Benign mixed tumor (BMT) of pharyngeal mucosal space (PMS)
Synonyms
Pleomorphic adenoma (PA)
Definitions
Benign, heterogeneous tumor of minor salivary gland (MSG) origin with epithelial, myoepithelial, and stromal components
IMAGING
General Features
CT Findings
MR Findings
Ultrasonographic Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Singh M et al: Utility of fine needle aspiration in diagnosis of intraoral minor salivary gland tumors. J Cytol. 37(1):53-7, 2020
Li W et al: Sinonasal/nasopharyngeal pleomorphic adenoma and carcinoma ex pleomorphic adenoma: a report of 17 surgical cases combined with a literature review. Cancer Manag Res. 11:5545-55, 2019
Zheng N et al: The diagnostic value of combining conventional, diffusion-weighted imaging and dynamic contrast-enhanced MRI for salivary gland tumors. Br J Radiol. 91(1089):20170707, 2018
Kitamoto E et al: The application of dynamic contrast-enhanced MRI and diffusion-weighted MRI in patients with maxillofacial tumors. Acad Radiol. 22(2):210-6, 2015
Lam PD et al: Differentiating benign and malignant salivary gland tumours: diagnostic criteria and the accuracy of dynamic contrast-enhanced MRI with high temporal resolution. Br J Radiol. 88(1049):20140685, 2015
Zaghi S et al: MRI criteria for the diagnosis of pleomorphic adenoma: a validation study. Am J Otolaryngol. 35(6):713-8, 2014
Espinoza S et al: Interpretation pearls for MR imaging of parotid gland tumor. Eur Ann Otorhinolaryngol Head Neck Dis. 130(1):30-5, 2013
Oztürk E et al: CT and MRI of an unusual intranasal mass: pleomorphic adenoma. Diagn Interv Radiol. 14(4):186-8, 2008
Hisatomi M et al: Diagnostic value of dynamic contrast-enhanced MRI in the salivary gland tumors. Oral Oncol. 43(9):940-7, 2007
Ueda F et al: MR findings of nine cases of palatal tumor. Magn Reson Med Sci. 4(2):61-7, 2005
Bialek EJ et al: Role of ultrasonography in diagnosis and differentiation of pleomorphic adenomas: work in progress. Arch Otolaryngol Head Neck Surg. 129(9):929-33, 2003
Nagel H et al: Analysis of the tumour suppressor genes, FHIT and WT-1, and the tumour rejection genes, BAGE, GAGE-1/2, HAGE, MAGE-1, and MAGE-3, in benign and malignant neoplasms of the salivary glands. Mol Pathol. 56(4):226-31, 2003
Saleh ER et al: Neural adhesion molecule (N-CAM) in pleomorphic adenoma and carcinoma ex-pleomorphic adenoma. J Oral Pathol Med. 32(9):562-7, 2003
Jansisyanont P et al: Intraoral minor salivary gland neoplasm: a single institution experience of 80 cases. Int J Oral Maxillofac Surg. 31(3):257-61, 2002
Jorge J et al: Juvenile intraoral pleomorphic adenoma: report of five cases and review of the literature. Int J Oral Maxillofac Surg. 31(3):273-5, 2002
Laane CJ et al: Role of Epstein-Barr virus and cytomegalovirus in the etiology of benign parotid tumors. Head Neck. 24(5):443-50, 2002
Sahai K et al: Fine needle aspiration cytology of minor salivary gland tumours of the palate. Cytopathology. 13(5):309-16, 2002
Verma K et al: Role of fine needle aspiration cytology in diagnosis of pleomorphic adenomas. Cytopathology. 13(2):121-7, 2002
Becelli R et al: Pleomorphic adenoma of the minor salivary glands of the palate. J Exp Clin Cancer Res. 20(1):25-8, 2001
Suenaga S et al: Diagnostic value of dynamic magnetic resonance imaging for salivary gland diseases: a preliminary study. Dentomaxillofac Radiol. 30(6):314-8, 2001
Moraitis D et al: Pleomorphic adenoma causing acute airway obstruction. J Laryngol Otol. 114(8):634-6, 2000
Yoshihara T et al: Pleomorphic adenoma of tongue base causing dysphagia and dysphasia. J Laryngol Otol. 114(10):793-5, 2000
Jassar P et al: Pleomorphic adenoma of the nasal septum. J Laryngol Otol. 113(5):483-5, 1999
Lopes MA et al: A clinicopathologic study of 196 intraoral minor salivary gland tumours. J Oral Pathol Med. 28(6):264-7, 1999
Henriksson G et al: Recurrent primary pleomorphic adenomas of salivary gland origin: intrasurgical rupture, histopathologic features, and pseudopodia. Cancer. 82(4):617-20, 1998
Waldron CA et al: Tumors of the intraoral minor salivary glands: a demographic and histologic study of 426 cases. Oral Surg Oral Med Oral Pathol. 66(3):323-33, 1988
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
Diagnostic Checklist
TERMINOLOGY
Abbreviations
