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Benign Mixed Tumor of Pharyngeal Mucosal Space
Surjith Vattoth, MD, FRCR; Patricia A. Hudgins, MD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Pathology

          • Clinical Issues

            • Diagnostic Checklist

              TERMINOLOGY

              • Abbreviations

                • Benign mixed tumor (BMT) of pharyngeal mucosal space (PMS)
              • Synonyms

                • Pleomorphic adenoma (PA)
              • Definitions

                • Benign, heterogeneous tumor of minor salivary gland (MSG) origin with epithelial, myoepithelial, and stromal components

              IMAGING

              • General Features

                • CT Findings

                  • MR Findings

                    • Ultrasonographic Findings

                      • Imaging Recommendations

                        DIFFERENTIAL DIAGNOSIS

                          PATHOLOGY

                          • General Features

                            • Gross Pathologic & Surgical Features

                              • Microscopic Features

                                CLINICAL ISSUES

                                • Presentation

                                  • Demographics

                                    • Natural History & Prognosis

                                      • Treatment

                                        DIAGNOSTIC CHECKLIST

                                        • Consider

                                          • Image Interpretation Pearls

                                            Selected References

                                            1. Singh M et al: Utility of fine needle aspiration in diagnosis of intraoral minor salivary gland tumors. J Cytol. 37(1):53-7, 2020
                                            2. Li W et al: Sinonasal/nasopharyngeal pleomorphic adenoma and carcinoma ex pleomorphic adenoma: a report of 17 surgical cases combined with a literature review. Cancer Manag Res. 11:5545-55, 2019
                                            3. Zheng N et al: The diagnostic value of combining conventional, diffusion-weighted imaging and dynamic contrast-enhanced MRI for salivary gland tumors. Br J Radiol. 91(1089):20170707, 2018
                                            4. Kitamoto E et al: The application of dynamic contrast-enhanced MRI and diffusion-weighted MRI in patients with maxillofacial tumors. Acad Radiol. 22(2):210-6, 2015
                                            5. Lam PD et al: Differentiating benign and malignant salivary gland tumours: diagnostic criteria and the accuracy of dynamic contrast-enhanced MRI with high temporal resolution. Br J Radiol. 88(1049):20140685, 2015
                                            6. Zaghi S et al: MRI criteria for the diagnosis of pleomorphic adenoma: a validation study. Am J Otolaryngol. 35(6):713-8, 2014
                                            7. Espinoza S et al: Interpretation pearls for MR imaging of parotid gland tumor. Eur Ann Otorhinolaryngol Head Neck Dis. 130(1):30-5, 2013
                                            8. Oztürk E et al: CT and MRI of an unusual intranasal mass: pleomorphic adenoma. Diagn Interv Radiol. 14(4):186-8, 2008
                                            9. Hisatomi M et al: Diagnostic value of dynamic contrast-enhanced MRI in the salivary gland tumors. Oral Oncol. 43(9):940-7, 2007
                                            10. Ueda F et al: MR findings of nine cases of palatal tumor. Magn Reson Med Sci. 4(2):61-7, 2005
                                            11. Bialek EJ et al: Role of ultrasonography in diagnosis and differentiation of pleomorphic adenomas: work in progress. Arch Otolaryngol Head Neck Surg. 129(9):929-33, 2003
                                            12. Nagel H et al: Analysis of the tumour suppressor genes, FHIT and WT-1, and the tumour rejection genes, BAGE, GAGE-1/2, HAGE, MAGE-1, and MAGE-3, in benign and malignant neoplasms of the salivary glands. Mol Pathol. 56(4):226-31, 2003
                                            13. Saleh ER et al: Neural adhesion molecule (N-CAM) in pleomorphic adenoma and carcinoma ex-pleomorphic adenoma. J Oral Pathol Med. 32(9):562-7, 2003
                                            14. Jansisyanont P et al: Intraoral minor salivary gland neoplasm: a single institution experience of 80 cases. Int J Oral Maxillofac Surg. 31(3):257-61, 2002
                                            15. Jorge J et al: Juvenile intraoral pleomorphic adenoma: report of five cases and review of the literature. Int J Oral Maxillofac Surg. 31(3):273-5, 2002
                                            16. Laane CJ et al: Role of Epstein-Barr virus and cytomegalovirus in the etiology of benign parotid tumors. Head Neck. 24(5):443-50, 2002
                                            17. Sahai K et al: Fine needle aspiration cytology of minor salivary gland tumours of the palate. Cytopathology. 13(5):309-16, 2002
                                            18. Verma K et al: Role of fine needle aspiration cytology in diagnosis of pleomorphic adenomas. Cytopathology. 13(2):121-7, 2002
                                            19. Becelli R et al: Pleomorphic adenoma of the minor salivary glands of the palate. J Exp Clin Cancer Res. 20(1):25-8, 2001
                                            20. Suenaga S et al: Diagnostic value of dynamic magnetic resonance imaging for salivary gland diseases: a preliminary study. Dentomaxillofac Radiol. 30(6):314-8, 2001
                                            21. Moraitis D et al: Pleomorphic adenoma causing acute airway obstruction. J Laryngol Otol. 114(8):634-6, 2000
                                            22. Yoshihara T et al: Pleomorphic adenoma of tongue base causing dysphagia and dysphasia. J Laryngol Otol. 114(10):793-5, 2000
                                            23. Jassar P et al: Pleomorphic adenoma of the nasal septum. J Laryngol Otol. 113(5):483-5, 1999
                                            24. Lopes MA et al: A clinicopathologic study of 196 intraoral minor salivary gland tumours. J Oral Pathol Med. 28(6):264-7, 1999
                                            25. Henriksson G et al: Recurrent primary pleomorphic adenomas of salivary gland origin: intrasurgical rupture, histopathologic features, and pseudopodia. Cancer. 82(4):617-20, 1998
                                            26. Waldron CA et al: Tumors of the intraoral minor salivary glands: a demographic and histologic study of 426 cases. Oral Surg Oral Med Oral Pathol. 66(3):323-33, 1988
                                            Related Anatomy
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                                            Related Differential Diagnoses
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                                            References
                                            Tables

