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Benign Mixed Tumor of Pharyngeal Mucosal Space
Patricia A. Hudgins, MD, FACR
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Clinical Issues

          • Diagnostic Checklist

            TERMINOLOGY

            • Abbreviations

              • Benign mixed tumor (BMT) of minor salivary gland (MSG)
              • Pleomorphic adenoma of oral mucosal (OMS) or pharyngeal mucosal space (PMS)
            • Synonyms

              • Pleomorphic adenoma (PA)
            • Definitions

              • Benign, heterogeneous tumor of MSG origin with epithelial, myoepithelial, and stromal components

            IMAGING

            • General Features

              • CT Findings

                • MR Findings

                  • Ultrasonographic Findings

                    • Imaging Recommendations

                      DIFFERENTIAL DIAGNOSIS

                        PATHOLOGY

                        • General Features

                          • Gross Pathologic & Surgical Features

                            • Microscopic Features

                              CLINICAL ISSUES

                              • Presentation

                                • Demographics

                                  • Natural History & Prognosis

                                    • Treatment

                                      DIAGNOSTIC CHECKLIST

                                      • Consider

                                        • Image Interpretation Pearls

                                          Selected References

                                          1. Kitamoto E et al: The application of dynamic contrast-enhanced MRI and diffusion-weighted MRI in patients with maxillofacial tumors. Acad Radiol. 22(2):210-6, 2015
                                          2. Zaghi S et al: MRI criteria for the diagnosis of pleomorphic adenoma: a validation study. Am J Otolaryngol. 35(6):713-8, 2014
                                          3. Espinoza S et al: Interpretation pearls for MR imaging of parotid gland tumor. Eur Ann Otorhinolaryngol Head Neck Dis. 130(1):30-5, 2013
                                          4. Oztürk E et al: CT and MRI of an unusual intranasal mass: pleomorphic adenoma. Diagn Interv Radiol. 14(4):186-8, 2008
                                          5. Hisatomi M et al: Diagnostic value of dynamic contrast-enhanced MRI in the salivary gland tumors. Oral Oncol. 43(9):940-7, 2007
                                          6. Ueda F et al: MR findings of nine cases of palatal tumor. Magn Reson Med Sci. 4(2):61-7, 2005
                                          7. Bialek EJ et al: Role of ultrasonography in diagnosis and differentiation of pleomorphic adenomas: work in progress. Arch Otolaryngol Head Neck Surg. 129(9):929-33, 2003
                                          8. Nagel H et al: Analysis of the tumour suppressor genes, FHIT and WT-1, and the tumour rejection genes, BAGE, GAGE-1/2, HAGE, MAGE-1, and MAGE-3, in benign and malignant neoplasms of the salivary glands. Mol Pathol. 56(4):226-31, 2003
                                          9. Saleh ER et al: Neural adhesion molecule (N-CAM) in pleomorphic adenoma and carcinoma ex-pleomorphic adenoma. J Oral Pathol Med. 32(9):562-7, 2003
                                          10. Jansisyanont P et al: Intraoral minor salivary gland neoplasm: a single institution experience of 80 cases. Int J Oral Maxillofac Surg. 31(3):257-61, 2002
                                          11. Jorge J et al: Juvenile intraoral pleomorphic adenoma: report of five cases and review of the literature. Int J Oral Maxillofac Surg. 31(3):273-5, 2002
                                          12. Laane CJ et al: Role of Epstein-Barr virus and cytomegalovirus in the etiology of benign parotid tumors. Head Neck. 24(5):443-50, 2002
                                          13. Sahai K et al: Fine needle aspiration cytology of minor salivary gland tumours of the palate. Cytopathology. 13(5):309-16, 2002
                                          14. Verma K et al: Role of fine needle aspiration cytology in diagnosis of pleomorphic adenomas. Cytopathology. 13(2):121-7, 2002
                                          15. Becelli R et al: Pleomorphic adenoma of the minor salivary glands of the palate. J Exp Clin Cancer Res. 20(1):25-8, 2001
                                          16. Suenaga S et al: Diagnostic value of dynamic magnetic resonance imaging for salivary gland diseases: a preliminary study. Dentomaxillofac Radiol. 30(6):314-8, 2001
                                          17. Moraitis D et al: Pleomorphic adenoma causing acute airway obstruction. J Laryngol Otol. 114(8):634-6, 2000
                                          18. Yoshihara T et al: Pleomorphic adenoma of tongue base causing dysphagia and dysphasia. J Laryngol Otol. 114(10):793-5, 2000
                                          19. Jassar P et al: Pleomorphic adenoma of the nasal septum. J Laryngol Otol. 113(5):483-5, 1999
                                          20. Lopes MA et al: A clinicopathologic study of 196 intraoral minor salivary gland tumours. J Oral Pathol Med. 28(6):264-7, 1999
                                          21. Henriksson G et al: Recurrent primary pleomorphic adenomas of salivary gland origin: intrasurgical rupture, histopathologic features, and pseudopodia. Cancer. 82(4):617-20, 1998
                                          22. Waldron CA et al: Tumors of the intraoral minor salivary glands: a demographic and histologic study of 426 cases. Oral Surg Oral Med Oral Pathol. 66(3):323-33, 1988
                                          Related Anatomy
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                                          Related Differential Diagnoses
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                                          References
                                          Tables