Benign mixed tumor (BMT) of pharyngeal mucosal space (PMS)
Synonyms
Pleomorphic adenoma (PA)
Definitions
Benign, heterogeneous tumor of minor salivary gland (MSG) origin with epithelial, myoepithelial, and stromal components
IMAGING
General Features
CT Findings
MR Findings
Ultrasonographic Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Gross Pathologic & Surgical Features
Microscopic Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
Singh M et al: Utility of fine needle aspiration in diagnosis of intraoral minor salivary gland tumors. J Cytol. 37(1):53-7, 2020
Li W et al: Sinonasal/nasopharyngeal pleomorphic adenoma and carcinoma ex pleomorphic adenoma: a report of 17 surgical cases combined with a literature review. Cancer Manag Res. 11:5545-55, 2019
Zheng N et al: The diagnostic value of combining conventional, diffusion-weighted imaging and dynamic contrast-enhanced MRI for salivary gland tumors. Br J Radiol. 91(1089):20170707, 2018
Kitamoto E et al: The application of dynamic contrast-enhanced MRI and diffusion-weighted MRI in patients with maxillofacial tumors. Acad Radiol. 22(2):210-6, 2015
Lam PD et al: Differentiating benign and malignant salivary gland tumours: diagnostic criteria and the accuracy of dynamic contrast-enhanced MRI with high temporal resolution. Br J Radiol. 88(1049):20140685, 2015
Zaghi S et al: MRI criteria for the diagnosis of pleomorphic adenoma: a validation study. Am J Otolaryngol. 35(6):713-8, 2014
Espinoza S et al: Interpretation pearls for MR imaging of parotid gland tumor. Eur Ann Otorhinolaryngol Head Neck Dis. 130(1):30-5, 2013
Oztürk E et al: CT and MRI of an unusual intranasal mass: pleomorphic adenoma. Diagn Interv Radiol. 14(4):186-8, 2008
Hisatomi M et al: Diagnostic value of dynamic contrast-enhanced MRI in the salivary gland tumors. Oral Oncol. 43(9):940-7, 2007
Ueda F et al: MR findings of nine cases of palatal tumor. Magn Reson Med Sci. 4(2):61-7, 2005
Bialek EJ et al: Role of ultrasonography in diagnosis and differentiation of pleomorphic adenomas: work in progress. Arch Otolaryngol Head Neck Surg. 129(9):929-33, 2003
Nagel H et al: Analysis of the tumour suppressor genes, FHIT and WT-1, and the tumour rejection genes, BAGE, GAGE-1/2, HAGE, MAGE-1, and MAGE-3, in benign and malignant neoplasms of the salivary glands. Mol Pathol. 56(4):226-31, 2003
Saleh ER et al: Neural adhesion molecule (N-CAM) in pleomorphic adenoma and carcinoma ex-pleomorphic adenoma. J Oral Pathol Med. 32(9):562-7, 2003
Jansisyanont P et al: Intraoral minor salivary gland neoplasm: a single institution experience of 80 cases. Int J Oral Maxillofac Surg. 31(3):257-61, 2002
Jorge J et al: Juvenile intraoral pleomorphic adenoma: report of five cases and review of the literature. Int J Oral Maxillofac Surg. 31(3):273-5, 2002
Laane CJ et al: Role of Epstein-Barr virus and cytomegalovirus in the etiology of benign parotid tumors. Head Neck. 24(5):443-50, 2002
Sahai K et al: Fine needle aspiration cytology of minor salivary gland tumours of the palate. Cytopathology. 13(5):309-16, 2002
Verma K et al: Role of fine needle aspiration cytology in diagnosis of pleomorphic adenomas. Cytopathology. 13(2):121-7, 2002
Becelli R et al: Pleomorphic adenoma of the minor salivary glands of the palate. J Exp Clin Cancer Res. 20(1):25-8, 2001
Suenaga S et al: Diagnostic value of dynamic magnetic resonance imaging for salivary gland diseases: a preliminary study. Dentomaxillofac Radiol. 30(6):314-8, 2001
Moraitis D et al: Pleomorphic adenoma causing acute airway obstruction. J Laryngol Otol. 114(8):634-6, 2000
Yoshihara T et al: Pleomorphic adenoma of tongue base causing dysphagia and dysphasia. J Laryngol Otol. 114(10):793-5, 2000
Jassar P et al: Pleomorphic adenoma of the nasal septum. J Laryngol Otol. 113(5):483-5, 1999
Lopes MA et al: A clinicopathologic study of 196 intraoral minor salivary gland tumours. J Oral Pathol Med. 28(6):264-7, 1999
Henriksson G et al: Recurrent primary pleomorphic adenomas of salivary gland origin: intrasurgical rupture, histopathologic features, and pseudopodia. Cancer. 82(4):617-20, 1998
Waldron CA et al: Tumors of the intraoral minor salivary glands: a demographic and histologic study of 426 cases. Oral Surg Oral Med Oral Pathol. 66(3):323-33, 1988
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