                                            Tables

                                            KEY FACTS

                                            • Terminology

                                              • Imaging

                                                • Top Differential Diagnoses

                                                  • Pathology

                                                    • Clinical Issues

                                                      • Diagnostic Checklist

                                                        TERMINOLOGY

                                                        • Abbreviations

                                                          • Benign mixed tumor (BMT) of pharyngeal mucosal space (PMS)
                                                        • Synonyms

                                                          • Pleomorphic adenoma (PA)
                                                        • Definitions

                                                          • Benign, heterogeneous tumor of minor salivary gland (MSG) origin with epithelial, myoepithelial, and stromal components

                                                        IMAGING

                                                        • General Features

                                                          • CT Findings

                                                            • MR Findings

                                                              • Ultrasonographic Findings

                                                                • Imaging Recommendations

                                                                  DIFFERENTIAL DIAGNOSIS

                                                                    PATHOLOGY

                                                                    • General Features

                                                                      • Gross Pathologic & Surgical Features

                                                                        • Microscopic Features

                                                                          CLINICAL ISSUES

                                                                          • Presentation

                                                                            • Demographics

                                                                              • Natural History & Prognosis

                                                                                • Treatment

                                                                                  DIAGNOSTIC CHECKLIST

                                                                                  • Consider

                                                                                    • Image Interpretation Pearls

                                                                                      Selected References

                                                                                      1. Singh M et al: Utility of fine needle aspiration in diagnosis of intraoral minor salivary gland tumors. J Cytol. 37(1):53-7, 2020
                                                                                      2. Li W et al: Sinonasal/nasopharyngeal pleomorphic adenoma and carcinoma ex pleomorphic adenoma: a report of 17 surgical cases combined with a literature review. Cancer Manag Res. 11:5545-55, 2019
                                                                                      3. Zheng N et al: The diagnostic value of combining conventional, diffusion-weighted imaging and dynamic contrast-enhanced MRI for salivary gland tumors. Br J Radiol. 91(1089):20170707, 2018
                                                                                      4. Kitamoto E et al: The application of dynamic contrast-enhanced MRI and diffusion-weighted MRI in patients with maxillofacial tumors. Acad Radiol. 22(2):210-6, 2015
                                                                                      5. Lam PD et al: Differentiating benign and malignant salivary gland tumours: diagnostic criteria and the accuracy of dynamic contrast-enhanced MRI with high temporal resolution. Br J Radiol. 88(1049):20140685, 2015
                                                                                      6. Zaghi S et al: MRI criteria for the diagnosis of pleomorphic adenoma: a validation study. Am J Otolaryngol. 35(6):713-8, 2014
