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Biliary Atresia
Shane C. Masters, MD, PhD
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KEY FACTS

  • Terminology

    • Imaging

      • Top Differential Diagnoses

        • Diagnostic Checklist

          TERMINOLOGY

          • Definitions

            • Obliterative cholangiopathy of neonates involving intrahepatic and extrahepatic ducts to varying degrees
              • Resulting cholestasis leads to cirrhosis and death if untreated

          IMAGING

          • Nuclear Medicine Findings

            • Imaging Recommendations

              • Artifacts and Quality Control

                • Ultrasonographic Findings

                  • Other Modality Findings

                    DIFFERENTIAL DIAGNOSIS

                      PATHOLOGY

                      • General Features

                        • Staging, Grading, & Classification

                          CLINICAL ISSUES

                          • Presentation

                            • Natural History & Prognosis

                              • Treatment

                                DIAGNOSTIC CHECKLIST

                                • Consider

                                  • Image Interpretation Pearls

                                    Selected References

                                    1. Moreira RK et al: Biliary atresia: a multidisciplinary approach to diagnosis and management. Arch Pathol Lab Med. 136(7):746-60, 2012
                                    2. Tulchinsky M et al: SNM practice guideline for hepatobiliary scintigraphy 4.0. J Nucl Med Technol. 2010 Dec;38(4):210-8. Epub 2010 Nov 15. Erratum in: J Nucl Med Technol. 40(3):17A, 2012
                                    3. De Bruyne R et al: Clinical practice: neonatal cholestasis. Eur J Pediatr. 170(3):279-84, 2011
                                    4. Mittal V et al: Role of abdominal sonography in the preoperative diagnosis of extrahepatic biliary atresia in infants younger than 90 days. AJR Am J Roentgenol. 196(4):W438-45, 2011
                                    5. Rozel C et al: Imaging of biliary disorders in children. Pediatr Radiol. 41(2):208-20, 2011
                                    6. Hartley JL et al: Biliary atresia. Lancet. 374(9702):1704-13, 2009
                                    7. Serinet MO et al: Impact of age at Kasai operation on its results in late childhood and adolescence: a rational basis for biliary atresia screening. Pediatrics. 123(5):1280-6, 2009
                                    8. Poddar U et al: Ursodeoxycholic acid-augmented hepatobiliary scintigraphy in the evaluation of neonatal jaundice. J Nucl Med. 45(9):1488-92, 2004
                                    9. Balich S et al: Alagille's syndrome. New manifestations. Clin Nucl Med. 21(2):98-101, 1996
                                    Related Anatomy
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                                    Related Differential Diagnoses
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                                    References
                                    Tables

                                    Tables

                                    KEY FACTS

                                    • Terminology

                                      • Imaging

                                        • Top Differential Diagnoses

                                          • Diagnostic Checklist

                                            TERMINOLOGY

                                            • Definitions

                                              • Obliterative cholangiopathy of neonates involving intrahepatic and extrahepatic ducts to varying degrees
                                                • Resulting cholestasis leads to cirrhosis and death if untreated

                                            IMAGING

                                            • Nuclear Medicine Findings

                                              • Imaging Recommendations

                                                • Artifacts and Quality Control

                                                  • Ultrasonographic Findings

                                                    • Other Modality Findings

                                                      DIFFERENTIAL DIAGNOSIS

                                                        PATHOLOGY

                                                        • General Features

                                                          • Staging, Grading, & Classification

                                                            CLINICAL ISSUES

                                                            • Presentation

                                                              • Natural History & Prognosis

                                                                • Treatment

                                                                  DIAGNOSTIC CHECKLIST

                                                                  • Consider

                                                                    • Image Interpretation Pearls

                                                                      Selected References

                                                                      1. Moreira RK et al: Biliary atresia: a multidisciplinary approach to diagnosis and management. Arch Pathol Lab Med. 136(7):746-60, 2012
                                                                      2. Tulchinsky M et al: SNM practice guideline for hepatobiliary scintigraphy 4.0. J Nucl Med Technol. 2010 Dec;38(4):210-8. Epub 2010 Nov 15. Erratum in: J Nucl Med Technol. 40(3):17A, 2012
                                                                      3. De Bruyne R et al: Clinical practice: neonatal cholestasis. Eur J Pediatr. 170(3):279-84, 2011
                                                                      4. Mittal V et al: Role of abdominal sonography in the preoperative diagnosis of extrahepatic biliary atresia in infants younger than 90 days. AJR Am J Roentgenol. 196(4):W438-45, 2011
                                                                      5. Rozel C et al: Imaging of biliary disorders in children. Pediatr Radiol. 41(2):208-20, 2011
                                                                      6. Hartley JL et al: Biliary atresia. Lancet. 374(9702):1704-13, 2009
                                                                      7. Serinet MO et al: Impact of age at Kasai operation on its results in late childhood and adolescence: a rational basis for biliary atresia screening. Pediatrics. 123(5):1280-6, 2009
                                                                      8. Poddar U et al: Ursodeoxycholic acid-augmented hepatobiliary scintigraphy in the evaluation of neonatal jaundice. J Nucl Med. 45(9):1488-92, 2004
                                                                      9. Balich S et al: Alagille's syndrome. New manifestations. Clin Nucl Med. 21(2):98-101, 1996