pearls

                                          Selected References

                                          1. Adejolu M et al: False-positive lesions mimicking breast cancer on FDG PET and PET/CT. AJR Am J Roentgenol. 198(3):W304-14, 2012
                                          2. Lakhani P et al: Correlation between quantified breast densities from digital mammography and 18F-FDG PET uptake. Breast J. 15(4):339-47, 2009
                                          3. Lim HS et al: FDG PET/CT for the detection and evaluation of breast diseases: usefulness and limitations. Radiographics. 27 Suppl 1:S197-213, 2007
                                          4. Metser U et al: Benign nonphysiologic lesions with increased 18F-FDG uptake on PET/CT: characterization and incidence. AJR Am J Roentgenol. 189(5):1203-10, 2007
                                          5. Berg WA et al: High-resolution fluorodeoxyglucose positron emission tomography with compression ("positron emission mammography") is highly accurate in depicting primary breast cancer. Breast J. 12(4):309-23, 2006
                                          6. Kumar R et al: Clinicopathologic factors associated with false negative FDG-PET in primary breast cancer. Breast Cancer Res Treat. 98(3):267-74, 2006
                                          7. Abouzied MM et al: 18F-FDG imaging: pitfalls and artifacts. J Nucl Med Technol. 33(3):145-55; quiz 162-3, 2005
                                          8. Rosen EL et al: Detection of primary breast carcinoma with a dedicated, large-field-of-view FDG PET mammography device: initial experience. Radiology. 234(2):527-34, 2005
                                          9. Hurwitz R: F-18 FDG positron emission tomographic imaging in a case of ruptured breast implant: inflammation or recurrent tumor? Clin Nucl Med. 28(9):755-6, 2003
                                          10. Vranjesevic D et al: Relationship between 18F-FDG uptake and breast density in women with normal breast tissue. J Nucl Med. 44(8):1238-42, 2003
                                          11. Avril N et al: Breast imaging with positron emission tomography and fluorine-18 fluorodeoxyglucose: use and limitations. J Clin Oncol. 18(20):3495-502, 2000
                                          12. Bakheet SM et al: F-18 FDG uptake in breast infection and inflammation. Clin Nucl Med. 25(2):100-3, 2000