                                                                                      7. Espinoza S et al: Interpretation pearls for MR imaging of parotid gland tumor. Eur Ann Otorhinolaryngol Head Neck Dis. 130(1):30-5, 2013
                                                                                      8. Oztürk E et al: CT and MRI of an unusual intranasal mass: pleomorphic adenoma. Diagn Interv Radiol. 14(4):186-8, 2008
                                                                                      9. Hisatomi M et al: Diagnostic value of dynamic contrast-enhanced MRI in the salivary gland tumors. Oral Oncol. 43(9):940-7, 2007
                                                                                      10. Ueda F et al: MR findings of nine cases of palatal tumor. Magn Reson Med Sci. 4(2):61-7, 2005
                                                                                      11. Bialek EJ et al: Role of ultrasonography in diagnosis and differentiation of pleomorphic adenomas: work in progress. Arch Otolaryngol Head Neck Surg. 129(9):929-33, 2003
                                                                                      12. Nagel H et al: Analysis of the tumour suppressor genes, FHIT and WT-1, and the tumour rejection genes, BAGE, GAGE-1/2, HAGE, MAGE-1, and MAGE-3, in benign and malignant neoplasms of the salivary glands. Mol Pathol. 56(4):226-31, 2003
                                                                                      13. Saleh ER et al: Neural adhesion molecule (N-CAM) in pleomorphic adenoma and carcinoma ex-pleomorphic adenoma. J Oral Pathol Med. 32(9):562-7, 2003
                                                                                      14. Jansisyanont P et al: Intraoral minor salivary gland neoplasm: a single institution experience of 80 cases. Int J Oral Maxillofac Surg. 31(3):257-61, 2002
                                                                                      15. Jorge J et al: Juvenile intraoral pleomorphic adenoma: report of five cases and review of the literature. Int J Oral Maxillofac Surg. 31(3):273-5, 2002
                                                                                      16. Laane CJ et al: Role of Epstein-Barr virus and cytomegalovirus in the etiology of benign parotid tumors. Head Neck. 24(5):443-50, 2002
                                                                                      17. Sahai K et al: Fine needle aspiration cytology of minor salivary gland tumours of the palate. Cytopathology. 13(5):309-16, 2002
                                                                                      18. Verma K et al: Role of fine needle aspiration cytology in diagnosis of pleomorphic adenomas. Cytopathology. 13(2):121-7, 2002
                                                                                      19. Becelli R et al: Pleomorphic adenoma of the minor salivary glands of the palate. J Exp Clin Cancer Res. 20(1):25-8, 2001
                                                                                      20. Suenaga S et al: Diagnostic value of dynamic magnetic resonance imaging for salivary gland diseases: a preliminary study. Dentomaxillofac Radiol. 30(6):314-8, 2001
                                                                                      21. Moraitis D et al: Pleomorphic adenoma causing acute airway obstruction. J Laryngol Otol. 114(8):634-6, 2000
                                                                                      22. Yoshihara T et al: Pleomorphic adenoma of tongue base causing dysphagia and dysphasia. J Laryngol Otol. 114(10):793-5, 2000
                                                                                      23. Jassar P et al: Pleomorphic adenoma of the nasal septum. J Laryngol Otol. 113(5):483-5, 1999
                                                                                      24. Lopes MA et al: A clinicopathologic study of 196 intraoral minor salivary gland tumours. J Oral Pathol Med. 28(6):264-7, 1999
                                                                                      25. Henriksson G et al: Recurrent primary pleomorphic adenomas of salivary gland origin: intrasurgical rupture, histopathologic features, and pseudopodia. Cancer. 82(4):617-20, 1998
                                                                                      26. Waldron CA et al: Tumors of the intraoral minor salivary glands: a demographic and histologic study of 426 cases. Oral Surg Oral Med Oral Pathol. 66(3):323-33, 1988