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KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
- Acute beryllium exposure (ABE)
- Chronic beryllium disease (CBD)
- Delayed-type hypersensitivity to beryllium (BES)
Synonyms
- Salem sarcoidosis
- Seen in young women in the fluorescent light industry in Salem, Massachusetts in 1940s
- Salem sarcoidosis
Definitions
- Beryllium: Gray, lightweight metal with high thermal stability and conductivity
- Aerospace, telecommunication, defense, computer, medical, glass blowing, and nuclear industries
- Inhalation of dust, aerosol, or fumes produces 2 types of lung injury
- Acute chemical pneumonitis (uncommon)
- Chronic granulomatous disease
- Diagnosis requires
- History of beryllium exposure
- Positive beryllium-specific lymphocyte proliferation test (in blood or bronchoalveolar lavage fluid)
- Nonnecrotizing granulomas on histology
- Beryllium: Gray, lightweight metal with high thermal stability and conductivity
IMAGING
General Features
Radiographic Findings
CT Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Sizar O et al: Berylliosis 2021
- MacMurdo MG et al: Chronic beryllium disease: update on a moving target. Chest. 158(6):2458-66, 2020
- Martínez González C et al: Berylliosis: a granulomatosis to remind us of the importance of occupational history. Arch Bronconeumol. 56(7):470-1, 2020
- Ohshimo S et al: Differential diagnosis of granulomatous lung disease: clues and pitfalls: number 4 in the series "Pathology for the clinician" edited by Peter Dorfmüller and Alberto Cavazza. Eur Respir Rev. 26(145), 2017
- Mayer A et al: Beryllium and other metal-induced lung disease. Curr Opin Pulm Med. 21(2):178-84, 2015
- Halldin CN et al: Validation of the international labour office digitized standard images for recognition and classification of radiographs of pneumoconiosis. Acad Radiol. 21(3):305-11, 2014
- Mayer AS et al: Sarcoidosis and chronic beryllium disease: similarities and differences. Semin Respir Crit Care Med. 35(3):316-29, 2014
- Flors L et al: Uncommon occupational lung diseases: high-resolution CT findings. AJR Am J Roentgenol. 194(1):W20-6, 2010
- Sharma N et al: Chronic beryllium disease: computed tomographic findings. J Comput Assist Tomogr. 34(6):945-8, 2010
Related Anatomy
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Related Differential Diagnoses
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References
Tables
Tables
KEY FACTS
Terminology
Imaging
Top Differential Diagnoses
Pathology
Clinical Issues
TERMINOLOGY
Abbreviations
- Acute beryllium exposure (ABE)
- Chronic beryllium disease (CBD)
- Delayed-type hypersensitivity to beryllium (BES)
Synonyms
- Salem sarcoidosis
- Seen in young women in the fluorescent light industry in Salem, Massachusetts in 1940s
- Salem sarcoidosis
Definitions
- Beryllium: Gray, lightweight metal with high thermal stability and conductivity
- Aerospace, telecommunication, defense, computer, medical, glass blowing, and nuclear industries
- Inhalation of dust, aerosol, or fumes produces 2 types of lung injury
- Acute chemical pneumonitis (uncommon)
- Chronic granulomatous disease
- Diagnosis requires
- History of beryllium exposure
- Positive beryllium-specific lymphocyte proliferation test (in blood or bronchoalveolar lavage fluid)
- Nonnecrotizing granulomas on histology
- Beryllium: Gray, lightweight metal with high thermal stability and conductivity
IMAGING
General Features
Radiographic Findings
CT Findings
Imaging Recommendations
DIFFERENTIAL DIAGNOSIS
PATHOLOGY
General Features
Staging, Grading, & Classification
Gross Pathologic & Surgical Features
CLINICAL ISSUES
Presentation
Demographics
Natural History & Prognosis
Treatment
DIAGNOSTIC CHECKLIST
Consider
Image Interpretation Pearls
Selected References
- Sizar O et al: Berylliosis 2021
- MacMurdo MG et al: Chronic beryllium disease: update on a moving target. Chest. 158(6):2458-66, 2020
- Martínez González C et al: Berylliosis: a granulomatosis to remind us of the importance of occupational history. Arch Bronconeumol. 56(7):470-1, 2020
- Ohshimo S et al: Differential diagnosis of granulomatous lung disease: clues and pitfalls: number 4 in the series "Pathology for the clinician" edited by Peter Dorfmüller and Alberto Cavazza. Eur Respir Rev. 26(145), 2017
- Mayer A et al: Beryllium and other metal-induced lung disease. Curr Opin Pulm Med. 21(2):178-84, 2015
- Halldin CN et al: Validation of the international labour office digitized standard images for recognition and classification of radiographs of pneumoconiosis. Acad Radiol. 21(3):305-11, 2014
- Mayer AS et al: Sarcoidosis and chronic beryllium disease: similarities and differences. Semin Respir Crit Care Med. 35(3):316-29, 2014
- Flors L et al: Uncommon occupational lung diseases: high-resolution CT findings. AJR Am J Roentgenol. 194(1):W20-6, 2010
- Sharma N et al: Chronic beryllium disease: computed tomographic findings. J Comput Assist Tomogr. 34(6):945-8, 2010