                                          Tables

                                          KEY FACTS

                                          • Terminology

                                            • Imaging

                                              • Top Differential Diagnoses

                                                • Clinical Issues

                                                  • Diagnostic Checklist

                                                    TERMINOLOGY

                                                    • Abbreviations

                                                      • Benign mixed tumor (BMT) of minor salivary gland (MSG)
                                                      • Pleomorphic adenoma of oral mucosal (OMS) or pharyngeal mucosal space (PMS)
                                                    • Synonyms

                                                      • Pleomorphic adenoma (PA)
                                                    • Definitions

                                                      • Benign, heterogeneous tumor of MSG origin with epithelial, myoepithelial, and stromal components

                                                    IMAGING

                                                    • General Features

                                                      • CT Findings

                                                        • MR Findings

                                                          • Ultrasonographic Findings

                                                            • Imaging Recommendations

                                                              DIFFERENTIAL DIAGNOSIS

                                                                PATHOLOGY

                                                                • General Features

                                                                  • Gross Pathologic & Surgical Features

                                                                    • Microscopic Features

                                                                      CLINICAL ISSUES

                                                                      • Presentation

                                                                        • Demographics

                                                                          • Natural History & Prognosis

                                                                            • Treatment

                                                                              DIAGNOSTIC CHECKLIST

                                                                              • Consider

                                                                                • Image Interpretation Pearls

                                                                                  Selected References

                                                                                  1. Kitamoto E et al: The application of dynamic contrast-enhanced MRI and diffusion-weighted MRI in patients with maxillofacial tumors. Acad Radiol. 22(2):210-6, 2015
                                                                                  2. Zaghi S et al: MRI criteria for the diagnosis of pleomorphic adenoma: a validation study. Am J Otolaryngol. 35(6):713-8, 2014
                                                                                  3. Espinoza S et al: Interpretation pearls for MR imaging of parotid gland tumor. Eur Ann Otorhinolaryngol Head Neck Dis. 130(1):30-5, 2013
                                                                                  4. Oztürk E et al: CT and MRI of an unusual intranasal mass: pleomorphic adenoma. Diagn Interv Radiol. 14(4):186-8, 2008
                                                                                  5. Hisatomi M et al: Diagnostic value of dynamic contrast-enhanced MRI in the salivary gland tumors. Oral Oncol. 43(9):940-7, 2007
                                                                                  6. Ueda F et al: MR findings of nine cases of palatal tumor. Magn Reson Med Sci. 4(2):61-7, 2005
                                                                                  7. Bialek EJ et al: Role of ultrasonography in diagnosis and differentiation of pleomorphic adenomas: work in progress. Arch Otolaryngol Head Neck Surg. 129(9):929-33, 2003
                                                                                  8. Nagel H et al: Analysis of the tumour suppressor genes, FHIT and WT-1, and the tumour rejection genes, BAGE, GAGE-1/2, HAGE, MAGE-1, and MAGE-3, in benign and malignant neoplasms of the salivary glands. Mol Pathol. 56(4):226-31, 2003
                                                                                  9. Saleh ER et al: Neural adhesion molecule (N-CAM) in pleomorphic adenoma and carcinoma ex-pleomorphic adenoma. J Oral Pathol Med. 32(9):562-7, 2003
                                                                                  10. Jansisyanont P et al: Intraoral minor salivary gland neoplasm: a single institution experience of 80 cases. Int J Oral Maxillofac Surg. 31(3):257-61, 2002
                                                                                  11. Jorge J et al: Juvenile intraoral pleomorphic adenoma: report of five cases and review of the literature. Int J Oral Maxillofac Surg. 31(3):273-5, 2002
                                                                                  12. Laane CJ et al: Role of Epstein-Barr virus and cytomegalovirus in the etiology of benign parotid tumors. Head Neck. 24(5):443-50, 2002
                                                                                  13. Sahai K et al: Fine needle aspiration cytology of minor salivary gland tumours of the palate. Cytopathology. 13(5):309-16, 2002
                                                                                  14. Verma K et al: Role of fine needle aspiration cytology in diagnosis of pleomorphic adenomas. Cytopathology. 13(2):121-7, 2002
                                                                                  15. Becelli R et al: Pleomorphic adenoma of the minor salivary glands of the palate. J Exp Clin Cancer Res. 20(1):25-8, 2001
                                                                                  16. Suenaga S et al: Diagnostic value of dynamic magnetic resonance imaging for salivary gland diseases: a preliminary study. Dentomaxillofac Radiol. 30(6):314-8, 2001
                                                                                  17. Moraitis D et al: Pleomorphic adenoma causing acute airway obstruction. J Laryngol Otol. 114(8):634-6, 2000
                                                                                  18. Yoshihara T et al: Pleomorphic adenoma of tongue base causing dysphagia and dysphasia. J Laryngol Otol. 114(10):793-5, 2000
                                                                                  19. Jassar P et al: Pleomorphic adenoma of the nasal septum. J Laryngol Otol. 113(5):483-5, 1999
                                                                                  20. Lopes MA et al: A clinicopathologic study of 196 intraoral minor salivary gland tumours. J Oral Pathol Med. 28(6):264-7, 1999
                                                                                  21. Henriksson G et al: Recurrent primary pleomorphic adenomas of salivary gland origin: intrasurgical rupture, histopathologic features, and pseudopodia. Cancer. 82(4):617-20, 1998
                                                                                  22. Waldron CA et al: Tumors of the intraoral minor salivary glands: a demographic and histologic study of 426 cases. Oral Surg Oral Med Oral Pathol. 66(3):323-33, 1988